Sentences with phrase «cell receptors from»

Many researchers have explored ways to eliminate cell receptors from recognizing the constant region of dengue antibodies; however, traditional immunization techniques are generally incapable of creating antibodies that can not bind to these receptors.

Not exact matches

Receptor sites in the walls of the milk - producing cells of the alveoli stretch and prevent prolactin from entering to stimulate more breast milk production.

To confirm that breast milk's protective properties were due to EGF, the researchers gave premature baby mice a drug that selectively turned off their cell receptors to EGF — a technique that prevents EGF from entering the gut cells.

Some tumor cells use this receptor to hide from the immune system (SN: 4/1/17, p. 24).

The protein expressed by the gene is thought to bind to serotonin receptor molecules and ferry them to the cell surface, positioning them to receive serotonin's signals from neighboring cells.

But H5N1, well adapted to the higher temperatures and particular cell receptors found in chickens, does not spread from person to person.

By hindering LMPTP, the drug reawakens insulin receptors on the surface of cells — especially in the liver — which normally absorb excess sugar from the blood when they detect insulin.

One way cancer cells do this is by expressing a protein ligand that binds to a receptor on the T cells to prevent the T cell from recognizing and attacking the cancer cell.

The immune system depends on molecules called T cell receptors on the surface of T cells to recognize and respond to foreign antigens from virus - infected cells, tumors and other threats.

We show that vascular smooth muscle cells and blood vessels from estrogen receptor β (ERβ)-- deficient mice exhibit multiple functional abnormalities.

«Myeloid - derived suppressor cells (MDSCs) produce reactive nitrogen radicals that alter the receptors on the surface of the tumour to hide it from cytotoxic lymphocytes that kill tumour cells.

If we can remove sialic acid residues from the cell surface, this will force the insulin receptor do its job of absorbing blood sugar properly.

To do their job, T cells use specialized receptors to differentiate healthy cells from cancer cells.

The serotonin is then released from the receptor and pumped back to the original cell.

The two postembryonic touch receptor neurons in the nematode Caenorhabditis elegans arise from essentially identical cell lineages and have the same ultrastructural features.

This drug (vedolizumab) blocks a specific adhesion molecule on the surface of the T - cell and thereby inhibits immune cells from binding themselves to receptors present in the intestine, preventing the T - cells from penetrating the blood vessels in the intestinal tissue.

Now that researchers know from their cell studies that this family of receptors can essentially flip its own switch, they can use that information to design drugs to prevent that from happening when it shouldn't.

Thus, signals coming from a given neuron provide information about odors that activate the specific receptor protein expressed by that cell.

Physicist Marshall Stoneham and his colleagues at University College London report they have constructed a specific mechanism based on the properties of so - called G - protein coupled receptors, which project from olfactory cells inside the nose.

Equipped with this receptor, the cancer cells are able to recognise and migrate towards a gradient of a substance that is secreted from the lymphatic vessels and binds to the receptor.

The current paper shows that treating with retinoids simultaneously with anti-estrogen therapies may pull cofactors for progesterone receptors away from their posts, disallowing their ability to open DNA at the point of CK5 and keeping the growth of dangerous CK5 + cells in check.

A special receptor on cells that line the sinuses, throat and lungs evolved to protect mammals from developing a range of allergies and asthma, according to a study from researchers at Johns Hopkins Bloomberg School of Public Health.

Now, scientists from the Perelman School of Medicine at the University of Pennsylvania reveal that the release of AMPs is partially controlled by bitter taste receptors in the upper airway on a cell previously identified in animals and only recently in humans known as solitary chemosensory cells (SCCs).

The scientists harvested the mutant hemagglutanin proteins from the cells and tested how strongly they bound to human - type and bird - type receptors.

The drug blocks CTLA - 4, a protein receptor on the surface of T - cells that serves as a molecular stop sign, preventing the immune system from going into overdrive.

Dr. Jochen Maurer and his research group were able to cultivate several cancer stem cell lines from triple receptor - negative breast cancer that are excellent representations of the original tumors they isolated from the patients.

Patricia McGowan of University College Dublin, Ireland, treated triple - negative cells taken from seven patients with a compound that inhibits receptors important for the cell division and spread of this form of cancer.

In a final experiment, the group gave the animals a compound that prevented LPA from binding to its receptor on mouse brain cells, right before they were injected with hydrocephalus - inducing LPA.

Zwiebel and colleagues scanned the mosquito genome looking for genes similar to those that generate fruit fly odorant receptors, proteins that project from nerve cells and initiate a biochemical cascade when they encounter certain molecules in the air.

Scientists have previously identified a number of mouse smell receptors, cell - surface proteins in the animals» noses that pick up everything from the fragrance of food to the scent of fear (ScienceNOW, 21 August 2008).

Studying these receptor molecules in detail is extremely difficult, because they almost always stop working if removed from the cell membrane.

Pfizer's Selzentry (generic name, maraviroc), which went on sale in the United States in September, binds with host cell receptors to prevent the virus from attaching to and entering healthy host cells.

This group of about 800 receptors plays a central role in transferring signals from the environment into the cell and is of great interest for drug development.

«Inflammatory arthritis is caused when immune cells are recruited from the blood into the joint in a highly regulated process controlled by chemoattractants and adhesion receptors,» says Andrew Luster, MD, PhD, chief of the MGH Division of Rheumatology, Allergy and Immunology, director of the CIID and senior author of the report.

The key discovery made by the CSHL team is that FER is able to activate a receptor on the surface of ovarian cells «from below,» as it were — by interacting with a portion of the receptor that penetrates the cell membrane and plunges into the cytoplasm.

When a methyl group is attached to a gene, it keeps that gene hidden from cells» protein - building machinery — in this case, preventing the cells from manufacturing GABA - A receptors.

Functional glutamate receptor (GluRs) were transiently expressed in cultured mammalian cells from cloned complementary DNAs encoding GluR - A, - B, - C, or - D polypeptides.

«In the future, it should be possible to block these areas in the toxin and receptor in order to prevent the toxin from entering the host cell,» Papatheodorou explained.

But dolphins, fish, and platypuses each evolved the receptor cells independently, from different organs unique to each lineage.

When chemical phosphate groups are added to the receptors, they move from the cytoplasm and cluster on the edges of nerve cells along synapses — the spaces between nerve cells where messages transmit from one cell to another.

In laboratory studies reported in the Proceedings of the National Academy of Sciences (PNAS), the researchers found that these «neutralizing» antibodies prevented a key part of the virus, known as MERS CoV, from attaching to protein receptors that allow the virus to infect human cells.

For the CRISPR trial, a UPenn - led team wants to remove T cells from patients and use a harmless virus to give the cells a receptor for NY - ESO - 1, a protein that is often present on certain tumors but not on most healthy cells.

In the latter group, a neutralizing antibody blocked TNF and prevented it from binding to a receptor on the premalignant liver cells; loss of the receptor prevented the TNF from triggering a molecular cascade that turns on the NF - kB master switch.

And when the researchers from Ruhr - University Bochum in Germany activated these receptors, they found that they regulated the way in which the airways smooth muscle cells contracted.

Epidermal growth factor receptor (EGFR) mutations found in the circulating free tumor DNA (ctDNA) from the plasma of advanced non-small cell lung cancer (NSCLC) patients correlates well with the EGFR mutations from patient - matched tumor tissue DNA.

Now, findings from Monell reveal that a person's sensitivity to bitter taste is shaped not only by which taste genes that person has, but also by how much messenger RNA — the gene's instruction guide that tells a taste cell to build a specific receptor — their cells make.

Here, Patil et al. have carried out single RNA - seq and sequenced the T cell receptors (TCRs) of CD4 + T cells from human blood to identify precursors that give rise to CD4 - CTLs.

Checkpoint inhibitors like ipilimumab — which has been on the market since 2011 — nivolumab, and pembrolizumab stop tumor cells from stimulating the receptors.

«Activation of these cell receptors appear to prevent brain cells from cleaning out the trash — the toxic buildup of proteins, such as alpha - synuclein, tau and amyloid, common in neurodegenerative diseases,» says the study's senior author, neurologist Charbel Moussa, MBBS, PhD, director of Georgetown's Laboratory for Dementia and Parkinsonism, and scientific and clinical research director of the GUMC Translational Neurotherapeutics Program.

The gene, Igf2r, directs the body's cells to produce IGF - 2 receptors that stick to the protein and prevent it from circulating and promoting growth.