Sentences with phrase «cell recognition of»

By contrast, NK cell profiles of individuals receiving an HIV vaccine indicated NK cell engagement through direct cell recognition of target cells.

Central to the concept of immunoediting is the idea that T - cell recognition of tumor - specific antigens drives the destruction of early tumors, and later the antigenic «sculpting» of persistent tumor cells.

Not exact matches

«From the stuff of the stars to the stuff of ourselves, From gyrating electrons to the genes in our cells, The truth is a beauty and should gain recognition, It's more mind than machine, less cog than cognition.»

The discovery, reported in June in Cell, completely breaks with the standard model of facial recognition, which claims each face you recognize is represented by a single neuron (one cell firing when you see your grandmother, another when you see Jennifer AnistCell, completely breaks with the standard model of facial recognition, which claims each face you recognize is represented by a single neuron (one cell firing when you see your grandmother, another when you see Jennifer Anistcell firing when you see your grandmother, another when you see Jennifer Aniston).

In 2004, he joined a Marie Curie Research Training Network of the European Commission, studying the sugar - protein interactions that mediate cell - cell recognition.

The tools included TCRdist, which researchers used to calculate the similarity and differences of key features of T cell receptors, such as amino acid sequences in important regions for antigen recognition.

Renowned for his extensive work in molecular genetics, Brenner is best known locally for his role in bringing leading - edge biomedical sciences research to Singapore and in spearheading the Fugu genome project, which brought the Institute of Molecular and Cell Biology international recognition.

Wapner's narrative follows developments from the recognition of a chromosomal abnormality in cancer cells to the production of a targeted drug against what had been a lethal leukemia.

Antigens are exposed on the surface of DCs in a protein complex along with major histocompatibility complex (MHC) proteins that mediate the recognition and activation of the appropriate T cell subtype.

One possibility is that nonoxyl - 9 samples may damage cells beyond recognition, so live cells falsely appear to make up a larger proportion of the total.

If the miRNA recognition sequence binds to miRNA expressed in the desired cells, the expression of the regulatory protein is suppressed, thus distinguishing the cell type from others that do not contain the miRNA and express the protein.

On top of the problem recognition and methodology development, the article in Nature Energy also provides an initial approach to how the storage cell can protect itself from the reactive oxygen species.

Emotiv solved this brain — computer interface problem with the help of a multidisciplinary team that included neuroscientists, who understood the brain at a systems level (rather than individual cells), and computer engineers with a knack for machine learning and pattern recognition.

It may also explain why primates are so good at facial recognition and how we can potentially distinguish among billions of different people without needing an equally massive number of face cells.

Altering proteins in one part of the virus to achieve a certain benefit, such as more efficient gene transfer or reduced recognition by host immune cells, could end up destroying the structural integrity of the entire shell.

Personable brain cells: Neurons as virtuosos of face, object recognition.

Although the amygdala's importance in face recognition and emotional assessment is well - known, little is understood about how these processes work, but research led by investigators at Cedars - Sinai and the California Institute of Technology has found that at least some of the brain cells that specialize in recognizing emotions may represent judgments based on the viewer's preconceptions rather than the true emotion being expressed.

[Xinghua Shi et al., «Cell entry of one - dimensional nanomaterials occurs by tip recognition and rotation»] As nanotubes may have medical applications, making them safe is key.

The Clinton cell New research suggests that an individual brain cell is capable of complex pattern recognition.

Most neuroscientists adhere to the pixel view of neurons, arguing that individual cells can't possibly be clever enough to make sense of a concept as subtle as Rocky; after all, the world's fastest supercomputers have difficulty performing that pattern - recognition feat.

In volunteers who received a BCG vaccination, she observed an increase in cytokine production (proteins that control immune cells) and in the number of receptors that play a role during the recognition of intruders.

This is a fitting recognition of Sir Martin's ground - breaking research on embryonic stem cells.

Whilst such studies provide a reservoir of genes involved in bacterial recognition and degradation in vitro the situation in vivo where hemocytes can interact with other immune cells to optimize immune responses is likely to be more complex.

Receptors are proteins that are usually located on the external surface of the cell membrane; they provide specific recognition sites for messenger substances such as hormones, neurotransmitters and growth factors.

Since T cells can only recognize neoantigens that are «presented» to them by HLA molecules of the immune system, a key step in making the vaccine is using computer algorithms to predict which neoantigen peptides will bind strongly to the HLA molecules for recognition by T cells.

Zelig Eshhar and colleagues first use the T - body approach, employing chimeric receptors composed of an antibody recognition unit linked to T cell activation domains, to redirect T cells to recognize and attack tumor cells.

MCB is pleased to announce that Kevin Eggan, Assistant Professor of Molecular and Cellular Biology is a recipient of this year's MacArthur «genius» award in recognition of his stellar contribution to stem cell research.

«We have experiments in mice that show that the combined use of PD - 1 antibody and poly - IC is synergistic for the recognition of tumors and an antitumor response mediated by T - cells,» says Dr. Esteban Celis, co-leader of the Cancer Immunology, Inflammation and Tolerance program at the Georgia Cancer Center at Augusta University.

BAI1 has an apparently separate function as an «engulfment receptor,» allowing the recognition and internalization of dying cells.

Group 1 CD1 - restricted T cells and the pathophysiological implications of self - lipid antigen recognition.

TLR9 - dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function.

MAIT cells can be activated either through direct recognition of microbial ligands or by inflammatory cytokines such as IL - 12 and IL - 18.

On the flip side, improper recognition of self - antigens by T cells is the primary cause of most autoimmune diseases.

In addition, they hope to take the spatial recognition experiments to the next level using a new microscopy technology that could show simultaneous activity in both subclasses of pyramidal cells in a freely moving mouse.

CRI presents the Coley Award to Thierry Boon, for the isolation of genes responsible for mutation - induced production of cancer antigens by T cells, and to Rolf M. Zinkernagel, for landmark discoveries about MHC restriction of T cell recognition.

The researchers then used a dynamic force - scanning probe microscope for single - molecule force spectroscopy as well as antibody - recognition force microscopy (Ig - RFM) to map the locations of MtrC and OmcA on the surface of live Shewanella cells.

Timothy Springer, with colleagues Michael L. Dustin and Charles A. Dinarello, identifies and characterizes adhesion molecules, a class of cell surface proteins that function in the interactions of immune cells with other cells, including antigen - specific recognition and cell trafficking: integrin LFA - 1 involved in cytoskeleton and signaling, and intracellular adhesion molecules (ICAMs), which are binding partners (ligands) for LFA - 1 and are increased in inflammatory and autoimmune disease.

The capacity of DC to induce peripheral tolerance is a potential mechanism by which MSC could manipulate immunity in order to escape T cell recognition.

Lloyd Old, Thierry Boon, and colleagues develop the TNF release assay for mouse systems in which release of TNF by T cells could be used to assess specific T cell recognition, facilitating the cloning of human tumor antigens.

Immuno - oncology, as the name implies, recruits the immune system into the battle against cancer, either by boosting its existing but latent anti-tumor responses or honing its recognition of malignant cells.

In this context, the Lingwood laboratory studies B cell antibody responses to both HIV and influenza with the goal of 1) understanding how antigenic sites of vulnerability are initially perceived by specific germline B cell receptor (BCR) sequences and 2) how that recognition process can direct antibody affinity maturation toward production of broadly neutralizing anti-viral responses.

Self - recognition of the endothelium enables regulatory T - cell trafficking and defines the kinetics of immune regulation.

Areas of particular interest are host - pathogen interactions, pattern recognition receptors, cellular signaling and immunometabolism, and myeloid cell development.

Consequently both effector cells can operate in tandem, with NK cells providing a first line defense killing target cells that escape CTL recognition or show inadequate expression of self - MHC 142.

Innate immune recognition and response to cell death Kenneth RockUniversity of Massachusetts, USA 19th March 201804:15 pm Host: Falko Apel, MPIIB, Berlin Location: Max Planck Institute for Infection Biology, Seminar room 1/2 - Campus Charité Mitte

The Cell Surface Signalling Laboratory investigates the molecular basis of cellular recognition processes to identify new therapeutic targets for both genetic and infectious diseases.

Included among the numerous recipients of Mr. Sanford's gifts, that total more than one billion dollars, are: the Edith Sanford Foundation for Breast Cancer that was created in 2012 by a gift of $ 100 million in honor of Mr. Sanford's mother who died of breast cancer when he was four years old; the Sioux Valley Hospitals and Health System, which renamed itself Sanford Health in 2007, in recognition of a $ 400 million gift; a $ 125 million gift in 2014 to establish Sanford Imagenetics, a program that will integrate genomic medicine into primary care for adults; the University of California San Diego which received a $ 100 million gift for the creation of the Sanford Stem Cell Clinical Center in 2013 to accelerate the translation of stem cell research discoveries by advancing clinical trials and patient therapies; the Burnham Institute for Medical Research that received a $ 50 million gift in 2010, and recognized its appreciation for both this and a 2008 gift of $ 20 million to the Sanford Center for Childhood Disease research at Burnham by then changing its name to Sanford Burnham Medical Research Institute; a $ 70 million gift to establish a particle physics laboratory named the Sanford Underground Research Facility; and the San Diego Consortium for Regenerative Medicine which received a gift of $ 30 million in 2008 and expressed its gratitude by renaming itself the Sanford Consortium for Regenerative MedicCell Clinical Center in 2013 to accelerate the translation of stem cell research discoveries by advancing clinical trials and patient therapies; the Burnham Institute for Medical Research that received a $ 50 million gift in 2010, and recognized its appreciation for both this and a 2008 gift of $ 20 million to the Sanford Center for Childhood Disease research at Burnham by then changing its name to Sanford Burnham Medical Research Institute; a $ 70 million gift to establish a particle physics laboratory named the Sanford Underground Research Facility; and the San Diego Consortium for Regenerative Medicine which received a gift of $ 30 million in 2008 and expressed its gratitude by renaming itself the Sanford Consortium for Regenerative Mediccell research discoveries by advancing clinical trials and patient therapies; the Burnham Institute for Medical Research that received a $ 50 million gift in 2010, and recognized its appreciation for both this and a 2008 gift of $ 20 million to the Sanford Center for Childhood Disease research at Burnham by then changing its name to Sanford Burnham Medical Research Institute; a $ 70 million gift to establish a particle physics laboratory named the Sanford Underground Research Facility; and the San Diego Consortium for Regenerative Medicine which received a gift of $ 30 million in 2008 and expressed its gratitude by renaming itself the Sanford Consortium for Regenerative Medicine.

Pisabarro, M. T.; Leung, B; Kwong, M.; Corpuz, R.; Frantz, G. D.; Chiang, N.; Vandlen, R.; Diehl, L. J.; Skelton, N.; Eaton, D.; Schmidt, K. N. Novel Human Dendritic Cell - and Monocyte - attracting Chemokine - like Protein Identified by Fold Recognition Methods Journal of Immunology, 176, 2069 — 2073 (2006)

We also identify divergent families of putative secreted polypeptides that may reduce immune recognition, candidate regulators of host - cell transformation, and a Theileria - specific protein domain [frequently associated in Theileria (FAINT)-RSB- present in a large number of secreted proteins.

This new marker of senescent cells is recognized by a naturally occurring IgM antibody that belongs to the innate immune system and is likely to be involved in a natural mechanism of immune recognition and clearance of senescent cells.