Sentences with phrase «cell replacement therapy»
This brings together the two leaders in cell replacement therapies for diabetes.
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Therefore, numerous research activities address these issues in order to provide beta cell replacement therapy to a broader cohort of patients with diabetes.
The findings may represent a first step toward developing patient - specific cell replacement therapy for type 1 diabetes.
Several clinical trials are testing cell replacement therapies to treat spinal cord injuries.
Similarly, in the laboratory we've been studying cell replacement therapy.
Cell replacement therapies require clinically safe stem cells that can be used to generate many (possibly all) types of cells.
The documentary, called The Human Trial, follows the company and collaborators as ViaCyte is advancing the first stem cell - derived islet cell replacement therapy for type 1 diabetes through clinical trials.
This finding could advance the developing of cell replacement therapy for individuals with diabetes, perhaps resulting in an effective substitute for organ transplants.
About ViaCyte ViaCyte is a privately - held regenerative medicine company developing novel cell replacement therapies as potential long - term diabetes treatments to reduce the risk of hypoglycemia and diabetes - related complications.
San Diego, May 22, 2017 — ViaCyte, Inc., a privately - held leading regenerative medicine company, announced today that the U.S. Food and Drug Administration (FDA) has allowed the company's Investigational New Drug Application (IND) for the PEC - Direct ™ product candidate, a novel islet cell replacement therapy in development as a potential cure for patients with type 1 diabetes who are at high risk for acute life - threatening complications.
At ViaCyte we are dedicated to developing novel cell replacement therapies as potential long - term diabetes treatments to reduce the risk of hypoglycemia and diabetes - related complications.
His lab is at the forefront of developing cell replacement therapies for Parkinson's disease.
«Our long term goal is to develop a personalized cell replacement therapy using a patient's own cells to treat boys with Duchenne,» said Hicks.
By contrast, cell replacement therapies hold promise for permanently restoring natural patterns of hormone secretion while avoiding the need for costly, lifelong treatments.
These patients have a particularly urgent unmet medical need and could benefit greatly from cell replacement therapy.»
Behavioural recovery on simple and complex tasks by means of cell replacement therapy inunilateral 6 - hydroxydopamine - lesioned mice
ViaCyte's VC - 01 ™ product candidate, a first - in - class cell replacement therapy for the treatment of type 1 diabetes, is currently being evaluated in a Phase 1/2 trial called STEP ONE, or Safety, Tolerability, and Efficacy of VC - 01 Combination Product in Type One Diabetes.
Information on the clinical testing of ViaCyte's implantable cell replacement therapies can be found at Clinicaltrials.gov.
Understanding how heart muscle cells, or cardiomyocytes, change in space improves efforts for studying disease, screening drugs and conducting cell replacement therapy for future space missions.
ViaCyte Announces First Patients Implanted with PEC - Direct Islet Cell Replacement Therapy in International Clinical Trial
STEP ONE is the first trial in the world investigating a stem cell - derived beta cell replacement therapy for diabetes.
«You can manipulate stem cells and propagate them in a dish, but many recipients of stem cell replacement therapies will be older individuals.
Beyond Type 1 Provides Grant to ViaCyte to Support Research and Development of Cell Replacement Therapies for Type 1 Diabetes
San Diego, August 1, 2017 — ViaCyte, Inc., a privately - held, leading regenerative medicine company, announced today that the first patients have been implanted with the PEC - Direct ™ product candidate, a novel islet cell replacement therapy in development as a functional cure for patients with type 1 diabetes who are at high risk for acute life - threatening complications.
ViaCyte is advancing two novel cell replacement therapies as potential long - term type 1 diabetes treatments.
«These events offer several venues and platforms to share the exciting progress ViaCyte is making in developing novel cell replacement therapies for diabetes,» said Paul Laikind, PhD, President and CEO of ViaCyte.
The company is the first to advance an encapsulated islet cell replacement therapy for type 1 diabetes into clinical trials.
Moreover, by uncovering a hitherto unknown mechanism mediating neuronal differentiation, the study by Makeyev and co-authors should facilitate development of novel cell replacement therapies for neurological and neurodegenerative diseases.
The isolation of human embryonic stem cells by James Thomson and his colleagues in 1998 now offers the prospect of similar advances for human systems and the promise of a new modality of medicine — cell replacement therapy.
But for cell replacement therapy to realize its potential, I anticipate that scientists must solve the developmental code, the set of rules that govern the formation of tissues, organs, and beings from the original single cell — the zygote.
But in patients with type 1 diabetes, beta - cell replacement therapy is likely doomed to failure because the new cells might fall victim to the same autoimmunity that destroyed the original cells.
«For the broad application of stem cell - derived pituitary cells in the future, cell replacement therapy may need to be customized to the specific needs of a given patient population,» Zimmer says.
With these findings, Helmholtz Zentrum München scientists have discovered key molecular functions of stem cell differentiation which could be used for beta cell replacement therapy in diabetes.
An EU - funded research project («HumEn»), in which Lickert and his team are participating, shall provide further insights in the field of beta - cell replacement therapy.
So this will guide us toward a better strategy for cell replacement therapies.»
However, the study led by Pyle found that the current methods are inefficient; they produce immature cells that are not appropriate for modeling Duchenne in the laboratory or creating a cell replacement therapy for the disease.
«Skeletal muscle created from stem cells: Discovery is major step towards a stem cell replacement therapy for Duchenne Muscular Dystrophy.»
The findings are a major step towards developing a stem cell replacement therapy for muscle diseases including Duchenne Muscular Dystrophy, which affects approximately 1 in 5,000 boys in the U.S. and is the most common fatal childhood genetic disease.
Our long - term goal, therefore, is to explore the potential to genetically disrupt both ccr5 and cxcr4 for cell replacement therapies in HIV infected individuals, and in the case of cxcr4 do so in a way that specifically targets CXCR4 on T cells and not the many other cell types on which it is expressed.
«An islet cell replacement therapy could be significant for patients with this type of high - risk diabetes.»
«The loss of insulin - producing beta cells leads to type 1 diabetes, making it an ideal target for cell replacement therapy,» said James Shapiro, MD, PhD, FRCSC, Director of the Clinical Islet Transplant Program, University of Alberta.
The rsPSCs were easier to grow in the laboratory than conventional human pluripotent stem cells and offered advantages for large - scale production and gene editing (altering a cell's DNA), both desirable features for cell replacement therapies.
The cells generated in the Zeng lab may not only provide a potential unlimited source for cell replacement therapy for Parkinson's disease, but also offer an unprecedented opportunity to develop screening models for assessing small molecule drugs and to clarify the mechanisms of disease.
ViaCyte's PEC - EncapTM (also known as VC - 01TM) product candidate is the first pluripotent stem cell - derived islet cell replacement therapy for the treatment of type 1 diabetes in clinical - stage development.
For the first time, researchers demonstrate long term success of a cell replacement therapy using autologous induced pluripotent stem cell derivatives
Our goal is to identify means to enhance β - cell neogenesis from these progenitors, also present in mammals, as a cell replacement therapy for diabetes.
Our research goal is to understand the molecular and cellular events required for pancreatic β - cell regeneration, and apply this knowledge towards the development of cell replacement therapies for diabetes.