For the first time, researchers demonstrate long term success of
a cell replacement therapy using autologous induced pluripotent stem cell derivatives
«Our long term goal is to develop a personalized
cell replacement therapy using a patient's own cells to treat boys with Duchenne,» said Hicks.
Not exact matches
HSCT is effectively
used today as a form of «
replacement»
therapy for patients with hard - to - treat blood cancers, providing healthy
cells from either the patient (autologous transplantation) or from a donor (allogeneic transplantation) to better equip patients to fight the disease on their own.
With these findings, Helmholtz Zentrum München scientists have discovered key molecular functions of stem
cell differentiation which could be
used for beta
cell replacement therapy in diabetes.
This information could then be
used to prompt embryonic stem
cells to differentiate in the culture dish into neurons for potential
use in
cell -
replacement therapy.
Basically what was happening when you
use a hematopoietic stem
cell to correct an inherited metabolic disease is that through engraftment of that
cell you are allowing that
cell to become the
replacement source for the missing enzyme or other factor - almost like a cellular form of gene
therapy or, as I call it, «poor man's gene
therapy».
While many important developments impacted the field, two that garnered significant public, political and scientific attention in 2016 were the proliferation of clinics
using unproven stem
cell «
therapies,» and the steps forward in therapeutic modification of human oocytes (unfertilized eggs) through a process called mitochondrial
replacement therapy (MRT).
In addition, we
use our expertise to facilitate the development of functionally mature beta
cells from embryonic stem
cells for
cell replacement therapies of type 1 diabetes.
In addition, the funding will be
used to support other operations including the continued development of the PEC - Encap ™ product candidate, ViaCyte's stem
cell - derived islet
replacement therapy that is being developed as a treatment for all diabetes patients who require insulin to control their disease.
Cell replacement therapies require clinically safe stem
cells that can be
used to generate many (possibly all) types of
cells.
Ultimately, we
use all this information to establish innovative culture techniques for generating unlimited neural stem
cell sources for the derivation of specific types of clinically relevant neuronal or glial
cells, for their
use in disease modelling and drug discovery platforms, and towards refining their efficacy for future
cell replacement - based
therapy.
The new iPS
cells generated
using novel methods may represent biomedically - and clinically - ideal
cells, providing potential platforms for studying human disease mechanisms and achieving the long - term goal of personalized
cell -
replacement therapy.
Importantly, because it is already approved for clinical
use, amiodarone HCL may have clinical applications in
cell replacement therapies by selectively removing only the unwanted undifferentiated NSCs during the pre-transplant period.
Therefore, Hormone
Replacement Therapy (HRT) medications do not fit into hormone
cell receptors like BHRT medications; this mis - fit in molecular structure of HRT appears to have created some of the health problems associated with HRT Hormone
Therapy which has been discussed in the media over the past few years (the Women's Health Initiative Study (WHI) was released in July 2002 indicating health risks associated with synthetic HRT
use).
How and Where Estrogens Are Made and
Used in the Body Estrogen and
Cell Division How Estrogen Affects a Woman's Body The Estrogen Dominance Syndrome The Myth of Estrogen in Hormone
Replacement Therapy What Are Normal Estrogen Levels?
Stem
cell therapy offers the possibility of
using these stem
cells to grow into
replacements for injured or diseased tissues such as bone, cartilage, muscle, nerves, and so on.