Sentences with phrase «cell reprogramming in»

Cells reprogrammed in living mice (green) can contribute to both the placenta and body tissues of a developing mouse.

Not exact matches

By treating biology as software and reprogramming cells to treat diseases and other ailments, humans have already made tremendous progress in medicine, Kurzweil said Sunday.

Bellicum is among the flurry of biotechs investing heavily into cell therapies such as experimental chimeric antigen receptor T - cell (CAR - T) treatments for cancer (this is the next - gen treatment that involves reprogramming immune cells to become cancer killers and has shown promise in blood cancers, which Bellicum specializes in).

About half of the patients in a Kymriah study got cytokine - release syndrome, a response to the reprogrammed cells running loose in the body.

We're entering a new frontier in medical innovation with the ability to reprogram a patient's own cells to attack a deadly cancer.

It is far more likely, however, that the egg - cell cytoplasm with its stripping factor will reprogram all the genetic material including the alterations made in the donor nucleus that were intended to prevent the creation of the zygote.

The second biological objection is that «the egg - cell cytoplasm» will «reprogram all the genetic material including the alterations made in the donor nucleus that were intended to prevent the creation of the zygote.»

The term «oocyte assisted reprogramming» suggests that the egg cell will merely assist in reprogramming.

This hypothesis underestimates the opposing power of the egg cell cytoplasm to reprogram the genes in the donor - cell nucleus.

A few months ago, a team at Harvard succeeded in reprogramming cells using a virus that did not integrate into the cell's DNA.

In 2005, before a Congressional hearing in the U.S., Prof. George Q. Daley of Harvard spoke forcefully and influentially about the necessity for embryonic stem - cell research to go ahead, and dismissed suggestions that one could work instead with «induced pluripotent stem cells» («iPS», i.e. stem cells reprogrammed from some cells of a living adultIn 2005, before a Congressional hearing in the U.S., Prof. George Q. Daley of Harvard spoke forcefully and influentially about the necessity for embryonic stem - cell research to go ahead, and dismissed suggestions that one could work instead with «induced pluripotent stem cells» («iPS», i.e. stem cells reprogrammed from some cells of a living adultin the U.S., Prof. George Q. Daley of Harvard spoke forcefully and influentially about the necessity for embryonic stem - cell research to go ahead, and dismissed suggestions that one could work instead with «induced pluripotent stem cells» («iPS», i.e. stem cells reprogrammed from some cells of a living adult).

It also should relieve the worries of the scholars involved with the journal Communio ¯ the use of oocytes in epigenetic reprogramming was one of the major reasons they feared the resulting cell was a disabled embryo.

He has more than fifteen years» experience in the life science industry, including the product development, market development and commercialization of cells, scaffolds, cell reprogramming tools and cell culture media for regenerative medicine and bioprocessing applications.

However, in 2007 Professor Wilmut announced that he had decided to change to an alternative method of research pioneered in Japan, known as direct reprogramming or «de-differentiation», which could create human embryonic cells without using human eggs or cloning human embryos.

In the direct reprogramming, the researchers exposed the adult skin cells to a specific mix of signaling molecules the scientists» past research had found would convert healthy skin cells directly into a type of brain cell called medium spiny neurons, without intermediate steps along the way.

To solve these problems, Hingtgen's group wanted to see whether they could skip a step in the genetic reprogramming process, which first transforms adult skin cells into standard stem cells and then turns those into neural stem cells.

Mouse tumors injected directly with the reprogrammed stem cells shrank 20 - to 50-fold in 24 — 28 days compared with nontreated mice.

«In theory, we could model progression of the disease by reprogramming skin cells from patients at a range of ages, including before symptoms begin.

The MYC protein — which is one of the molecules used to reprogram iPSCs from adult cells — likely plays a role in dictating which sites in the genome are randomly methylated during the reprogramming process, the researchers hypothesized.

To develop their «disease in a dish» model, the team took skin cells from patients with Allan - Herndon - Dudley syndrome and reprogrammed them into induced pluripotent stem cells, which then can be developed into any type of tissue in the body.

Previous failures in reprogramming primate cells probably happened because the egg ran into roadblocks — portions of the body cell's DNA known as reprogramming - resistant regions, say study coauthor Mu - ming Poo, director of the Institute of Neuroscience at the Chinese Academy of Sciences in Shanghai, and his colleagues.

Adding ascorbic acid to culture medium could help overcome the main roadblock in reprogramming human, mouse cells into iPS cells

Partial reprogramming of cells within prematurely aging mice's bodies extended the rodents» average life span from 18 weeks to 24 weeks, researchers report December 15 in Cell.

Eventually, Lim hopes that reprogrammed cells will measure glucose levels in the pancreases of diabetics and trigger a biological insulin response, or even cure cancer.

Scientists use cell reprogramming techniques to produce cells in the lab so that they can study diseases.

Nevertheless, Vallier is concerned about the number of changes in the reprogrammed cell lines.

Reprogramming involves inducing the expression of four factors, called Yamanaka factors, in cells.

In a groundbreaking study that provides scientists with a critical new understanding of stem cell development and its role in disease, UCLA researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research led by Dr. Kathrin Plath, professor of biological chemistry, have established a first - of - its - kind methodology that defines the unique stages by which specialized cells are reprogrammed into stem cells that resemble those found in the embryIn a groundbreaking study that provides scientists with a critical new understanding of stem cell development and its role in disease, UCLA researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research led by Dr. Kathrin Plath, professor of biological chemistry, have established a first - of - its - kind methodology that defines the unique stages by which specialized cells are reprogrammed into stem cells that resemble those found in the embcell development and its role in disease, UCLA researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research led by Dr. Kathrin Plath, professor of biological chemistry, have established a first - of - its - kind methodology that defines the unique stages by which specialized cells are reprogrammed into stem cells that resemble those found in the embryin disease, UCLA researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research led by Dr. Kathrin Plath, professor of biological chemistry, have established a first - of - its - kind methodology that defines the unique stages by which specialized cells are reprogrammed into stem cells that resemble those found in the embCell Research led by Dr. Kathrin Plath, professor of biological chemistry, have established a first - of - its - kind methodology that defines the unique stages by which specialized cells are reprogrammed into stem cells that resemble those found in the embryin the embryo.

Further ahead, he is looking to an emerging technology known as induced pluripotent stem cells (iPSCs), in which adult cells are reprogrammed to be like embryonic stem cells so they can transform into any type of cell.

«Resistance to reprogramming also helps to explain why reprogramming takes place only in a very small proportion of the starting cells.»

Molecular characterization of the cells that undergo cell fate transition upon oncogenic Pik3ca expression demonstrated a profound oncogene - induced reprogramming of these newly formed cells and identified gene expression signatures, characteristic of the different cell fate switches, which was predictive of the cancer cell of origin, tumour type and clinical outcomes in women with breast cancers.

A group in Japan hopes to test a similar approach in humans using stem cells from reprogrammed adult cells within the next three years.

One called salinomycin stood out because it killed the reprogrammed cells, but not healthy cells, and was easy to obtain in large quantities.

But the methods used to reprogram cells can damage their DNA, and the iPS cells may not behave in exactly the same way as embryonic stem cells.

The team induced expression of Yamanaka factors in all cells of the organism using their partial reprogramming approach.

Ding's team took cells called fibroblasts from the connective tissues of mouse fetuses and bathed them in a cocktail of the four polyarginine - tagged proteins for 12 hours, then they removed the reprogramming proteins for 36 hours, and repeated this cycle four times over.

Plath's team found that the changes that happen in cells during reprogramming occur in a sequential stage - by - stage manner, and that importantly, the stages were the same across all the different reprogramming systems and different cell types analyzed.

In this study, partial reprogramming of cells in vitro reduced DNA damage accumulation and restored nuclear structurIn this study, partial reprogramming of cells in vitro reduced DNA damage accumulation and restored nuclear structurin vitro reduced DNA damage accumulation and restored nuclear structure.

Scientists have rolled back time for live mice through systemic cellular reprogramming, according to a study published December 15 in Cell.

While the process usually proceeds in a one - way direction, artificially inducing the activity of key transcription factors can reprogram differentiated cells back into a stem - like state, a discovery honored with the 2012 Nobel prize.

The researcher Pia Cosma and her team have used the cell fusion mechanism to reprogram the neurons in the retina.

This is how treatments based on a type of white blood cell called T - cells are curing some cancers, rather than just slowing their advance (see «Cancer meets its nemesis in reprogrammed blood cells «-RRB-.

In 2006, Japanese scientists figured out how to reprogram specialized cells, such as those in skin, so that they act like embryonic stem cellIn 2006, Japanese scientists figured out how to reprogram specialized cells, such as those in skin, so that they act like embryonic stem cellin skin, so that they act like embryonic stem cells.

Unpublished results from the researchers hint that significantly fewer anomalies are seen in iPS cells created via virus - free reprogramming strategies, such as ones that use proteins or small - molecule drugs.

Testing each of these factors for their ability to return differentiated tumor cells to a stem - like state, identified a combination of four — POU3F2, SOX2, SALL2 and OLIG2 — that was able to reprogram differentiated tumor cells back into glioblastoma stem cells, both in vitro and in an animal model.

The act of reprogramming cells to make them as capable as ones from embryos apparently can result in aberrant cells that age and die abnormally, suggesting there is a long way to go to prove such cells are really like embryonic stem cells and can find use in therapies.

They reprogrammed the skin cells, rejuvenating them into an embryolike state (using the four - gene approach described in 2007).

This year those breakthroughs include tools for reprogramming living cells and rendering lab animals transparent; ways of powering electronics with sound waves and saliva; smartphone screens that correct for the flaws in your vision; Lego - like atomic structures that could produce major advances in superconductivity research; and others.

These techniques include: human tissue created by reprogramming cells from people with the relevant disease (dubbed «patient in a dish»); «body on a chip» devices, where human tissue samples on a silicon chip are linked by a circulating blood substitute; many computer modelling approaches, such as virtual organs, virtual patients and virtual clinical trials; and microdosing studies, where tiny doses of drugs given to volunteers allow scientists to study their metabolism in humans, safely and with unsurpassed accuracy.

Research in mice and human cells suggests that a fasting - mimicking diet may reprogram pancreas cells that are unable to produce insulin and enable them to repair themselves and start making it.