Sentences with phrase «cell reprogramming techniques»

Scientists use cell reprogramming techniques to produce cells in the lab so that they can study diseases.

But now, a team of researchers at Oregon Health and Science University in Portland, Oregon, has used a unique cloning and cell reprogramming technique to create a fresh piece of tissue or stem cells that perfectly match and is compatible with the skin of the affected patient.

Not exact matches

The team demonstrated that cell sex considerably influenced cellular uptake of nanoparticles and found that cells from men and women responded differently to reprogramming techniques used to enhance the ability of the cells to differentiate into a greater variety of cell types.

These techniques include: human tissue created by reprogramming cells from people with the relevant disease (dubbed «patient in a dish»); «body on a chip» devices, where human tissue samples on a silicon chip are linked by a circulating blood substitute; many computer modelling approaches, such as virtual organs, virtual patients and virtual clinical trials; and microdosing studies, where tiny doses of drugs given to volunteers allow scientists to study their metabolism in humans, safely and with unsurpassed accuracy.

CTL119 manufacturing begins with a patient's own T cells, some of which are removed and then reprogrammed in Penn's Clinical Cell and Vaccine Production Facility with a gene transfer technique designed to teach the T cells to target and kill tumor cells.

Techniques that reprogram cells have revolutionized the stem cell field.

Since Yamanaka's breakthrough, dozens of groups have reported other ways of reprogramming cells as well as techniques to control differentiation of stem cells into neurons, cardiovascular cells, and other tissues of interest for regenerative medicine.

Thanks to a promising technique known as cell reprogramming, this science fiction scenario may soon become reality.

For the new study, the team used a cell - reprogramming technique (similar to those used to reprogram skin cells into stem cells) to generate human DRG - type sensory neurons from ordinary skin cells called fibroblasts.

The group combines several cutting - edge single molecule imaging techniques to study how protein organization, dynamics and stoichiometry relate to protein function in several fundamental biological processes, such as intracellular transport, autoimmune neurological disorders or stem cell reprogramming.

The breakthrough was possible because the research team used conditional reprogramming (CR), a laboratory technique, developed and described by Liu, Richard Schlegel, MD, PhD, director of the CCR, and their colleagues at Georgetown in 2011, that makes it possible to continuously grow cells in a laboratory indefinitely.

But the favored reprogramming technique, somatic cell nuclear transfer (SCNT), otherwise known as research cloning, is fraught with ethical pitfalls as well as technical difficulties because it entails creating a human embryo by inserting an adult cell nucleus into an ooctye.

They also want to see if they can use a variation of the technique to reprogram human cells placed inside a mouse.

In the new research, Prins and Liau used a technique called adoptive cell transfer, which involves extracting and growing immune cells outside of the body, then reprogramming them with a gene known as New York Esophageal Squamous Cell Carcinoma, or NY - ESO cell transfer, which involves extracting and growing immune cells outside of the body, then reprogramming them with a gene known as New York Esophageal Squamous Cell Carcinoma, or NY - ESO Cell Carcinoma, or NY - ESO - 1.

To make iPS cells, scientists use a technique called cellular reprogramming.

For example, using existing techniques, fewer than one percent of adult skin cells are reprogrammed into iPSCs.

However, researchers have found ways to reprogram these adult cells so their identities are no longer fixed and they can theoretically become any type of cells; these reprogramming techniques led researchers to the creation of iPS cells.

Using a technique known as transcription factor reprogramming, first described by the Japanese stem - cell pioneer Shinya Yamanaka and his colleagues in 2007, Ku «rebooted» the skin cells» genetic machinery to turn them into stem cells.

The crux of the discovery, published online Tuesday by the journals Cell and Science, is a «direct reprogramming» technique that adds a cocktail of four genetic factors to run - of - the - mill human skin cells.

In the several years since those first reports, new advances in the derivation of hiPSCs from various tissue sources (including those from human patients) and using diverse reprogramming techniques, and in their use as a pluripotent cell source in the induced differentiation of a wide array of somatic cell types, have appeared with almost startling rapidity.

This technique, pioneered by Gladstone Investigator and 2012 Nobel Laureate Shinya Yamanaka MD, PhD, allows scientists to reprogram adult skin cells into cells that are virtually identical to stem cells.

The choice of the somatic cell for reprogramming, the reprogramming technology chosen, and the differentiation techniques utilised, all work synergistically towards the production of mature iPSCs - derived chondrocytes which are comparable to patient - derived chondrocytes, in line with Good Manufacturing Practice guidelines for an «off - the - shelf» stem cell product.

Other techniques can reprogram «adult» cells in the human body taken from skin, for example — but the cells still carry baggage from their previous state.