Sentences with phrase «cell reprogramming work»

This research builds on the ground - breaking cell reprogramming work of their Gladstone colleague, Shinya Yamanaka, MD, PhD.

Not exact matches

In 2005, before a Congressional hearing in the U.S., Prof. George Q. Daley of Harvard spoke forcefully and influentially about the necessity for embryonic stem - cell research to go ahead, and dismissed suggestions that one could work instead with «induced pluripotent stem cells» («iPS», i.e. stem cells reprogrammed from some cells of a living adult).

Work with skin cells reprogrammed to mimic embryos had suggested the mutation would be repaired in fewer than 30 percent of cells.

The research team from the Department of Biochemistry and Molecular Biology headed by Professor Susanne Mandrup are publishing a paper entitled «Browning of human adipocytes requires KLF11 and reprogramming of PPAR super-enhancers» in the January 1 edition of the scientific journal Genes & Development that describes their results from working with «brite» fat cells.

But like the medieval alchemists, today's cloning and stem cell biologists are working largely with processes they don't fully understand: What actually happens inside the oocyte to reprogram the nucleus is still a mystery, and scientists have a lot to learn before they can direct a cell's differentiation as smoothly as nature's program of development does every time fertilized egg gives rise to the multiple cell types that make up a live baby.

Working with human breast cancer cells and mouse models of breast cancer, scientists identified a new protein that plays a key role in reprogramming cancer cells to migrate and invade other organs.

Researchers might generate personalized brain organoids from the reprogrammed skin cells of individuals with, say, schizophrenia and test which medications work best for patients with particular genetic profiles of the illness.

Researchers are also working to develop a trial where they will reprogram CAR T cells to identify the CD19 and CD22 proteins simultaneously, enabling them to target the cancer cells from more than one angle with the initial round of T - cell immunotherapy.

As many as a dozen major labs, he says, have since tried but failed to make reprogramming work in human cells.

«Cell reprogramming is revolutionising medicine, yet surprisingly little is known about how it actually works,» says stem cell expert Vincent Pasque, assistant professor at KU Leuven, BelgCell reprogramming is revolutionising medicine, yet surprisingly little is known about how it actually works,» says stem cell expert Vincent Pasque, assistant professor at KU Leuven, Belgcell expert Vincent Pasque, assistant professor at KU Leuven, Belgium.

As a result, many of the studies published up to now describe only two or three patient stem cell lines,» says David Panchision, who oversees the NIMH's National Cooperative Reprogrammed Cell Research Group (NCRCRG) program, which supported this wcell lines,» says David Panchision, who oversees the NIMH's National Cooperative Reprogrammed Cell Research Group (NCRCRG) program, which supported this wCell Research Group (NCRCRG) program, which supported this work.

In recent years, Muotri and colleagues have created in vitro cellular models of autism using reprogrammed induced pluripotent stem cells (iPSC) derived from discarded baby teeth of children with autism, work dubbed the «tooth fairy project.»

The award was given for their work showing that mature cells can be reprogrammed into pluripotent stem cells.

But Hochedlinger, whose group's paper appears in a new journal called Cell Stem Cell, stresses that researchers still need to study human cells to learn how to reprogram them and have no idea yet which approach would work better in the long run.

Previous work suggested they were as malleable as embryonic stem cells and so could be reprogrammed to make any kind of tissue.

Earlier work has shown that grafted stem cells reprogrammed to become neurons can, in fact, form new, functional circuits across an injury site, with the treated animals experiencing some restored ability to move affected limbs.

At the same time, the work provides new clues for successfully reprogramming cells in humans and advances in regenerative medicine and its medical applications.

Although no one knows exactly how Wnt works, other studies have suggested that the signals may cause cells around an injury to revert to a state similar to that of stem cells, allowing them to be reprogrammed to grow back the missing part.

The Lasker Foundation honored John Gurdon (top right) and Shinya Yamanaka (bottom right) for work on cell reprogramming and Brian Druker (top left), Nicholas Lydon (bottom left), and Charles

Instead the team is working with induced pluripotent stem cells, cells that have been reprogrammed to behave like embryonic stem cells, but can be made from a small sample of the intended recipient's own skin.

In 2006, Yamanaka took Gurdon's work to the next level by reprogramming adult mouse skin cells into induced pluripotent stem cells.

A better understand of the mechanism by which somatic cells are reprogrammed into pluripotent cells is critical to ongoing work to understand and to treat disease.

In their most recent work they report the preparation of reprogrammed (re --RRB- iNKT cells.

This work is an extension of a 2012 paper in the journal Cell, where Cooke showed that the viruses used to deliver the reprogramming genes were more than just vehicles.

«Our earlier work was the first to clearly show in vivo (in a living animal) that mature astrocytes can be reprogrammed to become functional neurons without the need of cell transplantation.

«Work in other organs has shown that reprogramming cells is rarely accomplished by manipulating a single factor,» Zuo said.

The work recently received a $ 1.7 million National Institutes of Health grant to delve into the mechanisms that occur as the cells reprogram, and to employ the cells for treating the Parkinson's - like symptoms in a mouse model of hypomyelinating disease.

His work has focused on discovering and characterizing novel small molecules that can control various cell fates and functions, including stem cell maintenance, activation, differentiation and reprogramming in various developmental stages and tissues.

Our work focuses on discovering and characterizing novel small molecules that can control cell fate and function in numerous cell types, including stem cell maintenance, activation, differentiation, and reprogramming in various developmental stages and tissues.

Scientists can now reprogram human skin cells to make working cells that resemble «medium spiny neurons», the type of brain cell that is most affected early in Huntington's disease.

Using this approach, immune cells are taken from a patient's bloodstream, reprogrammed to recognize and attack a specific protein found in cancer cells, then reintroduced into the patient's system, where they get to work destroying targeted tumor cells.

Taking this work a step further, in 2008, they were the first to show that skin cells could be reprogrammed into stem cells (becoming induced pluripotent stem cells, or iPS cells), then differentiated into specific dopamine neurons.

Clarke notes that this kind of work — reprogramming normal cells to replace damaged tissues or organs in regenerative medicine, or even growing cells from an individual's cancer to determine what the best treatment is — speaks to the doctrine rather than challenges it.

This classic work has inspired several generations of scientists to discover mechanisms of cell identity, which have informed a lot of the discoveries in stem cell biology and reprogramming that have followed.

Dr. Ding's work builds on the cell - reprogramming work of Gladstone Investigator Shinya Yamanaka, MD, PhD.

«The idea of reprogramming a cell from your body to become anything your body needs is very exciting,» said Longaker, who emphasized that the work involved not just a collaboration between his lab and Wu's, but also between the two Stanford institutes.

Dr. Ding's work revolves around chemical reprogramming — the use of small molecule drug mixtures to coax fibroblasts into becoming a variety of other cell types.

Yamanaka's initial work in reprogramming cells utilized mice, not human, embryonic stem cells, and he used the same method for human iPSC production.

Also, rather than using such compounds to reprogram cells all the way back to the pluripotent state, we are also working on more direct ways to change one type of cell directly into another.

However, there is still much work to be done to prove that the cells are safe particularly since even this newer method still uses retroviruses to tranfer the reprogramming factors.»

The work by Zhang and other researchers could potentially address those problems, since insulin - producing cells could be made from diabetic patients» own reprogrammed cells.

«As both a physician and a scientist, Dr. Takahashi embodies the ideal recipient because her work brings cellular reprogramming to patients,» says Gladstone president R. Sanders Williams, MD. «Mr. Ogawa's visionary support of translational stem cell research will help encourage and accelerate the progression of the field.»

This research builds on the groundbreaking cell - reprogramming work of another Gladstone scientist and UCSF professor of anatomy, Shinya Yamanaka, MD, PhD.

The University of Minnesota is setting up technology to work with the reprogrammed cells, said Jonathan Slack, director of the University's Stem Cell Institute.

The discovery of cell reprogramming by Shinya Yamanaka changed the way scientists see cell biology, but the details of how it works are still being defined.

Gladstone scientists study how human skin cells can be reprogrammed into induced pluripotent stem (iPS) cells, and they are working to refine the production of these cells.

All previous work on cellular reprogramming required adding external genes to the cells, making this accomplishment an unprecedented feat.

The choice of the somatic cell for reprogramming, the reprogramming technology chosen, and the differentiation techniques utilised, all work synergistically towards the production of mature iPSCs - derived chondrocytes which are comparable to patient - derived chondrocytes, in line with Good Manufacturing Practice guidelines for an «off - the - shelf» stem cell product.

Exactly how reprogrammed cells should be deployed clinically still needs to be worked out.

Dr. Ding's work builds on the cell - reprogramming work of another Gladstone scientist, Senior Investigator Shinya Yamanaka, MD, PhD.