Sentences with phrase «cell researchers against»

A case brought by two cardiac stem cell researchers against their institution for allegedly mishandling a misconduct investigation was dismissed by a federal judge in Massachusetts this week.

Not exact matches

Researchers found that NAD +, a natural molecule found in living cells, plants and food protects against autoimmune diseases by altering the immune response and turning «destructive» cells into «protective» cells.

Researchers used tissue and blood samples to show that the gammopathy (a precursor to myeloma) in both mice and patients with Gaucher disease is triggered by specific lipids, and that the antibodies made by tumor cells in nearly a third of myeloma patients are directed against such lipids.

The researchers tested the drug combinations against four different human cervical cancer cell lines.

More light leads to a greater flow of calcium, so the researchers are able to finely tune the calcium - dependent actions of immune cells to fight against invading pathogens or tumor cells.

Researchers for the past decade have focused on the T cell approach, based on studies showing that monkeys receiving such vaccines against simian immunodeficiency virus, related to HIV, lived longer or had lower viral levels than usual.

By releasing the brakes that tumor cells place on the immune system, researchers are developing a new generation of more powerful treatments against malignancy

He has also been an inveterate foe of abortion, a position that informed his repeated votes against expanding the number of human embryonic stem cell lines available to NIH - funded researchers during the George W. Bush administration.

«Protein isolated from baker's yeast shows potential against leukemia cells: Researchers performed in vitro trials to test the effect of L - asparaginase on acute lymphoblastic leukemia cells and published the results in Scientific Reports.»

When researchers screened a library of more than 200 drugs and related compounds for activity against embryonal subtype tumor cells from three patients, the most promising results involved drugs that increased oxidative stress in tumor cells.

The researchers believe this difference in B cell distribution among those with uncontrolled HIV adds to a list of reasons most people do not make effective antibodies against the virus.

In a series of laboratory experiments, the researchers found that antibodies against HSV - 1 remain in the trigeminal ganglion (a group of nerve cells that receives signals from the eyes and face and is a key site of HSV infection) long after active virus infection is cleared, and that these maternal antibodies can travel to the fetal trigeminal ganglia.

Tina Hesman Saey covered researchers» arguments for and against this type of genetic engineering in «Editing human germline cells debated» (SN: 5/30/15, p. 16).

The researchers studied two types of cells called effector T cells, which activate the immune system to defend our body against different pathogens, and regulatory T cells, which help control the immune system and prevent it from attacking healthy parts of its environment.

In nature, RNAi acts as a defence mechanism to protect cells against retroviruses, but it has been cleverly adapted by researchers.

The researchers showed how gelsolin works at the molecular level to protect cancer cells against a widely used chemotherapy drug called cisplatin.

In human donor cells and mouse experimental models, the researchers demonstrated that TSLP specifically targeted neutrophils — white blood cells that constitute the first line of defense against bacterial infections.

Researchers at the Center for Cell and Gene Therapy at Baylor College of Medicine, Texas Children's Hospital and Houston Methodist have developed an alternative treatment in which virus - specific cells protect patients against severe, drug - resistant viral infections.

La Jolla Institute scientist Shane Crotty, Ph.D., a respected vaccine researcher and member of one of the nation's top AIDS vaccine consortiums, showed that certain helper T cells are important for triggering a strong antibody response against HIV, the virus that causes AIDS.

Tests with kidney cancer and two human uterine sarcoma cell lines, one with multidrug resistance, showed that 10 of these new compounds were impressively potent against all three cell lines, the researchers reported.

In the current issue of Cell, Jing Liu, a graduate student researcher in the Chien lab at UMass Amherst working with the Laub lab at MIT, show that in the bacteria Caulobacter, a particular enzyme, Lon, can help defend against the effects of stress by cutting up and destroying small amounts of misfolded proteins.

Exploiting the same pre-clinical model used for their studies, the researchers are testing the efficacy of this kind of drug candidates against cancer stem cells, and the possibility of identifying combination regimens with standard chemotherapies with minimized toxic effects, with the perspective of their possible application for the treatment of human breast cancer.

► In a Thursday ScienceInsider, Kelly Servick reported that the case brought by heart stem cell researchers Piero Anversa and Annarosa Leri «against their institution,» Harvard Medical School and its affiliate, Brigham and Women's Hospital (BWH), «for allegedly mishandling a misconduct investigation was dismissed by a federal judge in Massachusetts this week.

Researchers from the Gladstone Institutes have used human cells to discover how blood flow in the heart protects against the hardening of valves in cardiovascular disease.

«In worldwide chemotaxis competition, researchers race cell lines to the finish line: Neutrophil - like cells balance speed against accuracy to race through microfluidic mazes.»

«Dengue immunity can protect against Zika virus: Researchers reveal dual Zika / dengue immunity conferred by cytotoxic T - cells.»

Researchers were able to quantify the protective effect of dexamethasone treatment in protecting both satellite glial cell and neuronal apoptosis; in contrast, meloxicam treatment was only effective in protecting against satellite glial cell apoptosis and only after prolonged administration.

By viewing this fusion as another disease imposed onto tumor cells, scientists could devise new therapies against metastasis, the researchers say in the May Nature Reviews Cancer.

When taken separately in low doses, resveratrol and grape seed extract are not as effective against cancer stem - cell suppression as when they are combined together, according to the researchers.

The researchers used a technique called activity - based protein profiling, which allowed them to screen the molecule's activity against a very large group of enzymes in living human cells.

National Institutes of Health researchers studying zebrafish have determined that a population of cells that protect the brain against diseases and harmful substances are not immune cells, as had previously been thought, but instead likely arise from the lining of the circulatory system.

In collaboration with researchers at the Lead Discovery Centre of the Max Planck Society in Germany, they developed an inhibitor molecule directed against the receptors that are regulated by Cbl - b in NK cells, the so called TAM - receptors.

In a study published in Nature this week, an international team led by researchers from the Faculty of Medicine at the University of Geneva (UNIGE), Switzerland, discovered how our cells defend themselves against HBV infection, but also how the virus fights back.

To use RNAi against the pest, the researchers first identified a gene the insect can't do without — one that encodes a cytoskeleton protein vital to maintaining a cell's shape.

The immune activation from the CAR cells was also met with resistance mechanisms, including an upregulation of immunosuppressive pathways which may work against the patient and for the tumor, the researchers found.

In the new method, the researchers isolated B cells from humans who had been vaccinated against — and therefore had built up specific antibodies to — the seasonal flu.

The researchers hope that the identification of these unique cell wall traits in FHB - resistant common wheat could help in breeding durum wheat varieties that are able to defend themselves against infection, and reduce fungal toxin contamination in food.

In a study using mice, the researchers found that using Dox and TRAIL in the pseudo-platelet drug delivery system was significantly more effective against large tumors and circulating tumor cells than using Dox and TRAIL in a nano - gel delivery system without the platelet membrane.

As the researchers have shown in various studies on mice, the widespread active ingredient sildenafil or a medication against pulmonary hypertension, for instance, can be used to reduce the number of white fat cells to the benefit of the brown fat cells and thus accelerate fat burning like a turbocharger.

Researchers also found that sequential use of an initial dose of chemotherapy first and then cannabinoids significantly improved overall results against the blood cancer cells.

Payne researches autoimmunity, and a few years ago, a postdoctoral researcher in her laboratory, Christoph T. Ellebrecht, MD, took an interest in CAR T cell technology as a potential weapon against B cell - related autoimmune diseases.

The researchers, therefore, wanted to study whether the vaccine also increased the risk of developing autoantibodies against beta cells in the pancreas and the occurrence of type 1 diabetes.

As an additional safety feature, the researchers introduced two mutations that weakened the virus's ability to combat the cell's defenses against infection, reasoning that the mutated virus still would be able to grow in tumor cells — which have a poor antiviral defense system — but would be eliminated quickly in healthy cells with a robust antiviral response.

Researchers are hopeful that the approach they used in this study of neuroblastoma may prove effective against some of the many other cancers also characterized by a surplus of MYC - family proteins in tumor cells.

Rather than the body's immune system destroying its own tissue by mistake, researchers at the University of Bristol have discovered how cells convert from being aggressive to actually protecting against disease.

Researchers at the Children's Medical Center Research Institute (CRI) at UT Southwestern have discovered that cells in the liver with whole genome duplications, known as polyploid cells, can protect the liver against cancer.

Helping to protect newborns and older patients against more severe effects of jaundice is the hope of University of Guelph researchers, who have shown how a liver enzyme protects cells from damage caused by the condition.

Mayo Clinic researchers now have discovered that Pten safeguards against tumor formation by keeping chromosome numbers intact when a cell splits into two daughter cells.

In experiments in animals, researchers from the University of Michigan Medical School showed that adding rapamycin to an immunotherapy approach strengthened the immune response against brain tumor cells.

Researchers have already quantified their abundance of these cell envelope proteins and are learning their basic function, and in continued studies will screen compounds for activity against some of them.