Sentences with phrase «cell researchers call»

Stem cell researchers call them «a major step in the right direction,» although some were disappointed that NIH didn't open the door to the use of embryos created for research purposes — including through somatic cell nuclear transfer (cloning) and parthenogenesis (from an unfertilized egg).

Not exact matches

So researchers, with limited success, have tried to build such a GPS directly into a new type of biological assassin called a «CAR - T cell.»

The researchers found that puffing activated a mechanosensitive channel protein called TRPV4, which is enriched in the membrane of neuronal axons and allows calcium ions to enter the cell.

From the embryonic stem cells, the researchers produced a type of tissue called retinal pigment epithelium (RPE).

In the direct reprogramming, the researchers exposed the adult skin cells to a specific mix of signaling molecules the scientists» past research had found would convert healthy skin cells directly into a type of brain cell called medium spiny neurons, without intermediate steps along the way.

The researchers used a drug called clorgyline to inhibit the activity of the MAOA enzyme; the drug disrupted the signaling system that led to cancer cell invasion and proliferation.

Then the researchers doused dengue - spreading mosquitoes with a chemical that shuts down the mosquitoes» ability to detect CO2 by blocking a receptor called neuron — cpA, a type of sensory cell found on a small pair of antennalike structures near the mouth called the maxillary palps.

The algorithm was built using tools the researchers developed to define how T cell receptors recognize a part of the antigen called the epitope.

Institute researchers also uncovered the parents (called progenitors) that produce dendritic cells.

Now, researchers at Washington University School of Medicine in St. Louis have shown, in mice, that the virus infects a rare type of intestinal cell called a tuft cell, so named because each cell sports a cluster of hairlike extensions on its surface.

In the journal Cell on July 27, researchers show how this DNA variant enhances the activity of a gene called endothelin - 1 (EDN1), which is known to promote vasoconstriction and hardening of the arteries.

Working in cell cultures and mice, researchers at Johns Hopkins have found that an experimental drug called fostamatinib combined with the chemotherapy drug paclitaxel may overcome ovarian cancer cells» resistance to paclitaxel.

Researchers then tested cell cultures and mouse models by using a gene editing process called CRISPR - Cas9 to demonstrate how the presence or absence of myomaker and myomerger — both individually and in unison — affect cell fusion and muscle formation.

The researchers — James Robl, a developmental biologist and his colleagues at the University of Massachusetts at Amherst, and Steve Stice at Advanced Cell Technology in Worcester, Massachusetts — inserted a marker gene fused with a gene for resistance to the chemical neomycin into a culture of connective tissue cells called fibroblasts.

At the same time, researchers have found that much smaller protein clusters called oligomers — made of only a few copies of these proteins — can be highly toxic to motor neuron - like cells grown in the lab and thus are more likely to be the chief causes of brain - cell death in these diseases.

Led by researchers at the Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James), the retrospective study suggested that a pattern of molecules called microRNA (miRNA) in tumor cells might predict patients» response to radiation therapy.

A new study by researchers at The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James) has identified a mechanism by which cancer cells develop resistance to a class of drugs called fibroblast growth factor receptor (FGFR) inhibitors.

When the researchers added a little of this bacterial byproduct to the mix, Fel d 1 activated a specific immune receptor on cells, called Toll - like receptor 4 (TLR4).

Two weeks after the experimental myocardial infarctions, the Seattle researchers injected 1 billion heart muscle cells derived from human embryonic stem cells, called human embryonic stem cell - derived cardiomyocytes, into the infarcted muscle.

The cells which the researchers have studied are called Purkinje cells and are located in the cerebellum.

The elevation in a growing embryo's temperature, called hyperthermia, impacts the activity of heat - sensitive channels that are present in cells necessary for an embryo's development, researchers report online October 10 in Science Signaling.

In science news around the world, scientists march in India to call for more research funding, a South Korean researcher who was enmeshed in a stem cell scandal a decade ago resigns from a newly created government position, Canada establishes a vast marine conservation area in the High Arctic, a highly regarded advocate for science is convicted of financial misdemeanors in Egypt, and more.

Specifically, the Mount Sinai study was designed to test whether pharmacological compounds designed to block the function of XPO1 / CRM1 could stop disease progression in mouse models that exhibit some of the characteristics of MS. Researchers found that two chemical agents (called KPT - 276 and KPT - 350) prevented XPO1 / CRM1 from shuttling cargo out of the nucleus of nerve cells, which protected them from free radicals and structural damage.

To block the FA repair pathway in leukemic cells, researchers tested the inhibition of a protein called mTOR (mammalian target of rapamycin).

The researchers found that, in response to the maximum tolerated doses of several commonly used chemotherapy drugs, breast cancer - associated fibroblasts secrete large amounts of cell signaling proteins called ELR + chemokines.

Researchers called them induced pluripotent cells, which are created by enticing cells to turn on genes normally found in embryonic stem cells.

Using a surgical technique called parabiosis to join the circulatory system of a young mouse with that of an old one, the researchers studied the effects of young blood on elderly cells, and vice versa.

Studying mice with injuries to the lining of the stomach, the researchers blocked the animals» ability to call on stem cells for help in the stomach.

The researchers observed that two drugs each killed a large fraction of the cells that had begun transitioning: dasatinib, a drug that targets the Src Family Kinase (SFK) and RK20449, a new drug in pre-clinical testing that specifically targets one of the SFK proteins called Hck.

In 2001, researchers at the Chinese Academy of Sciences in Shanghai reported that chronic morphine administration in rats activated glial cells called astrocytes in the spinal cord.

Researchers know that cells chop single genes into shorter pieces called exons, which they mix and match into one transcript for creating a protein.

University of Illinois researchers have developed a new technique to create a cell habitat of squishy fluids, called hydrogels, which can realistically and quickly recreate microenvironments found across biology.

University of Washington researchers have found that a calorie - restricted diet reduces the activity of a cell - signaling protein called TOR - 1 that may speed up cell aging.

In further test tube experiments, the researchers treated the immortalized white blood cells with both chemical and genetic blockers, called small interfering RNA (siRNA), designed to render either p70S6K or GRB10 nonfunctional.

The researchers believe the hammerhead shark reproduced by a type of asexual reproduction called automictic parthenogenesis, whereby an unfertilised egg is activated to behave as a normal fertilised egg by a small, nearly genetically identical cell known as the sister polar body.

The researchers found that having higher amounts of penile anaerobes was associated with higher production of biochemicals, called cytokines, capable of recruiting immune cells.

Researchers are also experimenting with another form of immunotherapy called adoptive cell transfer, which harvests and then reintroduces patients» tumor - infiltrating lymphocytes — cells with anti-tumor capabilities that dig deep behind enemy lines.

New research by a team of investigators at the Medical University of South Carolina (MUSC) directed by Xue - Zhong Yu, M.D., professor of Microbiology and Immunology, in collaboration with researchers at the University of Minnesota, demonstrates that one particular family of microRNAs (miRs), called miR -17-92, is responsible for the T - cell and B - cell pathogenicity that causes GVHD.

The researchers used a technique called laser scanning photostimulation to map the connections between individual subplate neuron cells in the brains of the mouse pups.

A new study by researchers at Sanford - Burnham Medical Research Institute (Sanford - Burnham) has found that a peptide called caerulein can convert existing cells in the pancreas into those cells destroyed in type 1 diabetes insulin - producing beta cells.

The researchers also found that treating the mice with a molecule called CTL - associated antigen - 4 immunoglobulin (CTLA4Ig) suppressed damage to liver cells infected with hepatitis B virus, suggesting that this might be a potential approach to treatment.

A promising alternative to hESCs emerged in 2006 when researchers produced so - called induced pluripotent stem cells (iPS) from ordinary tissue such as skin.

In this study, the researchers found that a specific population of immune cells called macrophages have the ability to secrete or produce a protective or healing factor known as Interleukin - 10 (IL - 10), which can interact with receptors on intestinal epithelial cells to promote wound healing.

For an even better understanding of VEGF production in those cells, the researchers investigated the role of a protein called VHL (von Hippel - Lindau), which normally keeps HIF levels low.

Now, researchers have discovered that non-beta cells in the pancreas can be transformed into insulin - producing cells, merely by exposing them to a growth factor called BMP - 7.

The team of researchers, led by yeast cell biologist Susan Lindquist of the University of Chicago, had demonstrated last year that a metabolic trait in yeast called [PSI +] could be passed from one generation to the next without changes in the yeast's DNA.

At that time, the plaintiffs — adult stem cell researchers James Sherley and Theresa Deisher — expect to file what's called a motion for summary judgment, which asks that the case be decided without a trial.

In a process called cellular reprogramming, researchers at Icahn School of Medicine at Mount Sinai have taken mature blood cells from patients with myelodysplastic syndrome (MDS) and reprogrammed them back into iPSCs to study the genetic origins of this rare blood cancer.

Researchers used molecular scissors called CRISPR / Cas9 to engineer immune cells that were then injected into a patient with lung cancer, Nature reports.

Researchers at Harvard T. H. Chan School of Public Health and the Broad Institute have identified the presence of this protein, called CD55, found to be critical to the Plasmodium falciparum parasite's ability to attach itself to the red blood cell surface during invasion.