Sentences with phrase «cell resolution in»

«In studying leukemias, we are excited about now having the ability to genotype multiple mutations at single - cell resolution in this level of high throughput.

-- To better understand how and why these specialized sub networks are created, researchers at the Max Planck Florida Institute for Neuroscience (MPFI) have combined electrophysiological and optical approaches to manipulate and monitor neuronal activity at single - cell resolution in intact, functional brain circuits.

Not exact matches

Acquiring high - definition images of every cancer cell found in a blood sample, making characterization at single - cell resolution possible.

«In clinical trials in patients treated with CAR - T cells,» the FDA reported, «69 % of patients had complete resolution of CRS within two weeks following one or two doses of Actemra.&raquIn clinical trials in patients treated with CAR - T cells,» the FDA reported, «69 % of patients had complete resolution of CRS within two weeks following one or two doses of Actemra.&raquin patients treated with CAR - T cells,» the FDA reported, «69 % of patients had complete resolution of CRS within two weeks following one or two doses of Actemra.»

Yet just such an unlikely resolution may be in hand for one of the most acrimonious conflicts of recent times: the debate over human embryonic stem cells....

«The new Park Nanoscience Center at SUNY Polytechnic Institute provides researchers with greater access to Park Systems» cutting - edge AFM nanoscopic tools, featuring reliable and repeatable high - resolution imaging of nanoscale cell structures in any environment without damage to the sample.»

«Visualizing atoms of perovskite crystals: Researchers conduct the first atomic resolution study of perovskites used in next generation solar cells.»

The field of live - cell imaging has expanded greatly in recent years, but still faces many challenges, such as how to improve spatial and temporal resolution as well as how to keep cells healthy for extended periods of time.

Then in 1990, after 15 years» work refining sample preparation and electron detection, Henderson succeeded in using an electron microscope to create an image of a large bacterial cell membrane protein called bacteriorhodopsin, and do it at atomic resolution.

To test that idea in the ragworm, Tomer used a technique he had developed to examine the complex brains of small creatures with unprecedented clarity: He created a high - resolution map of the worm's brain cells according to the genes they express, not just their shape and location.

Earlier, for his Ph.D., he used his physics training to study biological interactions at the molecular resolution — but for his postdoc he changed approaches dramatically, turning to cell biology and applying his skills to the development of high - resolution functional imaging of DNA transcription in living cells.

A. Bartesaghi et al. 2.2 Å resolution cryo - EM structure of β - galactosidase in complex with a cell - permeant inhibitor.

A team from the Spanish National Cancer Research Centre (CNIO) has determined for the first time the high - resolution structure of a complex (R2TP) involved in key processes for cell survival and in diseases such as cancer.

«So using this method we can look at interactions between four biological components inside a cell in three - dimension and at very high resolution of about 10 nanometers,» Xu said.

«Young students of cognitive neuroscience are lucky to be in the midst of a new era where we have access to amazing new tools of science for eavesdropping on the population of cells with a superb temporal resolution,» Parvizi says.

Although both methods find great use in clinical application, they do not have sufficient spatial resolution to visualize glucose uptake down to single cells.

In their new study, they adapted DNA - PAINT technology to microscopes that are widespread among cell biology laboratories, called confocal microscopes, and that are used by researchers to image whole cells and thicker tissues at lower resolution.

This method has already been used successfully to reach a maximum resolution in the imaging of cells.

The team led by Professor Bozec turned off the oxygen sensor HIF in B cells and observed that this prevented the resolution of inflammation, leading to chronic inflammatory diseases.

To determine the most common type of age - related segregation errors, the researchers first used a novel high resolution imaging technique to visualize chromosomes in live mouse egg cells throughout the whole first stage of meiosis.

At lower levels, in the retina and in the geniculate, cells in these two subdivisions differ in their color selectivity, contrast sensitivity, temporal properties, and spatial resolution.

The change in vibration energy can be pinpointed by Raman mapping with a resolution of 300 nanometers, he said, allowing characterization of the activity of a single cell.

«So we've never been able to image the cells in high resolution as they produce this all - important biological material inside living plants.»

His work involves high - resolution imaging of chick embryonic tissue slices to study the cell - biological mechanisms driving neurogenesis in the spinal cord, for which Dr. Das played an instrumental role in pioneering new imaging technology.

A high - resolution map of the human cell has been generated — part of the Human Protein Atlas database — that provides the in situ localization of 12,036 human proteins at a single - cell level, covering 30 subcellular structures, and enabling 14 major organelle proteomes to be defined.

After this initial color assignment, the color information was propagated in time using the tracking information, thus providing a color - coded single - cell resolution fate map.

MIT engineers have now developed a way to visualize these molecules in higher resolution than previously possible in intact tissues, allowing researchers to precisely map the location of RNA throughout cells.

While working on his Ph.D., Dr. Taraska investigated the processes of triggered exocytosis and endocytosis in neuroendocrine cells with high - resolution microscopy methods.

«We have been able to view cell biology at high resolution on a microscope slide for a long time,» said Shroff, «but many times that's not how those cells exist in nature.»

Our side by side analysis uncovers the dynamics of epigenetic programming occurring in germ cell development at single base resolution in human and mouse cells.»

However, resolution of inflammation is associated with an elevation in the number of these cells.

According to Simon Rauber, an immunologist in Erlangen and primary author of the study, a previously inadequately studied cell population of the immune system called innate lymphoid cells plays a major role in the resolution of inflammations.

It's just not powerful enough — the resolution and sensitivity needs to be higher and the contrast needs to be greater in order to distinguish one type of cell from another,» says Zhang.

Professor Knight added: «Super resolution microscopy is a major step forward and we are looking forward to using this technology in a wide range of applications from stem cell behaviour to understanding arthritis or the development of nanomedicine.»

«Looking at a fixed cell at high resolution can tell you where different parts of the cell are at any given moment; but because much of biology depends on the movement of very small proteins finding each other and interacting, we really needed to look at how things move in a live cell.»

The significance of the team's approach is that it «enables imaging of live cells in a high - throughput manner at a time resolution at which all biologically relevant dynamics appear static,» he said.

The Bessel beam technique, however, is not the only game in town for 3 - D movies of cells, and it is not the highest resolution.

What's more, the resolution — the highest so far in these types of studies — was good enough to discriminate structures as small as individual cells.

«If something in the cell is moving at a micron a second and I have one micron resolution, I can take that image in a second.

Current techniques for observing the cytoskeleton can be difficult to get into living cells, can be toxic, and are usually limited in resolution and duration, since the signal wears off over time.

Invaluable as markers for monitoring photosynthesis and other energy - related processes in living cells, green fluorescent proteins (GFPs), discovered in a species of jellyfish, are vital in extremely high - resolution imaging studies.

In studying the functional behavior of the brain, from control of muscles to the formation of memories, scientists are using such tools such as electron microscopy, recordings of electrical signals from individual brain cells, and imaging of brain structures and processes using functional magnetic resonance imaging (fMRI), positron emission tomography (PET), and high - resolution optical imaging.

«The advanced nano - focussed x-ray beam at ESRF has not only allowed us to locate the site of action of our novel Organo - Osmium FY26 candidate drug in cancer cells at unprecedented resolution, but also study the movement of natural metals such as zinc and calcium in cells.

Called individual nucleotide resolution crosslinking immunoprecipitation (iCLIP), the technique enabled Sanford's lab to identify IGF2BP3 binding sites in several hundred RNA transcripts in two B - ALL cell lines.

The researchers used a 2 - photon photolysis technique that can be performed in vivo, together with imaging, to manipulate and monitor neuronal activity at single - cell resolution.

An interdisciplinary cooperation of biologists and physicists including Heidelberg researcher Prof. Dr Ulrich Schwarz now succeeded in performing high - resolution measurements of cell forces using light to switch them on and off in a controlled manner.

Here, we exploited microfluidics to control the metabolism of liver cells down to a resolution of a few cells, allowing us to create liver tissue that shows the same patterns of toxicity caused by differences in drug metabolism as the liver in your body.»

The speed, noninvasiveness, and high spatial resolution of this approach make it a promising tool for in vivo 3D imaging of fast dynamic processes in cells and embryos, as shown here in five surrounding examples.

Then they analyzed all the cells in the early embryos at single - cell resolution to see how effectively the mutation was repaired.

Scientists from the Leibniz - Institut für Molekulare Pharmakologie (FMP) in Berlin have now for the first time visualised the protein in healthy cells with the help of high resolution spectroscopic procedures.