Sentences with phrase «cell response at»

«SynNotch receptors essentially allow us to confine the T cell response at the site of disease with the goal of enhancing the ability of the T cell to, for example, overcome the inhospitable microenvironment of a solid tumor.

Not exact matches

No observed local immunological response at cell level after five years of oats in adult coeliac disease.

Some researchers have even looked at the chromosomes of the miscarried pregnancy to determine whether the NK cells were elevated because of the body's natural response to a chromosomally abnormal pregnancy.

Researchers at the European Union Reference Laboratory for alternatives to animal testing developed five different tests that use human blood cells to detect contaminants in drugs that cause a potentially dangerous fever response.

An immune response, triggered by foreign neural stem cells, could actually help attack tumors, says Evan Snyder, a stem cell biologist at Sanford Burnham Prebys Medical Discovery Institute in San Diego, California, and one of the early pioneers of the idea of using stem cells to attack tumors.

«This phase III trial will be noteworthy for being the first prostate cancer trial to assess a biomarker, namely AR - V7 in circulating tumour cells, as a predictor of response at the same time as testing the efficacy of the drug,» Prof Taplin will conclude.

Baier looked at the genetic mutations in the «frozen» fish and found one in the glucocorticoid receptor, a protein that is found in almost every cell and that senses cortisol — a hormone involved in the stress response.

«We're interrogating the tumor microenvironment,» she says, «by looking at suppressive cues as well as cells and secreted proteins that protect tumors from the immune response.»

We're pretty good at taking cells in isolation and being able to understand, at least in part, their response to injury.

The cells rose from the bottom of the dish in response to the magnet and clumped together at the interface between the gel and the air.

While investigating mouse eye cells, Botond Roska and his team at the Friedrich Miescher Institute for Biomedical Research in Basel, Switzerland, noticed that one type behaved unusually in response to movement.

«As you look for methods to discern complex immune responses in human cells, more and more people look at what genes are turned on with infections or vaccination procedures.»

When added to the cultured cells at molar ratios 103 to 104 times that of the luteinizing hormone releasing factor, both analogs decrease the amount of luteinizing hormone secreted in response to the releasing factor.

Based on these ex vivo experiments (in cells isolated from patients and then exposed to PD - L1 blocking agents outside of the body), they predict that when actual patients are given PD - L1 blocking agents, their viral load at the time will influence the «net» outcome, i.e., whether the blockage boosts or weakens the overall anti-HIV immune response.

Led by researchers at the Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James), the retrospective study suggested that a pattern of molecules called microRNA (miRNA) in tumor cells might predict patients» response to radiation therapy.

Julian Dindas, a PhD student at Hedrich's department, used microelectrodes that register the electric voltage of the root hair's cell membrane, the so - called membrane potential, to study the early responses of the cell to a hormone pulse.

Christof Koch, a neuroscientist at Caltech, and Itzhak Fried, a neurosurgeon at the University of California at Los Angeles, revealed this spring that their research team had discovered individual brain cells that fire in response to particular people and places.

The team found that brown fat cells express the ERRγ gene all the time (not just in response to cold) and that white fat cells do not express the gene at all.

A long - standing question has been how to improve the success of BMT by reducing GVHD incidence while, at the same time, preserving the anti-tumor response of donor cells.

The release of several signals by skin cells that are dying contributes to the creation and spreading of the chronic immune response and hyper - proliferation and irregular differentiation of epidermis,» says Joan Manils, first author of the study and member of the mentioned department and post-doctorate researcher at the Trinity Biomedical Sciences Institute (Ireland).

Analyzing immune cells in umbilical cord blood from 1074 infants, Zhang and colleagues found that babies who showed hyperactive innate immune responses at birth went on to develop a food allergy when tested at age one.

Building on the newly - published pilot study, the team will conduct experiments using a windtunnel which measures the behaviour of mosquitoes towards odours and electrodes which track the response of individual odour - detecting cells from within the antenna of the mosquito in specially - designed secure laboratories at the School to measure the responses of malaria - infected Anopheles gambiae s.s. females to human odours.

First author Kim Martinod, a graduate student in the Immunology Graduate Program at the Harvard University Medical School, found that, in response to vein constriction, these «rescued» mice now could function normally, forming clots as efficiently as mice with a functioning Pad4 gene, demonstrating that the Pad4 gene did produce a functioning PAD4 enzyme in these white blood cells to regulate blood clotting.

«Dendritic cells are essential for prompting the immune response against malignant cells and for driving the clinical success of cancer immunotherapy, but their function is often defective in cancer patients,» said Dmitry I. Gabrilovich, M.D., Ph.D., Christopher M. Davis Professor and program leader of the Immunology, Microenvironment & Metastasis Program at Wistar.

To figure out what's really happening within an organism — or within a particular organ or cell — researchers are linking the genome with large - scale data about the output of those genes at specific times, in specific places, in response to specific environmental pressures.

University of Alabama at Birmingham researchers have now shown that activated T - cells — part of the immune system's inflammatory response — are both necessary and sufficient to produce such heart failure.

«Our study suggests that although you need to have some level of IgE to trigger a food allergy response, you also have to produce MMC9 cells to get a severe response and anaphylaxis,» says Yui - Hsi Wang, PhD, lead investigator and a researcher in the Division of Allergy and Immunology at Cincinnati Children's.

First author Adam Skibinski, M.D. / Ph.D., student at Tufts University School of Medicine and the Sackler School of Graduate Biomedical Sciences at Tufts University, said «We've known for a long time that breast cells can lose their normal identity when they become cancerous, but we are now realizing that normal cells can change their characteristics as well in response to transcription factors like TAZ.

At the University of Calgary's Diabetes Research Centre in Alberta, immunologist Pere Santamaria is focusing on what he calls «weak» T regs, cells that seem to have only a very feeble antigen response.

Tumor cells use the unfolded protein response to alter circadian rhythm, which contributes to more tumor growth, Hollings Cancer Center researchers at the Medical University of South Carolina (MUSC) find.

They compared the immune response to rhinovirus when cells were incubated at 37 degrees Celsius, or core body temperature, and at the cooler 33 degrees Celsius.

This cell only responded to higher frequencies, especially at low volume levels; increased volume expanded the cell's frequency range of response.

The team used an imaging technique that allowed them to view the responses of over 100 Kenyon cells at a time and, importantly, quantify their results.

«The virus evokes a response in the infected cell that activates a pre-programmed cell death pathway,» said Stanley Lemon, M.D., one of the study's authors and a professor of medicine at UNC's School of Medicine and UNC's Institute for Global Health & Infectious Diseases.

Yet, investigators at the University of North Carolina at Chapel Hill have discovered that it is an immediate, intrinsic response of the HAV - infected cell that results in liver inflammation.

Partnering with the U.S. Food and Drug Administration allowed Doebele and colleagues to access clinical trial data describing initial tumor response, PFS and OS for 305 patients with stage IIIb or IV non-small cell lung cancer on trials of ALK inhibitors and 355 similar patients on trials of immunotherapies directed at PD - 1.

The researchers found that the gene expression levels in immune cells changed in response to the macaque's new social rank within 3 months of establishing the new groups, and the cells got better at fighting infection.

We describe an experimental model system that definitively links surgery and the subsequent wound - healing response to the outgrowth of tumor cells at distant anatomical sites.

At that critical stage, brain cells begin developing in response (and in proportion) to the baby's first experience of the outside world.

But there's a catch: viruses and tumour cells can also exploit the UPR for their own ends, enabling them to grow at a faster rate and to thwart the body's immune response.

«Our results provide the first evidence that blood promotes T cell responses against the brain,» says first author Jae Kyu Ryu, PhD, a staff research scientist at the Gladstone Institutes.

In this case, the stumbling block is that the semiconductor materials in solar cells, such as silicon, become conductive and generate energy only in response to photons at certain energy levels.

«ILCs and T cells appear very different, but in the end, the way they control key responses is amazingly similar,» said Han - Yu Shih, Ph.D., a post-doctoral fellow at NIAMS and first author of the paper.

Gregory F. Sonnenberg, PhD, research associate in the Department of Medicine, Gastroenterology Division, and the Institute for Immunology at the Perelman School of Medicine, University of Pennsylvania, with postdoctoral researcher Matthew Hepworth, PhD, report in Nature that innate lymphoid cells (ILCs) directly limit the response by inflammatory T cells to commensal bacteria in the gut of mice.

«The idea basically is that a vaccine should induce antibodies T cells immune response, that would neutralise HIV in all of its forms,» explains Ulrich Fruth, vaccine development and evaluation team leader at the World Health Organisation, in Geneva, Switzerland.

Mathew Garnett, a cancer biologist at the Wellcome Trust Sanger Institute near Cambridge, UK, says that HeLa cells could prove useful for studying aspects of the biology of cervical tumors, such as their response to cancer drugs.

Interestingly, the outbreak strain grew at a normal pace in cultured human white blood cells, apparently by subverting the immune response to its benefit.

A research group from the Department of Biomedicine at the University and the University Children's Hospital of Basel now discovered that innate lymphoid cells become activated and induce specific T and B cell responses during inflammation.

An international research team headed by the rheumatologist Dr Andreas Ramming at Friedrich - Alexander - Universität Erlangen - Nürnberg (FAU) has now managed to identify an immune system cell type that can be used in a targeted attempt to control the inflammatory response in arthritis patients.

«Our study shows a whole new route, or bypass mechanism, for triggering the body's adaptive immune response to TB infection, a means by which infected dendritic cells cooperate with uninfected dendritic cells to activate T cells and respond to the infection,» says infectious disease specialist and study senior investigator Joel Ernst, MD, a professor at NYU Langone Medical Center.