Not exact matches
In addition, selective probiotics, like bifidobacterium, can increase IgA secretion (40) as
well as indirectly enhance T regulatory
cell activity (18), thereby promoting mucosal tolerance and preventing the allergic
response.
The introduction of infant formula to babies» diets changes the infants» gut microbiome, thus affecting the
response of the infant immune system to pathogens.47 - 51 A greater amount of natural - killer
cells, suggesting a more mature immune system, have been found in breastfed infants than in formula - fed infants.52 In addition, pH level in the stomach of breastfed children is
better for the promotion of the protein - lipid α - lactalbumin (termed HAMLET), which induces apoptosislike death in tumor
cells.51, 53
«Didn't seem to have a
good response to the question about his previous experience with our
cell line.
«We're interrogating the tumor microenvironment,» she says, «by looking at suppressive cues as
well as
cells and secreted proteins that protect tumors from the immune
response.»
Scientists could build chips containing
cells from patients with specific genetic mutations, which could predict drug
responses in specific populations, as
well as personalized chips that predict an individual's drug
response.
We're pretty
good at taking
cells in isolation and being able to understand, at least in part, their
response to injury.
With our human gut - on - a-chip, we can not only culture the normal gut microbiome for extended times, but we can also analyze contributions of pathogens, immune
cells, and vascular and lymphatic endothelium, as
well as model specific diseases to understand complex pathophysiological
responses of the intestinal tract.»
Essentially, he's looking for immune
cells with barcodes that proliferate in individuals with a
good response, as opposed to those in whom the vaccine is ineffective.
Oral immunotherapy for peanut allergy induces early, distinct changes in immune T -
cell populations that potentially may help researchers determine which people will respond
well to the therapy and which immune mechanisms are involved in the
response, a new study suggests.
By carefully controlling the composition of the droplets and the strength of the magnetic field, the forces applied by the droplet can be controlled, and the
response of the surrounding tissue reveals its mechanical characteristics as
well as the cues that
cells are exposed to as the tissue grows.
The team also compared the animals»
responses to the therapy's effects in laboratory
cell samples and found that in vitro studies did not predict how
well the viral therapy and immune
response would fight tumor
cells in vivo.
To
better understand how this abnormal distribution of B
cell types in people with uncontrolled HIV affected their immune
response to the virus, researchers compared HIV - specific antibodies derived from both TLM and RM B
cells.
Half of the patients that could be evaluated showed big increases in the numbers of T -
cells specifically reactive to tumor material, indicating a
good response to vaccination.
According to the researcher, further studies are warranted to confirm
responses in primary
cells and to reveal whether Rho - kinase inhibition stimuli can be used to manufacture a
better cartilage - type of tissue in laboratory.
She sees all these lines of research converging on the notion that a strong
cell - mediated
response gives people the
best chance of defeating HIV.
They found that NF - κB, a protein complex known to promote tumor growth, may also have the ability to boost the immune system to eliminate cancerous
cells before they harm, as
well as promote antitumor
responses.
In particular, they found significant expansion of CD3 + CD8 + cytotoxic T -
cells and CD3 + CD4 + helper T -
cells in circulating blood, as
well as increased CD4 + subsets of Th1, Th2, Th17 and Treg
cells, indicating a pro-inflammatory
response.
First author Adam Skibinski, M.D. / Ph.D., student at Tufts University School of Medicine and the Sackler School of Graduate Biomedical Sciences at Tufts University, said «We've known for a long time that breast
cells can lose their normal identity when they become cancerous, but we are now realizing that normal
cells can change their characteristics as
well in
response to transcription factors like TAZ.
JAK1 is part of a
well - studied regulatory network of proteins that is involved in the control of
cell growth, differentiation, apoptosis, inflammation, and immune
response.
To further validate AH10 - 7's effectiveness, the researchers tested the new compound in wild mice as
well as partially «humanized» mice, whose genomes were modified to mimic the human iNKT
cell response.
The vaccine generated a pool of TH1 CD4 + T
cells (also called helper T
cells) that are necessary for an effective antibody
response as
well as a stable pool of CD8 + T memory
cells.
The researchers found that the gene expression levels in immune
cells changed in
response to the macaque's new social rank within 3 months of establishing the new groups, and the
cells got
better at fighting infection.
This discovery lays the groundwork for a
better understanding of the role progenitor
cells can play in immune system
response and could lead to the development of more effective therapies for a wide range of diseases.
If electrical energy can be used to modulate
cell response, why not optical energy as
well, Boyden asks.
Researchers have successfully used human stem
cells to generate functional pituitary tissue that secretes hormones important for the body's stress
response as
well as for its growth and reproductive functions.
The protein GATA - 3 plays an important role in mammalian immune
response, but its overall function in
cell development and cancer formation is not
well understood.
«And this allows the
cells to regulate a vast number of genes, which then allows it to
better adapt and survive in
response to starvation and stress.»
Up until now, efforts in generating a vaccine against TB have been mainly focused on T
cells (
cells from the adaptive arm of our immune
response with memory capacity), with very disappointing outcomes in both pre-clinical as
well as clinical trials.
In future, it may be possible to measure BCR - ABL levels in individual
cells in the clinic — this will help us identify the resistant high BCR - ABL
cells and
better understand how patients develop resistance to imatinib treatment with the aim of combatting this resistance to make
response more durable and the treatment more effective.»
Gene therapy, which often employs viruses to deliver the
good genes to a body's target
cells, has been known to trigger severe immune
responses and was blamed for the death of an 18 - year - old in 1999, who was receiving gene therapy for a hereditary metabolic disorder.
However, researchers are still learning how
best to implement immunotherapy regimens, making monitoring of the immune
response during treatment development and implementation critical to predicting how the modified
cells will function, and how the immune system as a whole will react.
Although these developmental roles are
well documented it is less clear how competent these
cells are to respond to infection and whether they play a significant role in the immune
response of the embryo.
«In a perverted twist of fate, cancer
cells take advantage of this incredibly ancient survival strategy — the heat shock
response — to help them survive despite the
best efforts of our own natural defenses, and sophisticated therapeutics, to kill them,» says Whitehead Member Susan Lindquist.
By developing blood biomarkers and «immunologic signatures» related to antigen - specific T -
cell responses, the researchers hope to identify individuals with latent TB infection who are at greatest risk for progression to active disease, allowing development of prevention strategies to target those at highest risk in areas with high rates of infection (usually low - and middle - income countries), as
well as high income countries such as the U.S., where factors such as recent infection and HIV co-infection are associated with an increased risk of progression to active TB.
Evidence is growing that in some long - term infections, such as malaria, certain types, or combinations, of HLA molecules are
better at provoking strong
responses from T
cells.
«This study suggests that if your T -
cell response to the initial infection is
good, but not enough to clear the virus, then you may respond to PD - 1 blockade years later.
The new method, published today in the journal Nature Biotechnology, has implications for
better understanding how different groups of
cells change during disease progression, in
response to drug treatment, or across evolution.
This may be of particular importance in the ageing lung as pulmonary infections are the primary cause of morbidity and mortality in the elderly, as discussed by Boe et al. 11 Innate
cells appear to have reduced TLR signalling via MAPK and NFƙB resulting in reduced inflammatory cytokine production as
well as altered chemotaxis
responses, decreased phagocytosis and antigen presentation capacity.
In this context, we have studied the role of ERK7 in Drosophila S2
cells in
response to serum starvation, and have shown that amino - acid starvation leads to the formation of a of novel membrane-less stress assembly, the Sec bodies, as
well as stress granules.
«If our predictions hold true, tumor
cells with intact p53 may show the
best response to therapy targeting the IGF - 1R signal; however, when p53 is not functioning normally,
response to this therapy may not be as expected,» said Greenberg, the study's corresponding author.
The first neoadjuvant trial of interferon (UPCI 00 - 008) reveals its effects are immunological, and mediated through modulation of STAT3 and dendritic
cells, as
well as T
cell responses to melanoma.
He previously revealed the existence of spontaneous immune
responses in ovarian tumors as
well as described how regulatory T
cells and tumor blood vessels affect these
responses.
Specifically, TheraT ® has proven to be safe in animals as
well as capable of eliciting uniquely potent antigen - specific CD8 + cytotoxic T
cell responses and strong tumor control in mice.
In addition to p53, there are other transcriptional activatory mechanisms that are not
well understood for the most part and which operate in
response to mitogenic stimulation (11, 12), transforming growth factor - β (13, 14, 15), and aberrant oncogenic signals (16, 17) or during a number of
cell differentiation processes (18, 19).
Furthermore, assessment of the immune
response to transplanted iPSCs was favourable, while
cells transplanted at early time points had a
better ability to differentiate into mature neural
cells, perhaps due to the suppressive effects of the micro-environment at the transplant site at later timepoints.
Of special interest were ICOS, whose «role in effector T
cell responses and anti-tumor immune
responses is now
well established,» and CD40, which is «important for the maturation of antigen - presenting
cells and for enabling T
cell co-stimulation.»
An analysis of HIV vaccine trials (mostly ones that use DNA vaccines) showed that women showed
better T -
cell responses to such vaccines than men, and people with a lower body mass index showed
better T -
cell responses than people with a higher body mass index.
«My whole work is about immune
cell responses to melanoma — how we can teach particular immune
cells called killer T
cells to recognise melanoma
better, target melanoma
better and kill melanoma
better,» Katherine says.
In particular, glucose utilization and related unfolded protein
response as
well as autophagy were reported to become deranged in diverse cancer
cells [8, 72, 73].
Numerous studies have demonstrated activity of these agents against a wide variety of cancers, especially cancer stem
cell - like subpopulations, by a host of different mechanisms which comprise inhibition of signaling pathways, of mitochondrial respiration, as
well as of cellular stress
responses and others.