Sentences with phrase «cell response to chemotherapy»
Epigallocatechin -3-gallate (EGCG) found in green tea even acts as an antiangiogenic and antitumor agent, and helps modulate tumor cell response to chemotherapy.30
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The researchers found that, in response to the maximum tolerated doses of several commonly used chemotherapy drugs, breast cancer - associated fibroblasts secrete large amounts of cell signaling proteins called ELR + chemokines.
Cancer cells had essentially figured out how to survive by rewiring their metabolism in response to chemotherapy.
The aim of neoadjuvant chemotherapy is to eliminate active cancer cells — producing a complete response — before surgery.
«Blocking the damage response in normal cells that have been bathed in chemotherapy could be instrumental in keeping errant or dormant cancer cells from starting down the path to proliferation,» he said.
Findings based on this new technology are likely to have a profound impact on improving the detection and diagnosis of diseased cells and in evaluating a patient's response to chemotherapy.
Intermittent dosing with rapamycin selectively breaks the cascade of inflammatory events that follow cellular senescence, a phenomena in which cells cease to divide in response to DNA damaging agents, including many chemotherapies.
This blood vessel normalization results in an increased barrier function on the one hand — thereby blocking cancer cell dissemination and metastasis - and in enhanced tumor perfusion on the other hand, which increases the response of the tumor to chemotherapy.
Treatment with an investigational CAR T - cell therapy induced complete remission of a brain metastasis of the difficult - to - treat tumor diffuse large - B - cell lymphoma (DLBCL), which had become resistant to chemotherapy — the first report of a response to CAR T - cells in a central nervous system lymphoma.
The resulting «map» of gene - drug interactions allowed the researchers to accurately predict the responses of multiple human cancer cell lines to different chemotherapy agents based on the cell lines» genetic profiles and also revealed new genetic factors that appear to determine the response of breast and ovarian tumor cells to common classes of chemotherapy treatment.
«The work from Lynne Maquat's lab is critical because it demonstrates the role for NMD in cancer cell survival and shows us how the NDM pathway might be connected to chemotherapy response,» said Hartmut «Hucky» Land, Ph.D., director of research at the Wilmot Cancer Institute.
During the stress response that occurs as a cell becomes cancerous, and in response to chemotherapy, p53 attempts to repair DNA damage that has occurred, and, if not successful, p53 orders the cell to die.
Current projects in the laboratory include: 1) functional screens of ubiquitin ligases to identify novel cancer drug targets; 2) defining the molecular regulation of breast cancer metastasis to the brain; and 3) understanding signaling pathways that influence the response of cancer cells to chemotherapy.
Low - dose chemotherapy, radiation, or targeted therapies given in combination with immune checkpoint blockade may prove to be an effective and efficient way to immunize the body against tumor cells,» says CRI Scientific Advisory Council associate director James P. Allison, Ph.D., who identified the first immune checkpoint blockade with his discovery in 1995 that the cytotoxic T lymphocyte antigen - 4 (CTLA - 4) receptor inhibited T cell responses.
The vaccine encourages the body to create its own response to the «invasion» of the vaccine and stimulates the body's immune system, while traditional treatments, such as chemotherapy, kill white cells that defend the body and destroy infection.
Cancer cells don't have such a response, leaving them susceptible to the chemotherapy.
The poor response of mesothelioma treatment to chemotherapy is not well understood, but it is thought to be related to the way mesothelioma cells develop.