Sentences with phrase «cell responses because»

Not exact matches

Not surprisingly, President Obama received high marks from the journal, largely because his response to the question of whether he would lift Bush's ban on the federal funding of new embryonic stem - cell lines is in line with the view of most in the scientific community.

Some researchers have even looked at the chromosomes of the miscarried pregnancy to determine whether the NK cells were elevated because of the body's natural response to a chromosomally abnormal pregnancy.

That development is important because a T cell response will likely confer longer - term protection than current inoculations do and defend against a variety of flu strains (because T cells would be on the lookout for several different features of the flu virus whereas antibodies would be primarily focused on the shape of a specific strain).

But this process is important because «if the apoptotic cells are not properly cleared... it will affect the cell death activation» in organisms like worms and cause persistent inflammation and autoimmune responses in humans.

«While transient disruption of this pathway may have therapeutic benefit because it temporarily «revs up» the immune response, permanent loss of PD - 1 signals seems to result in a «flame out» where T cells can't sustain higher level activation and become more dysfunctional,» Wherry says.

Using cells from cadavers, doctors have been experimentally transplanting pancreatic islets into humans for decades, but as many as 60 percent of the transplanted islets die immediately because they are cut off from their blood supply and are killed by an immune response due to direct injection into the bloodstream, and those that survive the transplant usually die within several months.

This is because memory B cells, which remember antigens in the primary immune response, are induced and respond faster in the secondary exposure to bacteria or viruses and differentiate into antibody - producing cells.

«Because of the important role of UPR in regulating cell life / death decisions, it is critical that mechanisms are in place to prevent unnecessary UPR activation in response to innocuous or low - level stimuli,» said Wilkinson.

The finding was surprising because previous research had highlighted a likely role for white blood cells known as CD8 + and CD4 + memory T cells for broadening the immune response against different flu strains.

They have evidence that some people may be able to resist infection because previous exposure to tiny amounts of virus has stimulated a strong response from killer T cells which can destroy cells infected with virus.

The finding that immune cells in the skin, especially skin showing an autoimmune response, mediate the strongest anti-tumor response is surprising because T cells are traditionally thought to reside in immune organs, such as lymph nodes, spleen, and blood.

The researchers hypothesize that guanabenz stimulates a protective cascade — because fewer oligodendrocytes die, less immune cells are recruited to the brain, which results in a decreased inflammatory response and preservation of myelin levels.

She ultimately chose to study leukemia patients» immune responses to bone marrow transplants, an area conducive to translational research in part because the work involves treating patients with human cells, which can be prepared at academic health centers.

The team, led by Stephen Liberles, Harvard Medical School associate professor of cell biology, has effectively deconstructed the vagus nerve, a key connection between body and brain that is important because it controls not only breathing but also heart rate, feeding behavior and responses to illness.

Because these islets carried the kind of peptide that spleen cells use to reeducate the immune system, they were able both to control blood sugar and to end the autoimmune response.

Because CD4 + (helper) T cell responses have been shown to be sufficient for protection from WNV challenge (independent of B cells and CD8 + T cells) and crucial for viral clearance from the CNS, the researchers focused on the WNV - specific CD4 + T cell repertoires present in the blood samples.

According to the researcher Rosalva Rangel Corona, head of the project, the antitumor effect of interleukin in cervical cancer is because their cells express receptors for interleukin - 2 that «fit together» like puzzle pieces with the protein to activate an antitumor response.

The researchers concluded that in the early stages after stroke, improvements in voluntary movement can be attributed to a reduction in brain swelling because of the trauma and other spontaneous repairs, while later improvements result from «neuronal plasticity» — the reorganization or regeneration of nerve cells within the spinal cord in response to changes in the nerve network.

The only blood components that contain DNA are white blood cells, but blood banks routinely irradiate donor pints with gamma rays to kill off these cells because they can trigger a rejection response in their new host.

But this pathway can't be the only one that triggers thermogenesis, because mice lacking PGC - 1α in their fat cells, or ERRα, still show most of the usual thermogenesis response to cold.

The animals had no detectable immune response against the eCD4 - Ig, presumably because it is so similar to pieces of their own cells.

What the microglia do between crises has been unclear, largely because getting the cells under a microscope has required excising a chunk of brain tissue — thereby causing damage that sends the cells into emergency response mode.

The scientists specifically examined proteins on the surface of the naive CD4 + T cells because these proteins play an important role in the cell development and mediate the corresponding responses to stimuli from the environment.

«The work from Lynne Maquat's lab is critical because it demonstrates the role for NMD in cancer cell survival and shows us how the NDM pathway might be connected to chemotherapy response,» said Hartmut «Hucky» Land, Ph.D., director of research at the Wilmot Cancer Institute.

Each point represents one individual donor and is averaged from 25 — 75 sequences, except for the primary response to anthrax from which only 10 VH genes could be cloned from single cells because of the highly limited response.

4 The downstream signaling pathways of some growth factor receptors was also intact because many of the cell lines exhibited proliferative responses to certain of the known endothelial cell mitogens.

This is of interest because a cell's genetic material is housed in the nucleus, and this is the location where different genes get turned on and off in response to external stimuli, such as the presence of lipids from fatty foods.

We chose this model because 1) it more closely recapitulates features of human pancreatic cancer than do s.c. - implanted tumors, 2) it can be used in immunocompetent mice to permit assessment of immune responses, and 3) the cells grow in vivo with predictable kinetics (34).

The first is that typically we don't know how actively to treat glaucoma, even in patients with very elevated pressures, because people vary in the extent to which they lose ganglion cells in response to pressure increases.

Until now, however, achieving a similar feat in human cells has eluded scientists — partly because activating iNKT cells released different types of cytokines: some stimulated an immune response, while others inhibited it.

Conceptually, the antigen - specific enhancement of Treg cell function is of particular importance because such strategies will minimize the requirements for pharmaceutical immunosuppression, sparing desired protective host immune responses to infectious and malignant insults.

Quantitative analysis of sensory response is very difficult, however, because it involves a synthesis of the action of many cells.

Because higher GLP - 1 responses are associated with better insulin secretion, the low incretin levels could partly explain the reduction of β - cell function observed in women when becoming IGM or T2DM.

Because our current understanding suggests these molecules control many functional activities of T cells, and the effects might vary depending on the subset of T cell, they are therefore potential targets for either suppressing an immune response, or for promoting an immune response.

Because the drug's mode of action was known and patients» response to treatment could be precisely monitored, Michor and colleagues used modeling methods and data from patients in a large clinical trial to identify a group of copiously self - renewing stem cells, which persist within the tumor, resist the drug, and sustain the cancer.

Our underlying premise is that the tumor microenvironment is immune suppressive because cancer cells elicit responses characteristic of wound healing and tissue regeneration.

Live cell assays constructed with genetically encoded, fluorescent biosensors can provide significant advantages over endpoint assays measured in cell lysates because functional information about the timing and location of cellular responses can be monitored in cells that are relevant to disease.

Because GVHD is primarily a result of a naive T cell response (50), treating GVHD with VPA may offer a great advantage.

Because the body's immune response takes three weeks to kick in, cells capable of killing bacteria arrive too late to finish off the organism.

Because the same pool of naïve T cells can differentiate into inflammatory effector T cells or inhibitory Tregs, generation of immune responses requires promoting the differentiation of inflammatory T cells while reciprocally inhibiting the formation of Tregs.

Because cells in the brain are constantly transferring information and triggering responses, there are dozens of areas of the brain at least peripherally involved in fear.

We believe DCs are the most important immune cells to target because they initiate the specific immune response that generates CTLs to kill the tumor.

Because Syk is expressed in many kinds of hematopoietic lineage cells and involved in various ITAM - mediated signal transduction pathways (45), our current finding that RhoH facilitates Syk activation will shed new light on ITAM - based immune responses.

If someone has an immune response to wheat, but it does not result in celiac, they will manifest that in other ways, such as becoming Type 1 diabetic because the immune response has killed the islet cells, or their thyroid becomes inactive or cancerous... or their spleen swells up, or they manifest arthritis or rheumatic illness of some kind....

Since ashwagandha is a member of the solanacea family, individuals with an auto - immune response may experience extraordinary results if they are TH - 1 dominant, but it could exacerbate their condition if they are TH - 2 dominant because of its effect in stimulating natural killer cells.

70 % -80 % of your immune response occurs in your gut, because that's where antibiotics attack most germs and it's where the majority of your immune cells go to fight off germs when you're sick.

In this paradigm, specific foods are fattening because they induce metabolic and hormonal responses in the body — in the periphery, as its known in the lingo — that in turn induce fat cells to accumulate fat.

Even obesity can be characterized as an inflammation response, because the fat cells help to produce the pro inflammatory cytokines (proteins) that stimulate the inflammatory response.

I have a question: my raw food facebook group discourages eating fat and sweet food at the same time saying that the fat (in this case it could be flaxseeds) messes up the metabolism of the sweet foods, and provokes a higher insulin response because the sugar of fruit for example can not get to the cells and remains in the bloodstream longer — > more insulin.

Because of these links between fat cells and the immune response, scientists at Chosun University in Gwangju, South Korea, and other institutions recently began to consider whether exercise might affect the body's response to germs.