Sentences with phrase «cell responses between»

RESULTS: A significant difference in the quality of the T - cell responses between patients in Study 201 and those in earlier studies of AN1792 was noted.

To understand the potential basis for this differential efficacy, we are comparing epitope repertoires and exploring the molecular basis for differences in T cell responses between aP - and wP - primed individuals.

Not exact matches

Referring to Plato's depiction of a «world soul» in the Timaeus, Hartshorne posits that just as people have a mutual relationship of response and reaction between the cells of their body and themselves, there is a similar mutual relationship of feeling between God and cell - like elements within the world: atoms, cells, people.

Q: Is there some connection to be made between the responses of cells encountering stress or injury versus a whole person?

The research, published and featured in the Spot Light section of the December edition of the Journal of Virology, examines a previously unknown connection between flaviviruses — a classification of viruses that include West Nile virus, Dengue virus and tick - borne encephalitis virus — and organelles (a specialized subunit within a cell) known as peroxisomes that help coordinate the body's immune responses.

The cells rose from the bottom of the dish in response to the magnet and clumped together at the interface between the gel and the air.

Primarily, ATP functions as the energy currency of cells but, in some varieties, a tiny amount is secreted into the space between cells, where it latches onto a neighbor to induce particular responses and modulations.

Without the regulatory influence of PD - 1, the over activated and over stimulated T cells result in disruption of a crucial balance between different T cell types that leads to an overall greatly reduced immune response.

She also sought out genes that controlled the switch for maturation of T helper cells, maintaining just the right balance of T helpers — between Th1 cells that suppress allergic responses and Th2 cells that trigger them.

He cautions there is a huge gap between the simple response of single - celled animals and the cognitive abilities of developed species, but adds there is no doubt that a combined set of simple circuit models will have more complex behaviour.

«We've shown that a specific type of these cells, known as follicular helper T (Tfh) cells are not only necessary, but are a limiting factor that differentiates between an average and a potent antibody response to HIV,» says Crotty, a scientific collaborator with the Center for HIV / AIDS Vaccine Immunology & Immunogen Discovery (CHAVI - ID), a major research consortium led by The Scripps Research Institute.

Further, the study showed a direct correlation between levels of Tfh cells and antibody response.

To investigate the relationship between temperature and immune response, Iwasaki and an interdisciplinary team of Yale researchers spearheaded by Ellen Foxman, a postdoctoral fellow in Iwasaki's lab, examined the cells taken from the airways of mice.

... We essentially start with those cell lines, try to identify patterns between the mutational status of the cell line and the response to a particular drug, either in terms of the ability of the drug to inhibit a pathway.

While Dillin discovered the ability of mitochondria to communicate between different cells and tissues several years ago, the new study pinpoints serotonin as a primary driver of this metabolic response, he said.

Cincinnati Cancer Center (CCC) and UC Cancer Institute researchers have found that a vaccine, targeting tumors that produce a certain protein and receptor responsible for communication between cells and the body's immune system, could initiate the immune response to fight cancer.

There is a lot known about how plant and animal cells respond to extreme heat stress, but not much was known about their response to ambient heat or how they regulate their response to heat between day and night.»

The team, led by Stephen Liberles, Harvard Medical School associate professor of cell biology, has effectively deconstructed the vagus nerve, a key connection between body and brain that is important because it controls not only breathing but also heart rate, feeding behavior and responses to illness.

Moreover, the gene expression responses in CD4 + T cells stimulated with WNV differed between individuals with previous asymptomatic infection and those who had neuro - invasive WNV disease.

The synapses between cells are awash in hormones and neurotransmitters that modulate the transmission of signals, and the synapses constantly form and dissolve, weaken and strengthen in response to new experiences.

The research team suggests that this normal contact between the two cell types is exploited by cancer cells, in which contact - based, mutually reinforcing cross-talk between them turns off the immune response.

This included detailed comparisons between immune T cell responses in the lungs, spleen and blood.

Now, the Martin team has found a subset of cells, squeezed in between the main LGN layers in marmoset monkeys that fire in response to inputs from both eyes.

The results show that generation of an optimal immune response to cancer requires cooperation between two types of memory T cell — one circulating in the blood and the other resident in tissues — that can be reactivated with current immunotherapy strategies.

They hypothesize that the reactive particles may induce an immune response in the body or modify the biochemical signaling agents between cells.

What the microglia do between crises has been unclear, largely because getting the cells under a microscope has required excising a chunk of brain tissue — thereby causing damage that sends the cells into emergency response mode.

«Bowhead whales weigh between 50 and 100 tons when fully grown and have probably 1,000 times as many cells as humans, but they apparently have a anti-tumor response at the cell level that is far more efficient than what is found in humans,» said biologist Mads Peter Heide - Jørgensen of the Greenland Institute of Natural Resources and the University of Copenhagen.

Whole taste nerve recordings in WT mice show that 5 - HT3 antagonists (both ODS and pentobarbital) significantly decrease responses to most tastants, suggesting that 5 - HT3 receptors have a role in communication between taste receptor cells and afferent nerve fibers.

But of course, posed this way the question does not distinguish between stem cells obtained in different ways (and indeed it is sensible to assume that those who expressed opposition in response to this question believed they were being asked about embryonic stem cells, although the survey does not allow us to know that with confidence).

Hypothesis driven approaches to vaccinology can utilise the knowledge gained from mechanistic mouse models and our molecular understanding of intrinsic defects to human cells.5 However, caution is required when extrapolating data from murine models, as there are substantial differences between immune ageing in mice and humans.6 Nevertheless, model systems and ex vivo analyses of molecular alterations in aged human cells have identified multiple changes in the vaccination response with age and the aged immune system in general.

By showing that ligands associated with innate immunity enable dendritic cells to initiate T cell responses, this work provided the key missing link between the innate and adaptive immune responses.

iNKT - cell help to B cells: A cooperative job between innate and adaptive immune responses.

The establishment of a T cell response requires a direct interaction between T cells and antigen presenting cells (APC).

We will combine methods from the fields of immunology, developmental biology and angiogenesis to understand in vivo the development and lineage - specific function (s) of resident macrophages, thereby opening new venues of research into the interaction between macrophages and endothelial cells in response to tissue damage.

Veto - like activity of mesenchymal stem cells: functional discrimination between cellular responses to alloantigens and recall antigens.

High - dose interleukin - 2 for the treatment of metastatic renal cell carcinoma: a retrospective analysis of response and survival in patients treated in the surgery branch at the National Cancer Institute between 1986 and 2006.

Discovered in the late 1970s, the mechanism, called the unfolded protein response, relies on communication between the ER and the cell nucleus: When misfolded proteins, which can cause stress - related diseases, accumulate in the ER, cells counter the surge by triggering a program of gene expression in the nucleus that raises the abundance of ER proteins that foster protein folding and activates a mechanism that degrades protein clumps.

For the first time immune cells created from human induced pluripotent stem cells (HiPSCs) have been used to model immune response variation between people

Chief among them was the finding that in all placental mammals FOXP3 acts through a snippet of DNA called the CNS1 enhancer to trigger the formation of a cohort of Tregs designated «peripheral» (whereas most Tregs are produced in the thymus gland, which sits between the lungs, a subset of the cells act as sentinels suppressing runaway immune responses in the body's peripheral tissues).

«Depending upon molecular fluctuations, a single gene in a cell may switch randomly between active and inactive states, leading to vastly different biological responses, even for genetically identical cells,» says Munsky.

No Association Between Response Rates and Survival in Newly Diagnosed Multiple Myeloma: Results of a recent meta - regression analysis of 63 randomized clinical trials out of Greece concluded that there was no association between conventional response outcomes, such as complete response (CR) or very good partial response (VGPR), and overall (OS) or progression - free survival (PFS) in patients with newly diagnosed multiple myeloma in populations of patients who received stem cell transplant and those who dBetween Response Rates and Survival in Newly Diagnosed Multiple Myeloma: Results of a recent meta - regression analysis of 63 randomized clinical trials out of Greece concluded that there was no association between conventional response outcomes, such as complete response (CR) or very good partial response (VGPR), and overall (OS) or progression - free survival (PFS) in patients with newly diagnosed multiple myeloma in populations of patients who received stem cell transplant and those who Response Rates and Survival in Newly Diagnosed Multiple Myeloma: Results of a recent meta - regression analysis of 63 randomized clinical trials out of Greece concluded that there was no association between conventional response outcomes, such as complete response (CR) or very good partial response (VGPR), and overall (OS) or progression - free survival (PFS) in patients with newly diagnosed multiple myeloma in populations of patients who received stem cell transplant and those who dbetween conventional response outcomes, such as complete response (CR) or very good partial response (VGPR), and overall (OS) or progression - free survival (PFS) in patients with newly diagnosed multiple myeloma in populations of patients who received stem cell transplant and those who response outcomes, such as complete response (CR) or very good partial response (VGPR), and overall (OS) or progression - free survival (PFS) in patients with newly diagnosed multiple myeloma in populations of patients who received stem cell transplant and those who response (CR) or very good partial response (VGPR), and overall (OS) or progression - free survival (PFS) in patients with newly diagnosed multiple myeloma in populations of patients who received stem cell transplant and those who response (VGPR), and overall (OS) or progression - free survival (PFS) in patients with newly diagnosed multiple myeloma in populations of patients who received stem cell transplant and those who did not.

My current projects focus on understanding the molecular mechanisms of the balance between protective and pathogenic T cell responses to flaviviruses, including Dengue and Zika.

Schulten V, Tripple V, Sidney J, Greenbaum J, Frazier A, Alam R, Broide D, Peters B, Sette A. Association between specific timothy grass antigens and changes in TH1 - and TH2 - cell responses following specific immunotherapy.

We are currently investigating the role of various T - cell costimulatory pathways in regulating the humoral and cellular responses to and between DENV and ZIKV, and are defining the particular pathways that should be targeted to maximize safety and efficacy of vaccines.

Insofar as kinase inhibitors interfere with signaling dynamics, and, in turn, signaling dynamics affects inhibitor responses, we investigated associations in this study between cell - specific dynamic signaling pathways and drug sensitivity.

No associations were found between CRP and pre-transplant response, bone marrow plasma cell percentage, or labeling index.

The crosstalk between tumor cells and the tumor microenvironment and how it orchestrates tumor progression and response to therapy

This clustering enables the cells to communicate with one another, but also makes it difficult for scientists to distinguish between a given cell's direct response and one indirectly caused by a message from a neighboring cell.

Cortisol, a hormone, and one of the main stress response chemicals produced by the adrenal glands — the other is adrenaline — is responsible for maintaining the health of and proper communication between every cell in your body.

These can cause damage to the lining of gut or the tight links between the cell wall, letting proteins and bits of bacteria into the bloodstream, setting off an inflammatory response throughout the body.