Sentences with phrase «cell responses following»

Schulten V, Tripple V, Sidney J, Greenbaum J, Frazier A, Alam R, Broide D, Peters B, Sette A. Association between specific timothy grass antigens and changes in TH1 - and TH2 - cell responses following specific immunotherapy.

Identification of optimal vaccine formulations and administration routes for the induction of CD8 + T - cell responses (SSI): The induction of suitable CD8 + T - cell responses following vaccination usually requires the use of live viral vectors.

Not exact matches

Inflammation in response to the Salmonella stressed the pathogens themselves, and the resulting damage promoted bacteriophage replication, followed by rupture of the bacterial cell wall and release of the bacteriophages.

They found that STAT6 - IP prevented RSV - induced changes to airway cells called alveolar macrophages, which can promote asthma - like responses both during and following viral infections.

Intermittent dosing with rapamycin selectively breaks the cascade of inflammatory events that follow cellular senescence, a phenomena in which cells cease to divide in response to DNA damaging agents, including many chemotherapies.

After a median follow - up of 11 months, 11 of the 13 patients who responded remain on the study, including one patient who had non-small cell lung cancer (NSCLC) with a ROS1 gene fusion who has had a complete response that has been maintained for more than two years.

The system is based on the Appendicitis Inflammatory Response (AIR) score, which includes the following parameters: pain in right iliac fossa, history of vomiting, rebound tenderness or muscular guarding, body temperature, white blood cell count, proportion of neutrophil granulocytes, and C - reactive protein concentration.

They found substantial differences following influenza vaccination in the production of immune - modulators that determine the type of T - cell response and in the proliferation and production of antibodies by B cells.

Importantly, Zika virus also follows the same pattern of cellular behavior of repressing the cell's translation and stress response while promoting its own protein translation.

The vaccine is unique to the individual participant and is engineered to trigger an immune system response to kill tumor cells that may remain following surgery.

In collaboration with the Broad Institute of Harvard and MIT, Sorger and colleagues leveraged an approach developed as part of the National Institutes of Health's Library of Integrated Network - Based Cellular Signatures (LINCS), a large - scale program that aims to amass molecular data from cells following drug exposure to study the mechanisms of drug response.

T - cells are crucial to the body's immune response to cancer, both endogenously and following therapeutic intervention.

Sepsis, Drs. Tracey and Deutschman wrote, «is not a stereotypical, steadily progressive immunological process that follows infection or injury; that innate and adaptive immune responses do not inevitably damage host cells; and that the long - held notion that sepsis is a distinct immunological disorder is incorrect.

For the other experiments, recombinant HA (His - tagged) was immobilized at 5 µl / min − 1 on NTA sensor chips with a target density of 350 response units, and the antibodies at concentrations ranging from 1 to 30 nM in HBS - P buffer were injected at 20 µl / min − 1 over the immobilized recombinant HA or reference cell surface, followed by a 600s dissociation phase.

The protocol can be used to measure adaptive responses following the stimulation of whole blood samples or purified peripheral blood mononuclear cells (PBMCs) and includes a freezing step that allows the stimulated samples to be shipped from the collection site to the analysis facility.

We notably follow the time course of structural changes in response to cues that affect gene expression either transiently or permanently: changes in genome structure during transient hormonal response of differentiated cells and stable trans - differentiation of B cells to macrophages.

The HZI will develop a vaccination protocol for mucosal administration based on three novel strategies: (i) development and optimization of a vaccination protocol in which parenterally - primed T and B cells are subsequently pulled into the mucosa by the local delivery of the cognate antigen to the requested effector site, (ii) testing the co-administration of antigens with novel mucosal adjuvants using different mucosal immunisation routes and schedules, and (iii) testing various nanoparticles co-administered with different immunomodulators for their ability to generate both systemic and mucosal immune responses following transcutaneous / trans - follicular vaccination.

Investigating conventional MHC - restricted T cell responses specific for tumor - associated peptide antigens, and local immune contextures, in mediating cancer control in patients following neoadjuvant (per - surgery) therapy.

Researchers have illuminated a crucial step in the immune system's response to infection by using live cell imaging to follow the movement of immune system cells that have been genetically...

Historically, many vaccines have been designed to evoke an antibody response by B cells following innoculation with weakened or dead pathogens.

To determine the role of inflammatory response in the pathophysiology of these diseases, glial cell morphology and essential functions, such as glutamate transport, ion recapture and modulation of neurotransmission will be evaluated following infusion of autoantibodies in the hippocampus.

Retinoid - X-receptors (a / ß) in melanocytes modulate innate immune responses and differentially regulate cell survival following UV irradiation.

Moreover, the increase in leukocyte infiltration is most striking when considering the total numbers of CD4 and CD8 T cells, providing further evidence for a T cell - mediated immune response in the brain and / or meninges following infection with attenuated Type I parasites (Figure 3F).

These include T - cell depletion by apoptosis; anergy (ie, the process by which T cells that are presented with a peptide in the absence of costimulatory signals become refractory to further stimulation with the antigen and are therefore inactivated); and the development of regulatory T cells, which can actively suppress antigen - specific responses following re-challenge with the antigen.

Working with Dr. Weiskopf, we established a model of human dengue disease using HLA transgenic mouse strains, and characterized human dengue - specific CD8 + and CD4 + T - cell responses in natural infection as well as following vaccination.

The latter work addresses questions including whether infection with different serotypes is associated with distinct types of T cell responses, whether any HLA alleles are associated with pathogenesis or protection, and whether vaccination with a formulation in clinical trials is associated with T cell responses similar to those following infection that might serve as correlates of protection.

The kinetics of the acute response were characterized by rapid expansion of activated T cells, followed by a contraction phase.

The 5 surviving patients developed a mean of 983 host CD3 (+) T cells / mm (3)(range, 536 / mm (3)-1574 / mm (3)-RRB-, a mean of 437 recent thymic emigrants / mm (3)(range, 196 / mm (3)-785 / mm (3)-RRB-, and normal proliferative responses to phytohemaglutinin (follow - up from day 376 to day 873).

IFITM3 inhibited IL - 6 production by myeloid cells in response to replicating and nonreplicating virus as well as following stimulation with the TLR ligands Poly (I: C) and CpG.

Historically, many vaccines have been designed to evoke an antibody response by B cells following inoculation with weakened or dead pathogens.

Induction of IL17 following S. aureus bioparticle challenge was compromised in mice lacking the ASC (Apoptosis - associated speck - like protein containing a CARD) inflammasome subunit (Figure 1G), consistent with a role for IL1β in activating IL7RαhiCcr6 + cells during the response to these bacteria.

Intestinal permeability was assessed by Ussing chamber; epithelial cell (EC) ultra-structure by electron microscopy; RNA expression of genes coding for junctional proteins by Q - real - time PCR; immune response by in - vitro antigen - specific T - cell proliferation and cytokine analysis by cytometric bead array; intestinal microbiota by fluorescence in situ hybridization and analysis of systemic antibodies against intestinal microbiota by surface staining of live bacteria with serum followed by FACS analysis.

Muscle cells ordinarily contain significant levels of glutathione, and its depletion leads to mitochondrial damage.23 Patients undergoing surgical trauma have been found to exhibit reduced glutathione levels in their skeletal muscles.21 It is tempting to speculate that cholesterol sulfate provides the sulfur needed for glutathione synthesis, so that the deficiency would be explained by the reduced availability of cholesterol following the immune system's heightened response to surgical trauma.

LOS ANGELES, March 9, 2009 — The following is a statement issued by Eli Broad, founder of The Broad Foundations, in response to President Obama's reversal of federal stem cell restrictions:

Lloyd's follow up survey on bikes and cell phone use also prompted some strong responses, and the debate continued over on our Facebook page too.