Sentences with phrase «cell responses needed»
However, recent studies suggest that the threshold of T cell responses needed to eradicate leukemia cells is different from the responses threshold required for mediating GVHD.
http://www.jimmunol.org/ Not exact matches
There are cells within our bodies that are responsible for initiating inflammatory responses when needed.
Vitamin A (the body converts beta - carotene into vitamin A) is needed for the development of cells which carry out this response.
«We also showed that, once the NOD2 pathway trigger is initiated, the cells need a second, amplifying step to complete a full - strength immune response.»
But he added, «We need to improve the memory responses of T and B cells to make longer - lasting vaccines.»
«If we learn how to control dendritic cells, we could strengthen our immune response to infection when needed, or weaken the action of certain immune cells that attack the body's own tissues in autoimmune disease.»
However, some mice experienced dangerous levels of brain swelling, a side effect of the immune response triggered by the engineered cells, the researchers said, adding that extreme caution will be needed to introduce the approach in human clinical trials.
«In addition to creating new beta cells, another issue that needs to be addressed to achieve a cure for type 1 diabetes is that any new beta cells will be attacked by the autoimmune response present in every patient with type 1 diabetes.
The reason for the reduced glucose levels associated with bacterial meningitis was believed to be the need for glucose as fuel by infiltrating immune cells in response to infection.
«Our study suggests that although you need to have some level of IgE to trigger a food allergy response, you also have to produce MMC9 cells to get a severe response and anaphylaxis,» says Yui - Hsi Wang, PhD, lead investigator and a researcher in the Division of Allergy and Immunology at Cincinnati Children's.
«Additionally, this provides evidence needed to begin investigating a vaccine in human cancer clinical trials to determine whether genetically modified tumor cells producing IL - 15 and IL - 15Rα may induce anti-cancer responses.»
T cells and B cells reside there, and that's where you need to get the vaccine to get an immune response.
For an inflammatory response to occur, immune cells need to be present, and these cells travel throughout the body in blood.
Researchers also found that those needing sinus surgery had higher levels of eosinophils, white blood cells central to the body's immune response, even before they responded to the disaster.
Muscle cells, which contract in response to an external signal, are needed to pump blood through the body or to move body parts.
Experiments with mouse embryo support cells that express mutant DUB or pseudo-DUB proteins show an impaired immune response when infected with a virus and impaired DNA damage repair when exposed to ionizing radiation, further validating the need for complex's correct structure.
Electrophysiological recordings of these cells after culture for about 15 weeks revealed proper responses to currents and to inhibition of receptors needed for normal cerebellar signaling, indicating that function had developed along with structure.
Across tumor and cancer types, cancer cells rely on the heat shock response and HSF1 to support the production of vast quantities of proteins and the high - energy demands needed to propel malignancy.
«Systems in the cell that need to work together — such as protein translation and the heat shock response — actually are linked together.
In a paper published online in Diabetes on January 26, biologists in the labs of Joslin Principal Investigator Rohit N. Kulkarni, M.D., Ph.D., and Anil Bhushan, Ph.D., at the University of California at Los Angeles used a genetic approach to show that a protein called cyclin D2 is needed for this beta - cell response in mice.
We were interested in understanding regulation of T cell responses and I began to suspect that, in addition to positive signals that need to be given to initiate immune responses, there are also negative signals that no one had really thought of before that might limit responses.
Four years ago several groups found that the body has two types of prostaglandin H2 synthase: an ever - ready PGHS - 1, present in nearly all cells for basic housekeeping duties, and PGHS - 2, made only as needed and just by those cells involved in inflammation and immune responses.
He uncovered a protein called Yap1 — a pivotal gene switch in a biochemical circuit called the Hippo pathway — that tamps down or ratchets up the division of cells in response to physiological needs.
Using gene - targeted mice and human cells that lack specific components of the immune system, a better understanding of the immune response to DENV and ZIKV is critical for developing much - needed vaccines and antivirals.
«We found that mouse polyomaviruses with a single amino acid change in their shell elicit a very different magnitude and quality of the T cell response that is needed to control the infection,» Lukacher said.
B cells, which manufacture antibodies and are key players in our adaptive immune response, need to undergo several developmental stages before reaching maturity.
«T cells, whether they are helper or killer, need to move to do their work, which is to get to the site of an infection and orchestrate a response,» Ahern says.
Stephan's nanoparticles also have the potential to help make current immunotherapies more effective by providing T cells with nanoparticle «backpacks» to carry the right mix of molecules that T cells need to survive and sustain a robust anti-cancer response.
«There was prior evidence that NK cells are important in combating HIV infection, but we need to learn more about their response,» said Dr. Margaret Costanzo, an immunologist and first author of the paper.
The body thinks you need this amount to get the sugar out of your blood and into your cells in order to sustain your energy to the flight or fight response.
Secondary messengers acts to repair the doorbell so that the cell doors open in response to glucose, resulting in less insulin needing to be secreted.
Secondary messengers acts to repair the doorbell so that the cell doors open in a timely response to glucose, resulting in less insulin needing to be secreted.
In 2006, a study at the University of California in Los Angeles demonstrated that the body's cells need vitamin D to trigger the immune response to bacterial threats.
Muscle cells ordinarily contain significant levels of glutathione, and its depletion leads to mitochondrial damage.23 Patients undergoing surgical trauma have been found to exhibit reduced glutathione levels in their skeletal muscles.21 It is tempting to speculate that cholesterol sulfate provides the sulfur needed for glutathione synthesis, so that the deficiency would be explained by the reduced availability of cholesterol following the immune system's heightened response to surgical trauma.
(One I am struggling with if anybody can help) We need oxidation to provide energy and create weapons systems for cell control immune response etc..
There are cells within our bodies that are responsible for initiating inflammatory responses when needed.
As I'm not a scientist, there was much of your response that sailed over my grey matter, yet most of it tickled enough brain cells to understand your answers and the complexity of what still needs to be learned about everything that is currently happening in the arctic regions.
We can expect a more free flow of this capital into secondary markets; alternative real estate assets, such as cell towers, outdoor advertising and other infrastructure; renovation and redevelopment, such as office space in rehabbed industrial space; and alternative property types, such as medical offices, seniors housing, data centers and lab space, in response to demographic and technology needs.