Sentences with phrase «cell responses with»

Targeting 4 - 1BB (CD137) to enhance CD8 T cell responses with poxviruses and viral antigens.

ß1 - Adrenergic Receptor Contains Multiple IAk and IEk Binding Epitopes That Induce T Cell Responses with Varying Degrees of Autoimmune Myocarditis in A / J Mice.

We will combine our expertise on anti-cancer T cell responses with those of IRIBHM and ChemCom on the physiology of GPCRs, of ImmunXperts on cell purification and of iTeos on the development of innovative immune modulators for cancer immunotherapy.

Bioley G, Dousset C, Yeh A, Dupont B, Bhardwaj N, Mears G, Old LJ, Ayyoub M, Valmori D. Vaccination with recombinant NY - ESO - 1 protein elicits immunodominant HLA - DR52b - restricted CD4 + T cell responses with a conserved T cell receptor repertoire.

Not exact matches

KTE - C19 spurred either a complete or partial response in 13 out of 19 patients with large B - cell lymphomas.

Consider Chan Zuckerberg's Biohub, which is embracing big hairy audacious projects like mapping every cell in the human body (with university partners Berkeley, Stanford, and UCSF) and developing a «universal diagnostic test» and rapid - response team for emerging pathogens.

In December, SQZ partnered with global pharma firm and cancer treatment leader F. Hoffmann - La Roche in a deal that could be worth $ 500 million or more — a large undisclosed upfront payment, and additional sums when SQZ meets certain milestones — to speed up the development of its technology specifically to inject a person's immune cells with a protein to activate a «killer T» cell response to fight off cancer.

During a raid, officers with the jail's Direct Action Response Team clear out inmates from sections of the jail, frisk them, and turn over their cells in search of the contraband.

The biotech specialist said that its updated phase 2 data in a study of its poziotinib candidate treatment for non-small cell lung cancer resulted in a preliminary confirmed objective response rate and potential progression - free survival benefit in patients with the EGFR Exon 20 Mutant form of the disease.

We are all born with instincts, which include the inate knowledge to use our bodies... inate fear responses (fight flight or reason) etc.... all incredible knowledge... yet ALL of that knowledge must come from ONE single cell... The information MUST be stroed electrochemically... but how?

Not surprisingly, President Obama received high marks from the journal, largely because his response to the question of whether he would lift Bush's ban on the federal funding of new embryonic stem - cell lines is in line with the view of most in the scientific community.

Looking people in the eye, listening to what they have to say and making an intelligent response that lets them know we really heard what they were saying, not acting like we're in a hurry to move on but have time to listen, letting them know they are more important than our stupid cell phones, encouraging them and letting them know we think they can succeed — all of those things are extremely important in building relationships, including relationships with homeless people.

Since God does not have a monopoly on power, God's will - and consequently God's response to prayers consonant with the divine will - can be and sometimes is thwarted by the recalcitrance of non divine actualities, whether persons or cancer cells.

The DACS - W checkweighers feature Ishida's unique DSP (Digital Signal Processing) chip which permits accurate signal processing under a wide range of weighing conditions, together with an Ishida built load cell that delivers high sensitivity, response and accuracy.

White blood cell count increases with vigorous crying, suggesting the body is preparing a survival response.

Avoid foods and drinks with lots of sugar as sugar can interfere with immune response (white blood cells) for up to 6 hours after consumption.

The Force spokesman added:» The Inspector General of Police, Ibrahim Idris, deployed Police Special Intervention Force, comprising five units of the Police Mobile Force, five Cells of Counter Terrorism Unit, Conventional Policemen, Special Anti - Robbery Squad, Intelligence Response Team, Technical Intelligence Unit, SIB, detachment of EOD and Police K9 (Sniffer Dogs Section), with their Headquarters in Ile - Ife, led by the Commissioner of Police in charge of PMF, Force Headquarters, Abuja.

Each factor involved in the tumor response — whether it is the speed with which chemotherapeutic drugs reach the tissue or the degree to which cells signal each other to grow — is characterized by a mathematical equation that captures its essence.

This allowed them to track changes in calcium ion concentrations in the cells around wounds in living tissue (as opposed to the cell cultures used in many previous wound response studies) and to do so with an unprecedented, millisecond precision.

«Didn't seem to have a good response to the question about his previous experience with our cell line.

Scientists could build chips containing cells from patients with specific genetic mutations, which could predict drug responses in specific populations, as well as personalized chips that predict an individual's drug response.

When the team compared the types of immune cells activated in the fetus with those in the mother, there were clear differences, suggesting that fetuses generate an independent immune response to CMV (Journal of Experimental Medicine, DOI: 10.1084 / jem.20090348).

On its own, this immune response had no immediate effect in the fight against the utilized breast tumors, but in combination with the ADC it proved itself effective in attacking cancer cells in mice, resulting in the complete cure of the majority of mice receiving the combination therapy.

Glial cells in the spine may activate when pain - related neurons are firing, dosing both limbs with inflammatory substances that may trigger an excitatory response but that may also be toxic to nerves.

«This model was trained on genetic data from human tumors in The Cancer Genome Atlas and was able to predict response to certain inhibitors that affect cancers with overactive Ras signaling in an encyclopedia of cancer cell lines,» Greene said.

«As you look for methods to discern complex immune responses in human cells, more and more people look at what genes are turned on with infections or vaccination procedures.»

With our human gut - on - a-chip, we can not only culture the normal gut microbiome for extended times, but we can also analyze contributions of pathogens, immune cells, and vascular and lymphatic endothelium, as well as model specific diseases to understand complex pathophysiological responses of the intestinal tract.»

In comparison with African strains, infection by the Asian strain of Zika virus more potently affected the p53 gene and genes connected with cells» responses to viral infection, such as interferons.

Furthermore, the team found that ONA inhibited the pro-tumor functions of myeloid derived suppressor cells (MDSC), which are closely associated with the suppression of the anti-tumor immune response of host lymphocytes, by using preclinical sarcoma model.

«That observation is in line with the usual response of cells to oxygen deprivation: they save on the consumption of oxygen by converting glucose to lactate instead of burning the glucose.

With reckless ambition, I decided to add this fusion back into cells and then screen for mutants that could not either switch on or switch off the response to heat shock.

Loss of LKB1 by regulatory T cells was also associated with increased levels of signaling molecules or cytokines associated with the Th2 immune response, Kai said.

They demonstrated that non-obese diabetic (NOD) mice treated with a specific (AID / RAD51) pathway inhibitor had larger populations of certain B cells that were capable of suppressing diabetogenic T cell responses, and greatly reduced T1D development, compared with untreated controls.

Working with human immune cells in the laboratory, Johns Hopkins researchers report they have identified a critical cellular «off» switch for the inflammatory immune response that contributes to lung - constricting asthma attacks.

«Our findings suggest that people who have sufficient dectin - 1 in the cells that line their airways won't experience an allergic response when exposed to airborne dust mites or related allergens — but people with a defect in dectin - 1 expression will lack this protection,» Wills - Karp says.

Essentially, he's looking for immune cells with barcodes that proliferate in individuals with a good response, as opposed to those in whom the vaccine is ineffective.

With treatment, T - cell subtypes normally associated with allergic responses diminished, while a novel T - cell population that likely would not mount an allergic response expanWith treatment, T - cell subtypes normally associated with allergic responses diminished, while a novel T - cell population that likely would not mount an allergic response expanwith allergic responses diminished, while a novel T - cell population that likely would not mount an allergic response expanded.

«In addition to creating new beta cells, another issue that needs to be addressed to achieve a cure for type 1 diabetes is that any new beta cells will be attacked by the autoimmune response present in every patient with type 1 diabetes.

It is the stuff of dreams for flu scientists, but it could be within reach if a new type of vaccine that elicits an immune response from white blood cells is combined with traditional vaccines.

The group's next step is to perform new in vitro trials with different cell types to evaluate the immune response and toxicity.

To better understand how this abnormal distribution of B cell types in people with uncontrolled HIV affected their immune response to the virus, researchers compared HIV - specific antibodies derived from both TLM and RM B cells.

«We therefore investigated responses to the active form of vitamin D in immune cells from the inflamed joints of patients with rheumatoid arthritis.

Yanhai Yin, a professor of genetics, development and cell biology and a Plant Sciences Institute Faculty Scholar, said the biological processes that oversee plant growth and drought response often clash with one another.

In this study, the researchers noted that conventional approaches to modifying organisms to consume novel nutrients constitutively (i.e. with no «off switch») can lead to inefficiencies when the nutrient metabolic pathways are not linked to downstream pathways for stress - responses, cell growth and other functions important for the health of the organism.

Three of the genetic regions associated with PSC fall within a single biological system that underlies variation in T cells, cells important to our immune response.

To demonstrate that the implants could influence the pain pathway in nerve cells, the researchers activated a pain response with light.

The results were encouraging; treatment with virus - specific cells resulted in a 92 percent overall complete or partial response rate.

«When mosquitoes are infected with these viruses, there's a signal that lets the mosquito's cells know that they are infected, resulting in targeting of the virus by the mosquito's immune response.

Experiments in cells with an inactivated form of Argonaute — which contributes only to the antiviral and not the gene regulation activity of RNAi — confirmed that they were observing an antiviral RNAi response.

An example of associative memory would be if the cell learned a response to one stimulus and could then use that response when faced with a second stimulus that is similar to the first.