Sentences with phrase «cell responses within»

Not exact matches

Referring to Plato's depiction of a «world soul» in the Timaeus, Hartshorne posits that just as people have a mutual relationship of response and reaction between the cells of their body and themselves, there is a similar mutual relationship of feeling between God and cell - like elements within the world: atoms, cells, people.

In addition, Red Star Nutritional Yeast contains other beneficial components, such as beta - 1,3 glucan and mannan, complex carbohydrates known to improve the immune response and help maintain cholesterol levels that are already within a healthy range; trehalose, a disaccharide that helps maintain the health of brain cells; and glutathione, an antioxidant that plays an important role in cellular defense mechanisms.

There are cells within our bodies that are responsible for initiating inflammatory responses when needed.

After 10 days of smoke exposure, the scientists found an overall increase in DNA damage responses to so - called reactive oxygen species within the cells.

The research, published and featured in the Spot Light section of the December edition of the Journal of Virology, examines a previously unknown connection between flaviviruses — a classification of viruses that include West Nile virus, Dengue virus and tick - borne encephalitis virus — and organelles (a specialized subunit within a cell) known as peroxisomes that help coordinate the body's immune responses.

Using cells from cadavers, doctors have been experimentally transplanting pancreatic islets into humans for decades, but as many as 60 percent of the transplanted islets die immediately because they are cut off from their blood supply and are killed by an immune response due to direct injection into the bloodstream, and those that survive the transplant usually die within several months.

It has been particularly difficult to measure changes in electrical functions of cells grown within Organ Chips that are normally electrically active, such as neuronal cells in the brain or beating heart cells, both during their differentiation and in response to drugs.

Further animal studies by Kipnis and others show that learning new tasks triggers a mild stress response within the brain, which prompts CD4 cells to rally to the meninges, the membranes that surround the brain.

It is the stuff of dreams for flu scientists, but it could be within reach if a new type of vaccine that elicits an immune response from white blood cells is combined with traditional vaccines.

Three of the genetic regions associated with PSC fall within a single biological system that underlies variation in T cells, cells important to our immune response.

The new study shows that Vibrio bacteria elicit a much more rapid response, with large percentages of cells mating within hours.

Building on the newly - published pilot study, the team will conduct experiments using a windtunnel which measures the behaviour of mosquitoes towards odours and electrodes which track the response of individual odour - detecting cells from within the antenna of the mosquito in specially - designed secure laboratories at the School to measure the responses of malaria - infected Anopheles gambiae s.s. females to human odours.

To figure out what's really happening within an organism — or within a particular organ or cell — researchers are linking the genome with large - scale data about the output of those genes at specific times, in specific places, in response to specific environmental pressures.

The researchers assume that this is the signal that sparks off the response: The bacterial cell now boosts the synthesis of a second messenger, which in turn stimulates the production of an adhesin that firmly anchors the bacteria on the surface within a few seconds.

This «wound - healing» aspect of the immune response stimulates growth of new cells within damaged tissue and brings extra nutrients and oxygen into the injured tissue.

A compartment discovered within certain immune cells is almost certainly the place where a vital step in the immune response takes place.

This gene is associated with cytokinin responses within the plant cells and is fused with a jellyfish protein that glows green when turned on.

The researchers found that the gene expression levels in immune cells changed in response to the macaque's new social rank within 3 months of establishing the new groups, and the cells got better at fighting infection.

In vivo, primary and secondary cytotoxic T cell responses against vaccinia and lymphocytic choriomeningitis virus were within normal ranges.

In the study, the researchers detected a very small number of SIV infected cells in the gut within initial 2.5 days of viral infection; however, the inflammatory response to the virus was playing havoc with the gut lining.

To explore the role of DNA repair in translocation formation, the researchers inhibited key components of the DNA damage response machinery within cells and monitored the effects on the repair of DNA breaks and translocation formation.

Inflammation response induces the transcription of the Irg1 gene and enhancer RNAs, causing the emergence of novel enhancer regions and a novel enhancer landscape within a cell.

The classical concepts of angiogenesis consider the endothelial cells within tumors as a rather passive cell population that merely reacts in response to growth factors released by the tumor cells.

The researchers concluded that in the early stages after stroke, improvements in voluntary movement can be attributed to a reduction in brain swelling because of the trauma and other spontaneous repairs, while later improvements result from «neuronal plasticity» — the reorganization or regeneration of nerve cells within the spinal cord in response to changes in the nerve network.

To study this barrier and determine why a lack of blood flow causes it to leak, the researchers built a blood - vessel - on - a-chip model consisting of a channel lined with a layer of human endothelial cells surrounded by extracellular matrix within a microfluidic device, which allowed them to easily simulate and control the flow of blood through a vessel and evaluate the cells» responses.

Taken together, these findings indicate different redox requirements for the glutathione thiol / disulfide redox couple within cytosol and mitochondria of resting cells and reveal distinct regulation of their redox poise in response to inhibition of glutathione biosynthesis.

They suggest instead it could be an adaptive response within normal liver cells.

Learn how dendritic cells maintain a local antitumor immune response within the tumor microenvironment

He adds, «This study was actually a pilot project for a much larger effort within the Center for Molecular Therapeutics to map responses against drug combinations across hundreds of cancer cell lines, not just melanoma, and look for novel combinations that will benefit subsets of patients regardless of the particular type of tumor they have.

Dr. Veenstra joined NCI - Frederick in the fall of 2001 to implement a state - of - the - art mass spectrometry center that focuses on the discovery of signaling pathways and networks that are activated within cells as a response to external perturbations.

Massive blood transfusions — defined as transfusing at least 10 units of red blood cells within 24 hours — are given to patients experiencing severe blood loss, often in response to traumatic injuries but also in the context of procedures like cardiovascular surgery or liver transplantation and even in some non-surgical patients.

Within two weeks of oral administration, TAC mice that received just Bifidobacterium species had a marked increase in the anti-tumor T cell responses.

Inclusion Criteria: • Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 • Have histologically or cytologically confirmed advanced or metastatic non-small cell lung cancer (NSCLC)(Stage IIIb or greater) • Measurable disease, as defined by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 • Known PD - L1 tumor status as determined by an immunohistochemistry (IHC) assay performed by the central laboratory on tissue obtained at Screening • A woman of childbearing potential must have a negative highly sensitive serum (beta - human chorionic gonadotropin [beta - hCG]-RRB- at Screening within 14 days prior to study drug administration Inclusion Criteria for Crossover: • Participants must have been randomized to Arm A of the study and had radiographic disease progression according to RECIST 1.1 • Participants must have a mandatory biopsy at the time of disease progression according to RECIST 1.1 prior to crossing over.

Dr. Levitsky: My organization within Roche, Pharma Research and Early Development (pRED), has invested in antibody engineering, not only for use of monoclonal antibodies in the established ways of delivering cell - killing agents to tumors or interrupting cell signalling pathways, but also as ways to engage and manipulate the immune system's response to tumors.

When activated by VTX - 2337, TLR - 8 prompts dendritic cells within tumors to secrete factors that fuel a cascade of immune responses.

In turn, the slow but steady buildup of damaged cells within tissues is expected to intensify DDR responses over time.

In 1963, Hruban and colleagues showed that damaged structures within a cell were sequestered and degraded, and that this was a normal and beneficial response to cellular injuries such as starvation or oxygen deprivation.

Because the drug's mode of action was known and patients» response to treatment could be precisely monitored, Michor and colleagues used modeling methods and data from patients in a large clinical trial to identify a group of copiously self - renewing stem cells, which persist within the tumor, resist the drug, and sustain the cancer.

Scientists at the Pacific Northwest National Laboratory have added to the understanding of ERK with proof that ERK oscillates within cells; that is, it cycles continuously in and out of a cell's nucleus in response to cellular growth cues.

Using a combination of biochemical and genetic approaches, Darnell's lab discovered that the immune systems of PND patients thwart tumors with what is essentially an antiviral response: The patients» T cells produce CD8 + killer T cells that recognize the neuronal antigens present within their tumors.

Making use of cell and animal models, my laboratory group addresses some of the fundamental questions of how ethanol exposure injures the liver, with a goal ofidentifying the individual targets of ethanol - induced injury and the specific responses of the key cell types within the liver, as well as the integrated, organismal response to this ethanol - induced injury.

We found that old animals bearing CD8 + TCE within Vbeta10 or Vbeta8 families failed to mount an effective immune response against HSV - 1, as judged by reduced numbers of peptide - major histocompatibility complex tetramer + CD8 T cells and an absence of antiviral lytic function.

A unique focus of my work is on the impact of heterogeneity within tumors and tumor cell populations, including subpopulations commonly referred to as «cancer stem cells», on the immune response.

To assess whether this is occurring within breast cancer cells in response to hypoxia - induced activation of ER - α, EGFR signaling was blocked with the inhibitor gefitinib.

Cortisol stimulates glucose production within the liver and muscle cells, increasing blood sugar levels in order to prepare for a fight or flight response.

Because reflexes are fueled by ATP that is already free within the muscle cell, continuous reflex responses only last for 12 - 15 seconds.

There are cells within our bodies that are responsible for initiating inflammatory responses when needed.

The reparative phase occurs within 3 to 14 days after injury and is characterized by the cellular response of fibroblasts and endothelial cells.

The virus will spread through the body in lymphocytes and monocytes (white blood cells involved in immune responses) and within a few weeks will spread to the bone marrow.

India's move to impose anti-dumping and safeguard duties on solar photovoltaic cells and modules has evoked mixed responses within the industry even as investments and capacity addition fall