Sentences with phrase «cell sequencing approaches»

Not exact matches

That's attached to the progress of sequencing technology, the ability to edit cells, and other gene editing approaches have been transformative in the immunotherapy world in recent years.

Through a variety of «high tech» approaches, including the isolation of monoclonal antibodies from single B cells and ultra-deep sequencing of shifting viral populations over more than three years of infection, the researchers studied one woman who developed potent broadly neutralizing antibodies.

The team integrated three, complementary gene sequencing approaches to look for mutations in tumor cells from SS patients: whole - genome sequencing in six subjects, sequencing of all protein - coding regions (exomes) in 66 subjects, and comparing variation in the number of copies of all genes across the genome in 80 subjects.

To tackle the challenge, the team developed a new approach, called 3D assembly, which determines the sequence of each chromosome by studying how the chromosomes fold inside the nucleus of a cell.

Without this approach, the results of genomic sequencing would have been swamped with DNA from normal cells, making it difficult to detect cancer - linked DNA errors, Papp says.

Various procedures are currently available to detect genetic defects in embryos prior to implantation, but these approaches are often invasive, requiring the removal of cells from the growing embryo, and do not simultaneously detect both chromosomal abnormalities and DNA sequence variations associated with genetic disorders.

The Korbel group combines experimental and computational approaches, including single - cell sequencing technology, to unravel determinants and consequences of germline and somatic genetic variation.

The V Foundation funds will allow Deshpande's team to apply an advanced sequencing - based approach to identify and validate potential targets for drugs that restore cancer cells» epigenome to normal.

Here we utilized BD ™ AbSeq, a novel protein sequencing approach enabled by oligo - conjugated antibodies, for simultaneous detection of mRNA and protein in single cells.

New sequencing approaches are being developed with the Technische Universität Münich (H. Prokisch, PhD) and stem cell therapy with the Sampaolesi, PhD (Interdepartmental stem cell institute of the KU Leuven, Belgium).

We focus on squamous tissues, the skin epidermis and the lining of the oesophagus, using transgenic models, novel sequencing approaches, live imaging and single cell analysis to uncover key steps in cancer development, with aim of developing rational interventions to decrease cancer risk.

We have developed a sequencing based approach to show similar in human tissues, finding around a third of cells in normal sun exposed facial skin carry cancer driver gene mutations.

Expertise in at least one of the following areas is desired: bone biology, stem cell biology, mouse models, and high - throughput sequencing approaches for RNA and chromatin.

One such approach involves the study of a person's «genome,» which is the entire set of genetic instructions found in a cell — an amazing 3.1 billion bases of DNA sequence.

The single - cell RNA sequencing approach of the Human Cell Atlas will allow researchers to create cell profiles based on molecules other than protecell RNA sequencing approach of the Human Cell Atlas will allow researchers to create cell profiles based on molecules other than proteCell Atlas will allow researchers to create cell profiles based on molecules other than protecell profiles based on molecules other than proteins.

«Our analysis of null embryos shows how single - cell RNA sequencing can provide a widely applicable approach for re-evaluating the function of key regulators», said John Marioni.

Coinciding with CIRM's goals, three of the floors planned for renovation will accommodate the collaborative work of top stem cell researcher and UCSB professor James Thompson, who was the first to isolate human embryonic cells in 1998; the new Mellichamp and Ruth Garland Chairs of bioengineering and molecular mechanisms, respectively; and the «Deep Sequencing Core,» which will house, among other things, a device that will help develop new genetic approaches to important cell biology inquiries.