«We found several distinctions between sensitive and resistant models detected at the single - cell level, which testified to single -
cell sequencing potential usefulness for understanding how these cancers may develop resistance.»
Not exact matches
The need to compare multiple
cells» DNA
sequences to distinguish genuine genetic variants from artifacts limits some of the
potential of single -
cell sequencing.
«This study demonstrates the
potential of combining functional profiling of
cells with the characterizations of cancer genomes via next generation
sequencing,» said co-senior author Jill P. Mesirov, PhD, professor and associate vice chancellor for computational health sciences at UC San Diego School of Medicine.
Sequencing the genome allowed researchers to identify the gene for lysin, an enzyme that the virus uses to kill bacterial
cells, that has
potential use as an antibiotic or disinfecting agent.
The ability of the ITAM
sequence to make
cells cancerous represents a
potential new trigger for breast cancer in humans, say the researchers, and gives further credence to the idea that viruses can cause human breast cancer.
The field of single -
cell sequencing is rapidly expanding, with the
potential to precisely study how the basic building blocks of life function and evolve.
The V Foundation funds will allow Deshpande's team to apply an advanced
sequencing - based approach to identify and validate
potential targets for drugs that restore cancer
cells» epigenome to normal.
From widening the scope of model organisms to uncovering the inner workings of
cells, for molecular biologists the human genome
sequence has untold
potential as a final frontier for exploratory science.
REPAIR has the ability to reverse the impact of any pathogenic G - to - A mutation regardless of its surrounding nucleotide
sequence, with the
potential to operate in any
cell type.