Methods: The team profiled lipids using analytical chemistry techniques and monitored changes in
cell shape using capabilities in the Quiet Wing at EMSL, a Department of Energy national scientific user facility located at PNNL.
Not exact matches
It turns out
cells use two different ring -
shaped proteins called condensins to do...
The compound (right panel) has a scorpion - like
shape with two arms grabbing EphA2 - expressing cancer
cells, and a tail (brown) constituted by a cytotoxic chemotherapeutic agent (paclitaxel
used in this work).
Donald Ingber, M.D., Ph.D., Founding Director of the Wyss Institute at Harvard University, started investigating this «architecture of life» over thirty - five years ago, and discovered that Nature
uses an architectural principle known as «tensegrity» (short for «tensional integrity») to stabilize the
shapes of living
cells and to determine how they respond to mechanical forces.
To guide ECM growth in particular alignments, the researchers
used molds with very specific
shapes, often constrained by pegs the
cells had to grow around.
So far the blocks have been
used to build a variety of living 3D
shapes that have never before been created on a
cell - by -
cell basis, such as tubes and solid spheres.
Using this mixture, the researchers were able to print living
cells in a specific architecture, such as an ear
shape, that maintained its form even after printing.
One example of this research is the practice of
using stem
cells taken from a healthy eye's limbus, the area around the cornea where stem
cells are stored, to create a layer of healthy
cells to replace damaged ones in the cornea, the transparent, dome -
shaped layer of
cells covering the front of the eye.
While mouse models have traditionally been
used in studying the genetic disorder, Deng said the animal model is inadequate because the human brain is more complicated, and much of that complexity arises from astroglia
cells, the star -
shaped cells that play an important role in the physical structure of the brain as well as in the transmission of nerve impulses.
To test that idea in the ragworm, Tomer
used a technique he had developed to examine the complex brains of small creatures with unprecedented clarity: He created a high - resolution map of the worm's brain
cells according to the genes they express, not just their
shape and location.
The Spanish scientists examined the
shape of the magnetosomes and their arrangement inside the
cells using various experimental methods such as electron cryotomography.
Called a medusoid, after the umbrella -
shaped class of jellyfish it mimics, the silicone cyborg
uses heart muscle
cells from a rat to recreate the pumping motion of the moon jellyfish, Aurelia aurita.
Depending on which device they buy, researchers can photograph
cells at anywhere from 20x to 60x magnification, and
use the included software to sort them by purely visual characteristics such as
shape and size, fluorescent markers, or both.
Besides devising unique ways to analyze conventional
cell images, researchers are also
using new microscopy techniques to better define
cell shapes.
Despite these frustrations, Davies persisted, discovering that he could
use GRP
cells to generate astrocytes, the star -
shaped structural
cells that play a crucial role in nervous system function right along with neurons.
In a paper published Sept. 21 in
Cell, Harvard Medical School genetics professor Olivier Pourquié — whose lab discovered the segmentation clock 20 years ago — and colleagues report that they
used mouse
cells to reconstitute a stable version of this clockwork for the first time in a petri dish, leading to several new discoveries about where the clock is located, what makes it tick and how the vertebral column takes
shape.
The large rotelle -
shaped molecules also can «catch» other molecules and thus would make effective biological sensors; they also have potential
use in solar
cells and switches, he adds.
To
use RNAi against the pest, the researchers first identified a gene the insect can't do without — one that encodes a cytoskeleton protein vital to maintaining a
cell's
shape.
Before the
cell can
use microtubules for these and other essential functions, it must first organize them into carefully crafted bundles, which become the basis for three dimensional
shapes.
The MIT team hypothesized that natural
shape - shifters such as yeast, bacteria, and other microbial
cells might be
used as building blocks to construct moisture - responsive fabrics.
Such an autocatalytic system also provides an entirely novel mechanism for the growth of ring -
shaped structures, which differs fundamentally from that
used for daughter
cell segregation in eukaryotic
cell division: In eukaryotes, specific motor proteins which attach to the
cell membrane and undergo active contraction are essential for this process, Denk points out.
The team
used patterned photoactivation non-linear SIM to produce videos showing structural proteins break down and reassemble themselves as
cells move and change
shape, as well as the dynamics of tiny pits on
cell surfaces called caveolae.
They then
used a mathematical technique — «gyration tensors» — to reduce each
cell's
shape to a characteristic ellipsoid.
Using variations on their computer model, «we have already computed the
shape of red blood
cells, soap bubble clusters and the evolution of polycrystalline materials,» he says.
They then
used the so - called induced pluripotent stem
cells (IPS
cells) to reverse a mouse version of the genetic disorder sickle -
cell anemia, which causes normally circular red blood
cells to form sickle -
shaped, thereby impeding blood flow.
Researchers have determined the first detailed molecular images of a piece of the spike -
shaped protein that the SARS virus
uses to grab host
cells and initiate the first stages of infection.
Oriented
cell division is
used throughout embryonic development and adult homeostasis to
shape and pattern tissues.
A few years ago, scientists figured out why: the receptor that the virus
uses to get into
cells is
shaped differently in a human nose than it is in a chicken egg.
The researchers also showed that their method can be
used to determine the
shape of the
cell by injecting a dye; they are now working on extracting a
cell's contents to read its genetic profile.
This simulation is
used to model processes such as the formation of a mitotic spindle, or the mechanisms by which
cell shape is determined.
In their first efforts, they
used an actual inkjet desktop printer that was modified to print
cells into a 3D
shape.
Specific antibodies were
used as markers to bind to the structure of motor neurons so that they could be easily viewed under high - power microscopes, and a computer program performed the three - dimensional measurement of the size and
shape of a motor neuron's
cell body.
Year 6 Science Assessments and Tracking Objectives covered: Describe how living things are classified into broad groups according to common observable characteristics and based on similarities and differences, including micro-organisms, plants and animals Give reasons for classifying plants and animals based on specific characteristics Identify and name the main parts of the human circulatory system, and describe the functions of the heart, blood vessels and blood Recognise the impact of diet, exercise, drugs and lifestyle on the way their bodies function Describe the ways in which nutrients and water are transported within animals, including humans Recognise that living things have changed over time and that fossils provide information about living things that inhabited the Earth millions of years ago Recognise that living things produce offspring of the same kind, but normally offspring vary and are not identical to their parents Identify how animals and plants are adapted to suit their environment in different ways and that adaptation may lead to evolution Recognise that light appears to travel in straight lines
Use the idea that light travels in straight lines to explain that objects are seen because they give out or reflect light into the eye Explain that we see things because light travels from light sources to our eyes or from light sources to objects and then to our eyes
Use the idea that light travels in straight lines to explain why shadows have the same
shape as the objects that cast them Associate the brightness of a lamp or the volume of a buzzer with the number and voltage of
cells used in the circuit Compare and give reasons for variations in how components function, including the brightness of bulbs, the loudness of buzzers and the on / off position of switches
Use recognised symbols when representing a simple circuit in a diagram
Hyundai
uses a lithium - ion polymer battery pack for all Ioniq models which is 20 percent lighter than non-polymer lithium - ion batteries and can be
shaped more optimally to the interior than standard
cell format batteries.
Hyundai
uses a lithium - ion polymer battery pack for all Ioniq models which is 20 % lighter than non-polymer lithium - ion batteries and can be
shaped more optimally to the interior than standard
cell format batteries.
Current rumors suggest Apple will continue to
use a two -
cell L -
shaped design for the batteries in the 5.8 and 6.5 - inch iPhones coming in 2018.
A similarly -
shaped, two -
cell is reportedly being
used by the iPhone 8 to help bring about faster charging speeds.
The anniversary iPhone could also come with faster charging
using the new «2 -
cell L -
shaped battery pack design,» according to the report.