Sentences with phrase «cell signaling cascade»

The team discovered that the pain signals from a peripheral injury combined with subsequent morphine treatment worked together to cause a glial cell signaling cascade.

Byron B. Goldstein was recognized for his contributions in the field of mathematical immunology and cell biology, specifically in modeling cell signaling cascades, pursuing cutting - edge research in cell activation, cell - signaling, cell surface receptor - ligand interactions, and the generation of allergic responses.

Not exact matches

Introducing human prostate cancer cell lines into mice, Wu and his colleagues saw a particular enzyme called MAOA activate a cascade of signals that made it easier for tumor cells to invade and grow in bone.

«It's important that it all be viable — if not, not only might cells die in the center of the graft, but they can release bad signals to remaining healthy cells in an «apoptotic cascade,» essentially saying, «Conditions are horrible, let's commit suicide.»»

In subsequent experiments, the Einstein team deciphered other parts of the Rac1 signaling cascade during invasion and showed that this signaling mechanism is regulated differently in normal breast epithelial cells.

CANTOS grew out of years of ups and downs in the heart disease field, as scientists tried to trace the role of inflammation, a complex cascade of immune signals and various white blood cells that occurs in response to wounds, infections, and more.

Multiple sclerosis (MS) is caused by immune cells that activate a cascade of chemicals in the brain, attacking and degrading the insulation that keeps neuronal signals moving.

They call this form of activation «non-ligand-dependent,» and in a complex series of biochemical and animal experiments, traced the pathway through which FER's binding to MET inside the cell sets off a cascade of cell - signaling events, all directly connected in prior research with cancer initiation, including RAC1 / PAK1 and SHP2 - ERK.

In addition to the COX enzyme pathway, Dr. Roberts says other studies have shown that aspirin blocks additional cell - signaling cascades that promote cancer development.

Frigo and his team demonstrated in this study that androgens take control of the AMPK signaling cascade, a master regulator of metabolism, to increase prostate cancer cell growth.

When a THC molecule binds to one of these CB1 receptors, it changes form, triggering a cascade of various signals inside the cell.

By functionally linking the signal transduction of melanopsin to the control circuit of the nuclear factor of activated T cells, we have designed a synthetic signaling cascade enabling light - inducible transgene expression in different cell lines grown in culture or bioreactors or implanted into mice.

Like a cascade, after the first molecule in a pathway receives a signal, it activates another molecule and so forth until the cell function is carried out.

Forward - looking studies are examining other possible information couriers: glial cells (poorly understood brain cells that are 10 times as common as neurons), other kinds of signaling mechanisms between cells (such as newly discovered gases and peptides), and the biochemical cascades that take place inside cells.

When an activating protein docks at the receptor, a cascade of signals is sent inside breast cells.

The scientists» model looks at the EGFR signaling cascade to investigate crosstalk between EFGR signaling and EMT in cell culture models of human breast epithelium.

A phage, blue, blocks a complex cascade of cell - building signals to break down a bacterium «s wall.

When a rod cell in the retina absorbs light, a cascade of reactions results in a nerve signal.

For a long time, scientists were convinced that GPCRs influence the activity of the cell via activation of various intracellular signalling cascades while sitting at the cell surface.

The cascade produces a cell signal from a protein called interleukin - 1beta (IL - 1b), which increases the activity of pain - responsive nerve cells in the spinal cord and brain.

As soon as the calcium level exceeds a particular threshold value over a longer period of time, a signal cascade is triggered that initiates production of the body's tanning pigment melanin in the genetically modified cells.

La Jolla, CA — The cellular cascade of molecular signals that instructs cells with fatally damaged DNA to self - destruct pivots on the p53 tumor suppressor gene.

T. gondii has the capacity to modulate host signaling cascades and remodel its host cells» transcriptomes and proteomes profoundly.

TNA3: BPRC will offer access to its library of human cell reporter assays for the identification of innate immune receptor - induced signalling cascades, including human cell lines transfected with PAMPs such as TLR and / or engineered to express luciferase in response to NF - kB or IFRE - mediated signal transduction, and cell lines that provide insight into the intracellular signalling cascades of innate immune receptors.

The BMP protein acts as an activator for cell — surface receptors, and initiates cellular processes and signaling cascades.

Arginine stimulates proliferation of ovine trophectoderm cells through MTOR - RPS6K - RPS6 signaling cascade and synthesis of nitric oxide and polyamines.

It has been observed that this pathway when is activated by upstream signaling cascades [such as growth factor receptors and G - protein coupled receptors (GPCRs)-RSB-, leads to cell proliferation, differentiation and migration.

We are identifying and characterizing the signaling molecules that control the interphase between cell survival and death cascades.

Melanocytes have the capacity to respond to a diverse number of extracellular signals, including UVR, endocrine signaling cascades that occur during pregnancy, micro-environments of the stem cell hair bulge vs. differentiated hair follicle niches, and hypoxic conditions found in metastatic melanoma tumors.

In biology, a signaling cascade is a series of chain reactions that help cells amplify a particular signal — like a domino effect.

Countering the prevailing theory that cellular hydrogen peroxide signaling is broad and non-specific, Whitehead Institute scientists have discovered that this reactive oxygen species (ROS) in fact triggers a distinct signal transduction cascade under control of the mitochondrial respiratory chain — the Syk pathway — that regulates transcription, translation, metabolism, and the cell cycle in diverse cell types.

«Instead, the Vegf signaling cascade alerts only those MAPKs and ETS factors within the realm of Dll4 — assuring only the correct cells grow and differentiate over time to form arteries.»

The notion that a Nanog positive, ICM - like population of high probability self - renewing cells is a developmental ground state is supported by the expansion of this state in the presence of a blockade on the major signalling pathways known to promote ES cell differentiation, the MAP kinase / ERK cascade and GSK3β [42], [50].

Like in the Wnt signaling pathway, ligands bind to the EGFR on the cell surface and initiate a cascade of events in the cell that in this case lead to regulation of genes that control cell cycle progression.

Suite of biological assays (Autophagy, Apoptosis, Signalling cascades) for investigating interactions of lipid droplets and components with cells

External cues act on tyrosine kinase proteins embedded in the cell membrane to induce a cascade of signals with a vital role in regulating cell proliferation.

BPRC will offer access to its library of human cell reporter assays for the identification of innate immune receptor - induced signalling cascades, including human cell lines transfected with PAMPs such as TLR and / or engineered to express luciferase in response to NF - kB or IFRE - mediated signal transduction, and cell lines that provide insight into the intracellular signalling cascades of innate immune receptors.

They quiet the signal that tells your body something needs fixing and inhibit the cascade of white blood cells that cause inflammation, he says.

Their metabolites accumulate in muscle and fat cells, activate proinflammatory signalling cascades, cause mitochondrial dysfunction, and interfere with insulin - stimulated glucose transport.

In response to increased cellular hydration, the cell initiates a signaling cascade that causes the muscle to grow larger to protect itself.