Sentences with phrase «cell signaling pathway»

Using imaging techniques, the cell signaling pathway can be investigated in detail to target areas that could prevent cancer from developing.

To prevent this from happening patients are treated with a second compound that stops this cell signaling pathway from being unintentionally activated.

By blocking a specific cell signaling pathway in lab animals, researchers reversed signs of chronic immune activation, thereby boosting T - cell recovery and viral suppression.

In a resignation letter to the research community, Varmus decried the harsh budget climate he has faced and pointed to a list of accomplishments, from creating an NCI center for global health to launching a project to find drugs targeting RAS, an important cell signaling pathway in cancer.

Scientists at the Wyss Institute at Harvard University set out to solve the mystery of how blood flow keeps the vessels intact and, to their surprise, discovered a completely new cell signaling pathway that is a promising target for drugs to treat a variety of debilitating conditions.

The effectiveness of the therapy lies in its ability to target a pro-survival cell signaling pathway known as PI3K / AKT / mTOR, upon which the leukemia cells have become dependent.

Jagged1 plays a key role in a cell signaling pathway involved in many body systems, but it was not previously known to affect Duchenne muscular dystrophy.

Targeting stromal cells as well as the cancer cells blocks multiple cell signalling pathways that are used by cancer cells to become aggressive.

They found that these genetic differences were tied to several important developmental and cell signaling pathways.

A cell signal pathway with constitutive activity requires no binding partner (ligand) to activate; instead, the signaling circuit continually activates itself.

The new study, a comprehensive analysis of the genomes of 178 primary cervical cancers, found that over 70 percent of the tumors had genomic alterations in either one or both of two important cell signaling pathways.

One finding was that a cell signal pathway called Wingless and its central signal molecule, beta - catenin, can regulate the production of MGMT in the tumour cell.

One aspect of their work studies how cell signaling pathways, such as those that initiate cell growth or death, are affected by the nanostructures and microstructures of implant materials such as titanium.

Another surprising finding was the direct link between Notch and genes involved in other B cell signaling pathways.

B cell signaling pathways are the current targets of several therapies used to treat B cell malignancies such as CLL.

Cell signaling pathways are a defined series of interactions between proteins that govern biological functions, initiated by receptors on the surface of cells.

The researchers found that in B cell tumors, mutated overactive versions of the Notch protein directly drive the expression of the Myc gene and many other genes that participate in B cell signaling pathways.

These physical effects lead to cell signaling pathways for enhanced cell survival.

«But we have to further study the functions of this histone, identify the other proteins with which it is associated, and determine the enzymes that modify it and why and the cell signalling pathways involved,» explain the scientists.

Dr. Levitsky: My organization within Roche, Pharma Research and Early Development (pRED), has invested in antibody engineering, not only for use of monoclonal antibodies in the established ways of delivering cell - killing agents to tumors or interrupting cell signalling pathways, but also as ways to engage and manipulate the immune system's response to tumors.

Dr. Joyal has over 20 years of drug discovery experience with expertise in cell and molecular biology, particularly in the areas of receptor biology, cell signaling pathways, and assay development.

We use neuronal cultures, induced pluripotent stem (iPS) cells and transgenic and gene - targeted mouse models to study the differential effects of apoE3 and apoE4 on cell signaling pathways and cytoskelatal structure and function at molecular, cellular and behavioral levels.

The results, which were published and highlighted in Molecular Systems Biology, give researchers a more complete view of cell signaling pathways.

The effect of a novel antagonist of growth hormone releasing hormone on cell proliferation and on the key cell signaling pathways in nine different breast cancer cell lines.

Dr. Rebecca Vega Thurber received her doctorate in 2005 from Stanford University where she studied developmental cell signaling pathways in sea urchin larvae.

Epstein - Barr virus, the closest human relative of Kaposi's sarcoma - associated herpesvirus, mimics host B cell signaling pathways to direct B cell development toward a memory B cell phenotype.

For example, studies of cell signaling pathways in normal cells and cancer cells have contributed greatly to our knowledge about the disease, revealing molecular alterations that are shared among different types of cancer and pointing to possible strategies for treatment.

Finally, the strategy applied here for selective delivery of MK801 can be extended to other small molecules for use in brain tissue (Tian et al., 2012), allowing for an approach that combines chemistry, molecular genetics, and neurobiology to dissect cell signaling pathways in specific cell types in the central nervous system.

Research now reveals that luteolin has the ability to restrict the activity of the IGF and PI3K cell signaling pathways necessary for the development of cancer found in cancer cells of the colon.

Luteolin decreased activation of the cell signaling pathways Akt, PI3K, and CDC25c and ERK1 / 2 that are dependent on IGF - I.

It was also discovered that it maintains specific cell signalling pathways necessary for nerve cell survival.

ROS are important signaling molecules for a number of different cell signaling pathways, particularly those associated with stress - response, and we are stress - response machines.

While some amount of omega - 6 s are important for membrane structure and cell signalling pathways (Institute of Medicine 2005), consuming too much can interfere with neurological development through inhibition of omega - 3 PUFA metabolism and availability (Novak et al. 2008).

Not exact matches

He conducted his postdoctoral research at Brigham and Women's Hospital / Harvard Medical School, where he researched the role of the Wnt signaling pathway in mouse models of kidney disease, and was part of a team that discovered a stem cell subtype responsible for solid organ fibrosis.

A Canadian study published this year around the same time titled «Coconut oil protects cortical neurons from amyloid beta toxicity by enhancing signaling of cell survival pathways» observed that coconut oil and its medium chain fatty acids (MCFAs) protect against amyloid beta (Aβ) induced neurotoxicity in primary rat cortical neurons.

One factor keeping cells in this immature state is the PTEN gene, which suppresses a signalling pathway involved in cell growth.

«The pathway mainly involves signalling via the brains» immune cells, and thus differs from how today's drugs operate.

«While transient disruption of this pathway may have therapeutic benefit because it temporarily «revs up» the immune response, permanent loss of PD - 1 signals seems to result in a «flame out» where T cells can't sustain higher level activation and become more dysfunctional,» Wherry says.

In addition to diminishing the tumor's energy supply, the diet slows the growth of glioblastoma cells by altering a cellular - signaling pathway that commonly occurs in cancers, according to the researchers.

Researchers filled in other details about the selective role of LKB1 in regulatory T cells, including that the molecule unexpectedly works through the Wnt signaling pathway to adjust regulatory T cell function.

OMP - 54F28 (FZD8 - Fc) is an antagonist of the Wnt pathway, a key CSC signaling pathway that regulates the fate of these cells.

The group is now pursuing studies that couple the mechanical forces of a blast, or pressure wave, to the activation of chemical - signaling pathways in neural cells.

The network provides an invaluable resource for identifying targets to treat the disease and has been used to implicate a particular signaling pathway involved in cell motility.

LKB1 is known to work through different pathways, primarily the mTORC1 and AMPK signaling pathways, in conventional T cells and other settings.

In particular, HD mutations impacting the RhoGTPase signaling pathway interfered with filopodia, the slender projections that cells use to direct movement and communicate with other cells.

So we'd need to find a way to shut off this signaling pathway specifically in cancer cells.»

Researchers at Albert Einstein College of Medicine of Yeshiva University have discovered a signaling pathway in cancer cells that controls their ability to invade nearby tissues in a finely orchestrated manner.

The new research, reported Nov. 25 in the Journal of Biological Chemistry, investigated the role of two proteins, GRB10 and p70S6K, in the control of the signaling pathway that activates M2 cells.

Several target molecules have also been identified in intracellular signalling pathways and in cell survival proteins.

«Now that we know the cell of origin for Barrett's esophagus, the next step is to develop therapies that target these cells or the signaling pathways that are activated by acid reflux,» said Dr. Que.