Sentences with phrase «cell signaling pathway in»

By blocking a specific cell signaling pathway in lab animals, researchers reversed signs of chronic immune activation, thereby boosting T - cell recovery and viral suppression.

In a resignation letter to the research community, Varmus decried the harsh budget climate he has faced and pointed to a list of accomplishments, from creating an NCI center for global health to launching a project to find drugs targeting RAS, an important cell signaling pathway in cancer.

The effect of a novel antagonist of growth hormone releasing hormone on cell proliferation and on the key cell signaling pathways in nine different breast cancer cell lines.

Dr. Rebecca Vega Thurber received her doctorate in 2005 from Stanford University where she studied developmental cell signaling pathways in sea urchin larvae.

For example, studies of cell signaling pathways in normal cells and cancer cells have contributed greatly to our knowledge about the disease, revealing molecular alterations that are shared among different types of cancer and pointing to possible strategies for treatment.

Finally, the strategy applied here for selective delivery of MK801 can be extended to other small molecules for use in brain tissue (Tian et al., 2012), allowing for an approach that combines chemistry, molecular genetics, and neurobiology to dissect cell signaling pathways in specific cell types in the central nervous system.

Not exact matches

He conducted his postdoctoral research at Brigham and Women's Hospital / Harvard Medical School, where he researched the role of the Wnt signaling pathway in mouse models of kidney disease, and was part of a team that discovered a stem cell subtype responsible for solid organ fibrosis.

A Canadian study published this year around the same time titled «Coconut oil protects cortical neurons from amyloid beta toxicity by enhancing signaling of cell survival pathways» observed that coconut oil and its medium chain fatty acids (MCFAs) protect against amyloid beta (Aβ) induced neurotoxicity in primary rat cortical neurons.

One factor keeping cells in this immature state is the PTEN gene, which suppresses a signalling pathway involved in cell growth.

«While transient disruption of this pathway may have therapeutic benefit because it temporarily «revs up» the immune response, permanent loss of PD - 1 signals seems to result in a «flame out» where T cells can't sustain higher level activation and become more dysfunctional,» Wherry says.

In addition to diminishing the tumor's energy supply, the diet slows the growth of glioblastoma cells by altering a cellular - signaling pathway that commonly occurs in cancers, according to the researcherIn addition to diminishing the tumor's energy supply, the diet slows the growth of glioblastoma cells by altering a cellular - signaling pathway that commonly occurs in cancers, according to the researcherin cancers, according to the researchers.

Researchers filled in other details about the selective role of LKB1 in regulatory T cells, including that the molecule unexpectedly works through the Wnt signaling pathway to adjust regulatory T cell function.

The group is now pursuing studies that couple the mechanical forces of a blast, or pressure wave, to the activation of chemical - signaling pathways in neural cells.

The network provides an invaluable resource for identifying targets to treat the disease and has been used to implicate a particular signaling pathway involved in cell motility.

LKB1 is known to work through different pathways, primarily the mTORC1 and AMPK signaling pathways, in conventional T cells and other settings.

In particular, HD mutations impacting the RhoGTPase signaling pathway interfered with filopodia, the slender projections that cells use to direct movement and communicate with other cells.

So we'd need to find a way to shut off this signaling pathway specifically in cancer cells.»

Researchers at Albert Einstein College of Medicine of Yeshiva University have discovered a signaling pathway in cancer cells that controls their ability to invade nearby tissues in a finely orchestrated manner.

The new research, reported Nov. 25 in the Journal of Biological Chemistry, investigated the role of two proteins, GRB10 and p70S6K, in the control of the signaling pathway that activates M2 cells.

Several target molecules have also been identified in intracellular signalling pathways and in cell survival proteins.

Through the mTOR signalling pathway, it is involved in the regulation of many cellular processes, including cell survival, metabolism, proliferation, differentiation, and senescence.

They call this form of activation «non-ligand-dependent,» and in a complex series of biochemical and animal experiments, traced the pathway through which FER's binding to MET inside the cell sets off a cascade of cell - signaling events, all directly connected in prior research with cancer initiation, including RAC1 / PAK1 and SHP2 - ERK.

Consistent with previous findings, Apc suppression in the animals activated the Wnt signaling pathway, which is known to control cell proliferation, migration, and survival.

But that didn't pinpoint the site of computation; cells earlier in the pathway might be analyzing motion and delivering a larger excitatory signal to the ganglion cells in response to movement in the preferred direction.

Half of all melanomas harbor an activating mutation in the BRAF gene that turns on the cancer signaling pathway in cells known as the MAP kinase pathway.

In addition to the COX enzyme pathway, Dr. Roberts says other studies have shown that aspirin blocks additional cell - signaling cascades that promote cancer development.

Previous research by Lee's lab had shown that p75 is involved in a signaling pathway that regulates the development of sensory neurons — cells which transmit our sensation of pain, touch and muscle tension — in the dorsal root ganglia.

«Signaling pathways and gene expression profiles are very different in cells that grow in 2D and 3D cultures,» says Oksana Sirenko, a research scientist at Molecular Devices in Sunnyvale, California.

Researchers used the new therapy to inhibit a pathway in the cancer cells known as mTOR signaling — putting the brakes on this pathway, combined with the current standard therapy, caused more of the cancer cells to die.

«Elevated calcium triggers multiple signaling pathways that promote cell doubling, survival and changes in the cell that promote cancer invasion and metastasis,» says Dr. Copland.

They were interested in one of the cell's key signaling pathways, the MAPK pathway, which helps control cell growth, embryonic development, and the maturation of oocytes into eggs.

The team's next step is to zoom in on the molecular mechanisms that control how the Wnt signaling pathway interacts with the nail stem cells to influence bone and nail growth.

Her work described the regulatory link between the metabolic enzyme ATP - citrate lyase and histone acetylation levels in mammalian cells, and established that glucose utilization in the hexosamine biosynthetic pathway regulates growth factor receptor signaling.

«We also showed for the first time that AHR signaling in primary human orbital fibroblasts disrupts the pro-fibrotic Wnt / β - catenin pathway, which is important for scar cell formation,» noted Dr. Phipps.

The lipid type, ceramide, also has a functional role in various signaling pathways and affects synaptic function, although its primary role is not in the synapse, but providing structure in cell membranes.

Researchers at Boston University School of Medicine (BUSM), under the direction of Sam Thiagalingam, PhD, found that a protein secreted by BLBC cells, called periostin (POSTN), acted to nurture and support cancer stem cells by activating a distinct signaling pathway in these cells.

To unravel the complex signaling pathway map, the scientists used their own findings from the analysis of factors regulated up or down in the interplay between tissue and stem cells, linking them with the signaling pathways described in existing literature.

Her research has recently shown that a signaling pathway dubbed «hedgehog» is important not only for normal development of stem cells but also for the growth of cancer cells in chronic myelogenous leukemia.

She then followed up with a closer look at role of the Igf2 signaling pathway in coaxing quiescent hematopoietic stem cells to start dividing and maturing into multi-lineage progenitors that ultimately give rise to specialized blood cells.

His lab studies a particular signaling pathway, the RAS / RAF / MEK / ERK pathway, which regulates cell growth and survival in several cancers.

Previous experiments have enabled them to decode a signalling pathway involved in adipose cell maturation and to show that calories in the nutrient medium influence this process.

NANCI appears to act upstream of Nkx2.1, but down - stream of Wnt signaling, a critical pathway for specifying cell type later in lung tissue development.

Dr. Yaffe's research focuses on the biology of the complex signaling pathways that cells use to respond to DNA damage and inflammation, particularly the role of protein kinases and modular binding domains in tumor development and anti-cancer therapeutics.

They focused on ItpkB because it is produced in HSCs, and the Sauer lab and others had previously shown that ItpkB controls a major signaling pathway in other cells that had been implicated in activating HSC.

«In my opinion, age is just a number, and it's not a chronological number of years, but a number representing the strength of signaling pathways within cells,» Conboy says.

Jagged1 plays a key role in a cell signaling pathway involved in many body systems, but it was not previously known to affect Duchenne muscular dystrophy.

The effectiveness of the therapy lies in its ability to target a pro-survival cell signaling pathway known as PI3K / AKT / mTOR, upon which the leukemia cells have become dependent.

The discoveries achieved during this project, which was funded by the Rosetrees Trust of Britain, were published this week in the journal Aging Cell («A novel inhibitor of the insulin / IGF signaling pathway protects from age - onset, neurodegeneration - linked proteotoxicity»).

Imaging flow cytometry (IFC) has emerged as a useful and efficient tool for studying the signaling pathways in immunophenotypically defined subpopulations of immune cells.

«Our results with Drosophila exhibit surprising similarities in some respects to what we know about the regulation of resting phases in mammals, allowing for speculation as to whether the Hippo signaling pathway in neural stem cells functions in the same manner in both vertebrates and invertebrates,» stated the paper's first author Rouven Ding.