Sentences with phrase «cell signaling pathways for»

These physical effects lead to cell signaling pathways for enhanced cell survival.

Not exact matches

He conducted his postdoctoral research at Brigham and Women's Hospital / Harvard Medical School, where he researched the role of the Wnt signaling pathway in mouse models of kidney disease, and was part of a team that discovered a stem cell subtype responsible for solid organ fibrosis.

The network provides an invaluable resource for identifying targets to treat the disease and has been used to implicate a particular signaling pathway involved in cell motility.

«Now that we know the cell of origin for Barrett's esophagus, the next step is to develop therapies that target these cells or the signaling pathways that are activated by acid reflux,» said Dr. Que.

Trametinib is used to treat skin cancer and was chosen for its ability to inhibit Ras signalling as part of the «Ras - Erk - ETS» cell pathway.

«We also showed for the first time that AHR signaling in primary human orbital fibroblasts disrupts the pro-fibrotic Wnt / β - catenin pathway, which is important for scar cell formation,» noted Dr. Phipps.

Her research has recently shown that a signaling pathway dubbed «hedgehog» is important not only for normal development of stem cells but also for the growth of cancer cells in chronic myelogenous leukemia.

NANCI appears to act upstream of Nkx2.1, but down - stream of Wnt signaling, a critical pathway for specifying cell type later in lung tissue development.

Imaging flow cytometry (IFC) has emerged as a useful and efficient tool for studying the signaling pathways in immunophenotypically defined subpopulations of immune cells.

«Our results with Drosophila exhibit surprising similarities in some respects to what we know about the regulation of resting phases in mammals, allowing for speculation as to whether the Hippo signaling pathway in neural stem cells functions in the same manner in both vertebrates and invertebrates,» stated the paper's first author Rouven Ding.

The Hippo signaling pathway, which is highly conserved up to humans, was known to play a critical role in organ size determination, like, for example, in the liver, but has not been demonstrated to influence neural stem cells in the central nervous system.

Janus kinases carry out important intracellular functions in many organs — for instance, activating key signal pathways in the systems which form new blood cells.

«Two components of the pathway, the phosphatase PTPD2 and the lipid PA, are together required for HER2 signaling to function in mammary epithelial cells.»

When the team added TGF - β1 to cells lacking FOX01, the cells behaved normally and produced the proper suite of molecules needed for healing, indicating that FOX01 acts upstream of TGF - β1 in the signaling pathway triggered during the healing process.

The Heidelberg researchers also uncovered an initial indication that another signal path is active in the neurogenesis of sea anemones — the BMP pathway, which is instrumental for the centralization of nerve cells in vertebrates.

According to Prof. Holstein, the origin of the first nerve cells depends on the Wnt signal pathway, named for its signal protein, Wnt.

«For example, mouse mammary tumors shared a signaling pathway that is found in human lung cancer and controls how cells reproduce and move from one location to another.»

When the IP3R calcium channel receives signals, it creates a pathway for calcium ions to move across cell membranes.

«We hope this atlas will be a roadmap for the field to explore the relationship between specific cell types, signaling pathways, receptors, and the physiological function of brain circuits,» Kriegstein added.

«There has been a lot of work on Wnt signaling pathways, for example, so there are a lot of small - molecule drugs that could be tested to trigger a stem cell to mature into a neuron.»

For their study, the researchers examined the Fanconi anemia signal pathway, which coordinates the complex repair of crosslinks, with the aid of genetically modified and unchanged cells.

Scientists at the Wyss Institute at Harvard University set out to solve the mystery of how blood flow keeps the vessels intact and, to their surprise, discovered a completely new cell signaling pathway that is a promising target for drugs to treat a variety of debilitating conditions.

In a resignation letter to the research community, Varmus decried the harsh budget climate he has faced and pointed to a list of accomplishments, from creating an NCI center for global health to launching a project to find drugs targeting RAS, an important cell signaling pathway in cancer.

And the one with «significant flaws» was the Alliance for Cell Signaling, which set out to map cell - signaling pathways in heart muscle cells and immune ceCell Signaling, which set out to map cell - signaling pathways in heart muscle cells and immuSignaling, which set out to map cell - signaling pathways in heart muscle cells and immune cecell - signaling pathways in heart muscle cells and immusignaling pathways in heart muscle cells and immune cells.

Research from Rutgers Cancer Institute of New Jersey examining difficult to treat cancer tumors through genomic profiling shows that tumors with alterations in a signaling pathway responsible for cell regulation may respond to targeted therapy regardless of where the tumor originated in the body.

The Hedgehog signalling pathway is a good target for cancer researchers because it mainly switches back on in cancer cells and so blocking its function does not overly affect signalling in healthy cells.

In this study scientists used cells from the fruit fly Drosophila to screen for small molecules that suppress the signalling pathway central to the development of MPNs in humans.

Taken together, these results suggest that CSCs are essential for metastatic colonization and that CSCs induce stromal fibroblasts to secrete POSTN in the metastatic niche to support tumor cell outgrowth by augmenting the Wnt signaling pathway.

«Analysis of metastatic prostate cancers suggests treatment options: Study maps out abnormal signaling pathways in prostate cancer cells and provides computational approaches to identify individualized targets for therapy.»

The scientists then looked at gene activation in insulin signaling pathways for iPSCs and fibroblasts with IR mutations, and for corresponding cells derived from people without those mutations.

Dr. Kulkarni's research focuses on investigating signaling pathways impacting growth and function of pancreatic islet cells with the long - term goal of improving therapeutic approaches for the treatment of type 1 and type 2 diabetes and obesity - associated conditions.

A new study describes an improved protocol for the efficient differentiation of endothelial cells from pluripotent stem cell sources and highlights the importance of the MAPK and PI3K signaling pathways

Dr. Levitsky: My organization within Roche, Pharma Research and Early Development (pRED), has invested in antibody engineering, not only for use of monoclonal antibodies in the established ways of delivering cell - killing agents to tumors or interrupting cell signalling pathways, but also as ways to engage and manipulate the immune system's response to tumors.

In human cells, mebendazole suppressed the formation of the primary cilium, a microtubule - based organelle that functions as a signaling hub for Hh pathway activation.

Peggy Farnham is honored for her leadership and pioneering work analyzing transcriptional elements involved in regulation of cell - signaling pathways.

Here we show how second messengers relevant to the Gq signaling pathway can be detected in living cells using assays for DAG, PIP2, and Ca2 +.

Given the importance of G - protein signaling in cells, studies of downstream signaling pathways with the new Gα - blocking peptides are likely to reveal many new targets for future drugs, Sondek said.

This landmark revelation was the first definition of an entire cellular signaling pathway from the cell surface to the nucleus, providing an important paradigm for understanding intracellular signaling.

Crucial for all these processes is the correct operation of signaling pathways in cells and tissues.

Bacterial toxins are valuable molecular tools for elucidating signaling pathways in cells [53].

In addition, well - characterized expression profiles for melanoma cells have been identified that correlate highly proliferative cell states with increased expression for pathways regulated by the lineage - specific transcription factors SOX10 and MITF; conversely, migratory / invasive cell states have been correlated with TGFβ1 signaling pathways.

Together, these data revealed a functional link between the ABL kinases and TAZ signaling leading to increased AXL abundance in breast cancer cells, and identified a potentially druggable pathway for the treatment of breast cancer bone metastasis.

Taken together, our results provide for the first time the evidence of the biological significance of IRF - 9 / STAT2 complex, and furnish an alternative pathway modulating the expression of IFN - stimulated genes, contributing to the diversity of IFN signaling to mediate their multiple biological properties in normal and tumor cells.

We furnished here an alternative pathway for the diversity of IFN signaling to mediate its multiple biological properties in normal and tumor cells.

First, they used single - cell RNA sequencing to identify the signaling pathways critical for arterial endothelial cell differentiation.

The Ellerby lab is known for its pioneering studies on Huntington's disease (HD), and Karen is now using human stem cell models of HD to understand why important molecular signaling pathways, such as the TGF - β pathway, are dysregulated in HD.

These data support the hypothesis that ER - α plays an important role in the hypoxic CSC response in ER - α — positive cells and that signaling through this pathway is responsible, at least in part, for the increase in CSC.

For example, studies of cell signaling pathways in normal cells and cancer cells have contributed greatly to our knowledge about the disease, revealing molecular alterations that are shared among different types of cancer and pointing to possible strategies for treatmeFor example, studies of cell signaling pathways in normal cells and cancer cells have contributed greatly to our knowledge about the disease, revealing molecular alterations that are shared among different types of cancer and pointing to possible strategies for treatmefor treatment.

Specifically, we have generated clusters of transcripts that behave the same way under the entire spectrum of the sixty - seven experimental conditions; we have assembled genes in groups according to their time of expression during successive days of ES cell differentiation; we have included expression profiles of specific gene classes such as transcription regulatory factors and Expressed Sequence Tags; transcripts have been arranged in «Expression Waves» and juxtaposed to genes with opposite or complementary expression patterns; we have designed search engines to display the expression profile of any transcript during ES cell differentiation; gene expression data have been organized in animated graphs of KEGG signaling and metabolic pathways; and finally, we have incorporated advanced functional annotations for individual genes or gene clusters of interest and links to microarray and genomic resources.

For instance, the role of LIF - gp130 - Stat3 axis in promoting ES cell proliferation is particularly well - defined [1], [3], and BMP - induced differentiation signals are inhibited by a Nanog - Smad1 protein complex [4]; crosstalk between these pathways has also been reported [5].