Information theory analysis of
cell signaling reveals mechanisms for reliable cellular responses despite signal variability.
Not exact matches
Further study
revealed that these so - called immune proteins are actually present on the surface of certain nerve
cells, but that they functioned differently in the brain than they did in the rest of the body; rather than scouting for germs, they influenced
signals sent between neurons.
Weissman's research in mice had
revealed that cancer
cells produce large quantities of CD47, a protein that
signals immune
cells to spare the cancer
cells.
A team led by Carnegie's Wolf Frommer has
revealed how membrane proteins were networked with each other and with the
signaling proteins inside the
cell.
At the same time, the techniques of genetics and molecular biology began to
reveal the intricate biochemical
signals that synapses — the portals of nerve
cells — deploy during communication.
Mice without Del - 1 that had been induced to get EAE also had significantly higher numbers of inflammatory
cells in their spinal cords at the disease's peak, a fact that further experiments
revealed was due to increased levels of the
signaling molecule IL - 17.
Froemke says his team's latest findings
reveal that while mammals recognize sounds in the auditory cortex of their brains, the
signaling levels of nerve
cells in this brain region are simultaneously being strengthened or weakened in response to surrounding context.
The experiments
reveal that the sudden loss of energy supply to the heart
cells and the subsequent rapid «reboot» during treatment causes mitochondria to falter and trigger a whirlwind of aberrant electrical
signals.
Experimental studies have
revealed dozens of regulatory genes,
signaling proteins and other genetic tools that
cells use to gather information and communicate with one another.
The new study
revealed that pancreatic cancer
cells not only send
signals that make macrophages produce abnormal amounts of dectin - 1 surface receptors, but also that make tumor
cells themselves express high levels of galectin - 9.
Specifically, the data
reveal distinct transitions in factors that influence the different cellular states including
cell cycle regulators, transcription factors, and
signaling factors.
A better understanding of aberrant brain receptor
signaling that leads to nerve
cell dysfunction could
reveal a target for therapy, according to the authors.
The IBMC researchers (Porto University, Portugal)
reveal that the existence of specific
signals on microtubules — which work as intracellular highways — give directions to chromosomes of which route to take in the course of
cell division.
«Our research
revealed how small RNA molecules can work with other
cell signals called transcription factors to generate specific types of neurons, in this case motor neurons.
Electrophysiological recordings of these
cells after culture for about 15 weeks
revealed proper responses to currents and to inhibition of receptors needed for normal cerebellar
signaling, indicating that function had developed along with structure.
Reconstituted B
cell receptor
signaling reveals carbohydrate - dependent mode of activation.
Clara Franzini — Armstrong writes about Annemarie Weber, «a major contributor to the renaissance of muscle biology research in the 1950s to 1970s, when the components of the contractile machinery were identified; novel views of muscle contraction and regulation were elucidated; and principles of energy transduction, motility and intracellular
signaling common to all
cells were
revealed.»
But the new data
reveals that oRGs bring a support group with them: The
cells express genes for surface markers and molecular
signals that enhance their own ability to proliferate, the researchers found.
Flavio Donato's work has
revealed that, during development, stellate
cells in the medial entorhinal cortex are the source of an activity - dependent instructive
signal necessary for the maturation of those neurons that give us a sense of where we are.
A team of researchers from Whitehead Institute and the Howard Hughes Medical Institute has
revealed the structure of a key protein complex in humans that transmits
signals about nutrient levels, enabling
cells to align their...
Tobias Heckel (Hoflack, TUD)-- «
Revealing Src tyrosine kinase - dependent
signaling pathways in osteoclasts: Implications on actin organization and
cell polarity» (2008)
Endogenous optical
signals reveal changes of elastin and collagen organization during differentiation of mouse embryonic stem
cells.
Given the importance of G - protein
signaling in
cells, studies of downstream
signaling pathways with the new Gα - blocking peptides are likely to
reveal many new targets for future drugs, Sondek said.
Our recent analysis of SAC
signaling in C. elegans
revealed that there is a gradual increase in SAC strength during early embryogenesis, as
cells become smaller and smaller (1).
A transcriptome research of its organs
revealed its gene signature is highly evolved and adapted for extreme longevity (slow metabolism, improved insulin gene
signaling and glucose homeostasis, thus reduced blood glucose, improved cancer genes, improved endothelial function by eNOS (endothelial Nitric Oxide Synthase) meaning improved vascular coronary blood flow, improved microvasculature arterial and heart endothelium function) but more importantly, to answer your question, some whales display low blood glucose hypoglycemia, this affects the quantity and period of proteins / DNA /
cell exposure to glucose glycation, glycosylation and glycoxydation reactions.
Three US - based scientists - Thomas Südhof, of Stanford University School of Medicine, Richard Scheller, of the biotech company Genentech, and James Rothman, of Yale University - are the joint recipients of the neuroscience prize for their work to
reveal the precise molecular basis of the transfer of
signals between nerve
cells in the brain.
These techniques and functional analysis of the resulting data
revealed a number of up - and down - regulated proteins and mRNAs; i.e., up - regulated by a
signal (originating internal or external to the
cell) that results in increased expression of one or more genes and as a result the protein (s) encoded by those genes, and down - regulated by a process resulting in decreased gene and corresponding protein expression.
SAN FRANCISCO, CA — Researchers at the Gladstone Institute of Cardiovascular Disease (GICD) and the University of California, San Francisco have unraveled a complex
signaling process that
reveals how different types of
cells interact to create a heart.
Scientists
Reveal First Structure of a Class of Proteins that Sniff Out
Signals Guiding Blood
Cell Movement
Together, these data
revealed a functional link between the ABL kinases and TAZ
signaling leading to increased AXL abundance in breast cancer
cells, and identified a potentially druggable pathway for the treatment of breast cancer bone metastasis.
Working independently in different laboratories across the USA, Scheller, Südhof, and Rothman have
revealed in exquisite detail the molecules that govern the transfer of
signals from one nerve
cell to another at special connection points called synapses.
This work
revealed new roles for XBP - 1 in regulating
signal transduction through the B
cell receptor; in regulating the expression of important transcription factors in B
cells; in maintaining proper lipid synthesis and protein glycosylation in B
cells; and in colonization of stimulated B
cells into the bone marrow for sustention of antibody production.
Our study of annelid development
reveals a population of mesodermal
cells that converge and extend along the ventral midline and express a combination of transcription factors,
signaling molecules, and guidance factors that closely matches that of the vertebrate chordamesoderm.
By
revealing a novel but widespread
cell signaling process, the Sauer lab may have found a way to manipulate an important component of the immune system into more effectively fighting disease.
For example, studies of
cell signaling pathways in normal
cells and cancer
cells have contributed greatly to our knowledge about the disease,
revealing molecular alterations that are shared among different types of cancer and pointing to possible strategies for treatment.
Altogether, this study
reveals how a kinase integrates and transduces multiple
signals to control key
cell - cycle transitions during Plasmodium gametogenesis.
By
revealing a novel but widespread
cell signaling process, the scientists may have found a way to manipulate an important component of the immune system into more effectively fighting disease.
In a paper being published online today in the scientific journal
Cell Stem
Cell, Sheng Ding, PhD,
reveals efficient and robust methods for transforming adult skin
cells into neurons that are capable of transmitting brain
signals, marking one of the first documented experiments for transforming an adult human's skin
cells into functioning brain
cells.
There was no significant enrichment of genes in any functional category; however, GO annotations
revealed 34 DEGs involved in biological processes important to the establishment of pregnancy, such as «regulation of apoptosis,» «vasculature development,» «neurogenesis,» «positive regulation of
cell differentiation,» «Wnt receptor
signaling pathway,» and «gland development.»
Research now
reveals that luteolin has the ability to restrict the activity of the IGF and PI3K
cell signaling pathways necessary for the development of cancer found in cancer
cells of the colon.
Genetic analysis
revealed that Clostridia caused innate immune
cells to produce high levels of interleukin - 22 (IL - 22), a
signaling molecule known to decrease the permeability of the intestinal lining.
Tweets that mention Samsung Houdini
revealed on a video T Mobile News & Phone Reviews From
Cell Phone
Signal — Topsy.com on September 23rd, 2009 12:16 pm