Sentences with phrase «cell signalling events»

Her interests centre on developing methods for quantitative proteomics, phosphoproteomics and methods for tracking changes in sub-cellular localization of the proteome in response to cell signalling events.

Not exact matches

The brain uses the chemical to communicate between cells, and dopamine signals different events depending on its location.

Today, a team of researchers at Cold Spring Harbor Laboratory reports in the journal Genes & Development that they have arrived at «new insights into signaling events that underlie metastasis in ovarian cancer cells,» says Gaofeng Fan, Ph.D., postdoctoral investigator who conducted most of the experiments, in the laboratory of his mentor, CSHL Professor Nicholas K. Tonks.

They call this form of activation «non-ligand-dependent,» and in a complex series of biochemical and animal experiments, traced the pathway through which FER's binding to MET inside the cell sets off a cascade of cell - signaling events, all directly connected in prior research with cancer initiation, including RAC1 / PAK1 and SHP2 - ERK.

«There are signaling pathways that allow a cell to sense its environment and co-ordinate events to allow the cell to adapt to what's going on.

Researchers at the Medical University of South Carolina (MUSC) have identified one mechanism that regulates signaling events leading to cell migration and metastasis.

Cell receptors will receive a signal from outside, and when it binds, that information is transmitted through the receptor to other proteins within the cell, [creating] a chain of events to change how the gene works in the cCell receptors will receive a signal from outside, and when it binds, that information is transmitted through the receptor to other proteins within the cell, [creating] a chain of events to change how the gene works in the ccell, [creating] a chain of events to change how the gene works in the cellcell.

This was achieved via SCRIBE (Synthetic Cellular Recorders Integrating Biological Events), a programmable and modular architecture for generating single - stranded DNA (ssDNA) inside of living cells in response to gene regulatory signals.

That's the promise of a new study, which has found a unique set of signals in the immune cells of people who later developed inflammation, headaches, fevers, and other «adverse events» after receiving a flu shot.

To measure and compare concentrations, cells count stochastic binding events of signalling molecules that diffuse to cellular receptors.

After all, cancer cells rely heavily on SRCs to delicately orchestrate a wide range of cellular events, so SRC stimulation might be just as effective as SRC inhibition at disrupting the balance of signaling activity in cancer cells.

These findings show that regulation of retinoid metabolism and signaling is part of PPARγ - controlled events in these cells.

We also do culture of cells and tissues isolated from mice to manipulate signaling events in controlled, measurable ways.

How the vital processes of cell cycle control (with the final event of cytokinesis) and signalling for cell wall biosynthesis are exactly coordinated remains to be determined.

This binding triggers many biochemical signaling events that cause cells to proliferate and new blood vessels to develop, two hallmarks of cancer.

Role of initial protein phosphorylation events and localized release - activated calcium influx in B cell antigen receptor signaling.

Discovered a series of signaling events beginning with the morphogen Sonic hedgehog (Shh) that are essential for guiding a population of late cardiac progenitor cells in the outflow tract of the heart.

Recently, interest has developed regarding the possibility of targeting intracellular inhibitory proteins to improve T cell activity against cancer, including diacylglycerol kinase ζ (DGKζ)(9, 10) and Casitas b - lineage proto - oncogene b (Cbl - b)(11), which attenuate signal transduction events downstream of the TCR and CD28.

This work raises the possibility that histones can signal to non-histone proteins in human cells, and that deregulation of these events caused by MLL mutations might contribute to leukemia development.

It has been shown that JNK signaling plays a crucial role in this elimination; however, the initial event occurring at the interface between normal cells and polarity - deficient cells remained unknown.

Adherence of H. pylori to gastric epithelial cells is critical for induction of inflammation and injury; therefore, the overarching theme for our research has been delineation of the molecular signaling events initiated by bacterial: epithelial cell contact that regulate phenotypes related to carcinogenesis.

Like in the Wnt signaling pathway, ligands bind to the EGFR on the cell surface and initiate a cascade of events in the cell that in this case lead to regulation of genes that control cell cycle progression.

Our contributions to this field have helped to change the way endocytosis is perceived, from being simply a mechanism for signal attenuation to being a vital component of the cell signalling machinery that provides spatial and temporal dimensions to signalling events (1).

In response to extracellular matrix signalling, these cells undergo epithelialization and create an apical surface in contact with a cavity, a fundamental event for all subsequent development.

The Zeiss Cell Observer Spinning Disc acquires images at 30 frames per second, capturing high - speed biological events, such as calcium signaling, in real time.

Within this broad topic we are particularly interested in characterising (i) the molecular mechanism by which these photoreceptors mediate light - dependent entrainment of the circadian clock, (ii) the components mediating, in a light - quality - dependent fashion, nucleocytoplasmic partitioning of phytochromes and UVR8, (iii) how phosphorylation and sumoylation of these photorecepors and other signalling components modulate red / far - red and UVB - induced signalling, and (iv) to what extent intercellular and cell - autonomous events contribute to phytochrome and UVR8 regulated photomorphogenesis.

Saturated fat causes more of those toxic breakdown products and mitochondrial dysfunction, and increases oxidative stress, free radicals, and inflammation, establishing a vicious cycle of events in which saturated fat - induced free radicals cause dysfunction in the little power plants within our muscle cells, which causes an increase in free radical production and the impairment of insulin signaling.

For example, Dr. Greger discusses a» vicious cycle of events in which saturated fat induced free radicals causes dysfunction in the little powerplants within our muscle cells, which causes an increase in free production and impairment of insulin signaling.»

Linoleic acid induces proinflammatory events in vascular endothelial cells via activation of PI3K / Akt and ERK1 / 2 signaling

It didn't go well: spotty cell signals and overwhelmed servers turned the event into a disaster, and two dozen attendees launched a class action lawsuit to try and recoup travel expenses.