Sentences with phrase «cell signals switched»

The discovery could pave the way for new treatments that are able to block cell signals switched on in tumours with low levels of PTEN.

Not exact matches

Receptors are «molecular switches» — when a specific molecule binds to them, they change shape and send a signal to the cell to perform a certain function.

The UZH scientists have now discovered an astonishingly effective solution to switch off all signals emanating from HER2 in the cancer cells at the same time.

When dendritic cells not only signal myelin as a «target substance,» but also secrete the messenger substance IL - 6, a sort of molecular switch is flipped in the T cells.

GLP - 1 receptors are also found in the brain, and prior research has shown that activating them can boost the function of dopamine connections, act as an anti-inflammatory, improve energy production, and switch on cell survival signals.

The researchers found that Takinib inhibits an enzyme called TAK - 1, which serves as a switch controlling cell survival in the TNF - alpha signaling process.

When attractant or repellant chemicals attach themselves to receptor sites on the surface membrane of a bacterium, it triggers a process within the cell that leads to the modification of the signal protein, CheY (pronounced «Key - Y»), enabling it to bind to the switch and change the bacteria's direction of movement.

Using a pharmacogenetics approach, the researchers selectively switched off specific groups of brain cells — called neural ensembles — that react to select cues signaling either reward availability or reward omission.

For example, switches based on the optical force could be used to speed up the routing of light signals in fiber - optic cables, and optical oscillators could improve cell phone signal processing.

Measurements of the electrical activity of nerve cells in two key areas of the brain showed a surprising result: nerve cells in the prefrontal cortex signaled the distraction while it was being presented, but immediately restored the remembered information (the number of dots) once the distraction was switched off.

The trick was to use a new synthetic switch to confer light sensitivity on the retinal ganglion cells in these mice, which normally respond to signals from the rods and cones upstream of them.

In studies of cells, the team was surprised to learn that a family of ligands they had never considered as relevant to FOP, called activins, were switching on the mutant form of ACVR1; activins typically curb signaling by the normal receptor.

Instead of issuing orders to make mature macrophages switch roles, they filled the nerve bridge with a biological signal shown to attract younger, undifferentiated cells destined to become pro-healing macrophages.

Autoinducers (chemical signaling molecules that produce more of themselves inside the cell) control the switch that turns the light genes off and on.

The Hedgehog signalling pathway is a good target for cancer researchers because it mainly switches back on in cancer cells and so blocking its function does not overly affect signalling in healthy cells.

Originally, however, they were not examining brown fat thermogenesis, but instead were looking for clues to the function of ERRβ, a protein about which little was known at the time, except that it was closely related to ERRα, appeared in brown fat cells, and also worked as a so - called nuclear receptor — a molecular switch for gene activation that can be turned on by small lipophilic molecules or a signaling protein partner.

It sits on the DNA in a cell, controlling thousands of genes by switching them on or off in response to outside signals.

By analyzing a dataset of human immune cells stimulated with interferon — a signaling protein created in response to pathogens or tumor cells — the team could precisely identify which genes were switched on in each of 13 responding cell types.

That signal triggers another «off switch» that turns off reactive cells further along the allergic pathway.

A few years ago, Singh and colleagues identified a transcription factor called PU.1 that acts as the primary signal, a central genetic switch to initiate development of myeloid progenitor cells.

Phenylalanine pairs capable of forming a molecular switch are also present in many other signaling proteins, including receptors in human cells, making it an attractive target for drug design and biotechnology applications.

In the current issue of the journal Developmental Cell, the scientists show that the secret to this switch lies in the cells that surround the muscle cells, known as fibroblasts, which send signals that tell cardiomyocytes to divide or get bigger in size.

Prevailing theory did not consider this a problem: «it had PTEN bouncing around, all over the cell, and abundant enough so that it was always available near the membrane,» to switch a green growth signal back to red.

Then, after the signal is transmitted further into the cell's interior, it is time to switch the signal back to red.

Notch activity is antagonised by the cell fate determinant Numb, which asymmetrically partitions at mitosis and «switches off» Notch signalling in one of the daughter cells (7).

Imagine tagging along with a single protein molecule inside of a living cell as it goes about its job: relaying growth signals into the cell's nucleus, repairing damaged DNA, or switching on insulin production after a meal.

If brown fat is to be increased, the signals / messages for cell differentiation need to be switched from turning into muscle to turning into brown fat.

Nerve - signaling chemicals called neurotransmitters can «switch off» or dampen the activity of cells that signal arousal or relaxation.

Options: Radio: Am / Fm / Hd W / In - Dash Single Cd Graphic Equalizer 16 Speakers Radio Control Us Digital Signal Processor Window Grid Diversity Antenna Streaming Audio Audio Theft Deterrent Harman / Kardon Surround Sound System Regular Amplifier Radio W / Seek - Scan Compatible Remote Cd Mp3 Player Clock Speed Compensated Volume Control Aux Audio Input Jack Steering Wheel Controls Voice Activation Radio Data System Weatherband External Memory Control And 20 Gb Internal Memory Body - Colored Rear Bumper W / Chrome Bumper Insert Fully Automatic Aero - Composite Led Low / High Beam Auto - Leveling Directionally Adaptive Auto High - Beam Daytime Running Lights Preference Setting Headlamps W / Delay - Off Body - Colored Power Heated Side Mirrors W / Driver Auto Dimming And Power Folding Galvanized Steel / Aluminum Panels Speed Sensitive Rain Detecting Variable Intermittent Wipers W / Heated Jets Light Tinted Glass Power Open And Close Trunk Rear Cargo Access Chrome Grille Led Brakelights Rear Fog Lamps Chrome Bodyside Insert Express Open / Close Sliding And Tilting Glass 1St Row Sunroof W / Power Sunshade Fixed Rear Window W / Defroster And Power Blind Perimeter / Approach Lights Chrome Door Handles Clearcoat Paint Chrome Side Windows Trim Fixed Glass 2Nd Row Sunroof W / Power Sunshade Wheels W / Silver Accents Body - Colored Front Bumper W / Chrome Bumper Insert Tires: 245 / 45R19 Run - Flat As Wheels: 19 X 8.5 Double - Spoke Style 630 Door Auto - Latch Carpet Floor Trim And Carpet Trunk Lid / Rear Cargo Door Trim Cruise Control W / Steering Wheel Controls Power Door Locks W / Autolock Feature Driver And Passenger Visor Vanity Mirrors W / Driver And Passenger Illumination And Illuminated Rear Visor Mirror Leather Door Trim Insert Full Floor Console W / Locking Storage Mini Overhead Console And 4 12V Dc Power Outlets Trip Computer Head - Up Display Rear Hvac W / Separate Controls Remote Keyless Entry W / Integrated Key Transmitter 4 Door Curb / Courtesy Illuminated Entry Illuminated Ignition Switch And Panic Button Front And Rear Map Lights Delayed Accessory Power Front And Rear Cigar Lighter (S) Proximity Key For Doors And Push Button Start Power 1St Row Windows W / Front And Rear 1 - Touch Up / Down Hvac - Inc: Underseat Ducts Residual Heat Recirculation Auxiliary Rear Heater Headliner / Pillar Ducts And Console Ducts Cargo Space Lights Valet Function Day - Night Auto - Dimming Rearview Mirror Front Seats W / Leather Back Material And Power 4 - Way Driver Lumbar Trunk / Hatch Auto - Latch Instrument Panel Covered Bin Driver / Passenger And Rear Door Bins Smart Device Integration Sport Leather Steering Wheel W / Auto Tilt - Away Dual Zone Front And Rear Automatic Air Conditioning Rear Cupholder Driver Foot Rest Fade - To - Off Interior Lighting Interior Trim - Inc: Aluminum / Genuine Wood Instrument Panel Insert Aluminum / Genuine Wood Door Panel Insert Aluminum / Genuine Wood Console Insert And Metal - Look Interior Accents Redundant Digital Speedometer Systems Monitor Fob Controls - Inc: Trunk / Hatch / Tailgate Windows And Sunroof / Convertible Roof Front Cupholder Ashtray Tracker System Wifi Hotspot Mobile Hotspot Internet Access Power Fuel Flap Locking Type Remote Releases - Inc: Proximity Cargo Access Gauges - Inc: Speedometer Odometer Tachometer Oil Temperature Trip Odometer And Trip Computer Garage Door Transmitter Navigation System Cargo Area Concealed Storage Interior Lock Disable Bench Front Facing Rear Seat Heated Front Seats Illuminated Glove Box Power Rear Windows 4 - Wheel Disc Brakes W / 4 - Wheel Abs Front And Rear Vented Discs Brake Assist Hill Hold Control And Electric Parking Brake 2.81 Axle Ratio Electric Power - Assist Speed - Sensing Steering Engine Oil Cooler Dual Stainless Steel Exhaust W / Chrome Tailpipe Finisher Transmission: Sport Automatic Engine Auto Stop - Start Feature Multi-Link Rear Suspension W / Air Springs Engine: 4.4 L 32V Twin Turbocharged V8 Double Wishbone Front Suspension W / Air Springs 4 - Corner Auto - Leveling Suspension Gas - Pressurized Shock Absorbers Cell Phone Pre-Wiring 20.6 Gal.