Sentences with phrase «cell stage as»

All injections were performed at the 1 - cell stage as described previously (63).

Many reviewers agree with Bainbridge and Eldredge, dismissing Spore's Cell stage as a clone of the 1980s arcade game Pac - Man.

Not exact matches

The difficulties associated with obtaining nerve tissue at the correct stage of development and differentiation from aborted embryos means that foetal tissue transplantation is no longer in favour, but the creation of human embryos specifically as sources of stem cells, and the push to use «spare» embryos from IVF treatments is gatheringmomentum.

People in the audience were screaming (as if Hannah - Miley would enjoy their enthusiasm); they were singing along, dancing, waving their arms, their glow - sticks, and even lifting cell phones toward the stage, I mean screen.

It is just one more stage in the long, unbreaking chain of life that goes back to the first reproducing cell, and these implanted cells are not that special — they miscarry as much as they lead to developing into a fetus.

Challenging toys work those tiny brain cells as your kids reach new ages and stages.

Milk sodium concentration is a marker of tight junction closure between mammary epithelial cells; with the onset of secretory activation (stage II lactogenesis) milk sodium concentrations decrease sharply as potassium concentrations increase [14].

We found that: a) lactation stage must be defined biochemically (such as Na: K ratio), not by day of lactation, b) lactation stage influences RNA quality, quantity, and potential immune cell contamination, c) immediate processing and hard, fast centrifugation yield better quality RNA, and d) additional washing of the milk fat layer is not necessary for the analysis of mature milk samples and does not decrease immune cell contamination in colostrum samples.

They isolated blood cells from HIV - positive patients on antiretroviral therapy and at different stages of disease progression, as well as cells from non-infected individuals.

At this stage few were convinced of the link as the virus was not found in the cancerous cells themselves but in the surrounding tissue.

At this stage, as well as throughout the developmental process, sperm are tended to by Sertoli cells, which feed and support the growing sperm.

Scientists investigating the earliest stages of cancer development used an exquisitely sensitive sequencing method capable of detecting DNA mutations present in as few as 1.6 per cent of blood cells, to analyse 15 locations in the genome, which are known to be altered in leukemia.

As a result, cells could send chemical signals to each other without interference, setting the stage for complex organs to evolve.

DiChristina: It is, and then it moves on to a stage called the bloat stage, which lasts from the first week to about 3 weeks roughly, where those cellular processes continue and the gases that the cells create, as they continue their digesting and chemical processes, begin to build up in the body and the body starts to bloat.

Once stem cells can be grown and differentiated in a controlled way to replace degenerated cells and repair tissues, medical science may then be able to diagnose and cure many intractable diseases at their earliest stages, such as type 1 diabetes, Parkinson's disease, various cardiovascular diseases, liver disease, and cancer.

In humans it could potentially treat Type 1 diabetes in early stage patients, during what is known as the «honeymoon period,» when the pancreatic beta cells have not been completely destroyed and continue to secrete insulin.

«Many research groups are looking at how genes are regulated from the perspective of which genes need to be turned «on» for a cell to advance to the next stage of development, but now we see that it's just as important to know which genes need to be turned «off,»» Cook - Andersen said.

In Arabidopsis, as in most plants, there is a specific zone near the tip of the root where stem cells transition from a stage of proliferation to one where they differentiate into specific tissue types.

In a study being published in the journal Neuron, researchers show that the signal molecule TGF - beta acts as a time signal that regulates the nerve stem cells» potential at different stages of the brain's development — knowledge that may be significant for future pharmaceutical development.

«For example, we found that highly aggressive ovarian cancer cells are glutamine - dependent, and in our laboratory studies, we showed that depriving such cells of external sources of glutamine — as some experimental drugs do — was an effective way to kill late - stage cells.

This shows promise for breast cancer patients as diagnosing and treating the breast cancer at early stages means there is a greater chance of preventing cancer cells spreading to other tissues, such as the lungs, brain and bone.

The research, the team said, should not discourage the pursuit of experimental treatments but instead be heeded as a call to screen rigorously all cell lines for mutations at various stages of development as well as immediately before transplantation.

As explained by lead researcher, Dr Ferdinand von Meyenn, postdoctoral researcher in the Epigenetics research programme at the Babraham Institute and first author on the paper: «Our method establishes a reliable system that can be used to explore the early stages of epigenetic reprogramming in primordial germ cell - like cells and how this is regulated in the generation of reproductive cells.

The results show, for the first time, that the process of swapping genetic information, known as recombination, happens not when the malaria parasite is inside the mosquito, as previously thought, but during the asexual stage of the parasite's lifecycle inside human blood cells.

«We're interested in learning more about what other proteins LRP6 interacts with, as well as how it acts in different types of brain cells at different developmental stages of circuit development and refinement.»

In self - renewing tissues, such as the skin, chromatin modification is also involved in regulating the replacement of old or damaged cells in later stages in life.

After a certain period, some of these stem cells switch to producing neurons, a stage known as asymmetric division.

Salk scientists and colleagues have proposed new molecular criteria for judging just how close any line of laboratory - generated stem cells comes to mimicking embryonic cells seen in the very earliest stages of human development, known as naïve stem cells.

He held that the developing embryo reprised each stage of evolutionary progress, so that a human embryo started as a single - celled protist, then took the form of a fish, and so on through reptilian and mammalian stages of development.

Most excitingly, by comparing between individual cells, the team expect to reveal differences which could play key roles in both the early stages of life and the first stages of diseases such as cancer.

Because these cells are grouped in a loose, pebbly collection resembling a berry, this stage of the embryo is referred to as the morula (from the Latin for «little mulberry»).

The three stages of CD8 + T cell development are well known, but the current study identifies a detailed map of the regulatory circuitry, such as interactions between enhancers and promoters — genetic regulatory regions that function together in driving genes to transcribe proteins to carry out biological processes.

The single fertilized cell first divides into two cells (referred to as the 2 - cell stage of development).

The ability of a fertilized egg to generate both embryonic and extra-embryonic tissues is referred to as «totipotency,» an ultimate stem cell state seen only during the earliest stages of embryonic development.

One of the wonders of the mammalian embryo is that when it grows to the stage of a blastocyst, about 100 to 200 cells, a portion of the cells can be collected and maintained indefinitely as stem cells.

And as a possible treatment for late - stage cancer, researchers are trying to get the cancer cells to express miR - 34a again.

No matter where the source of their DNA, as soon as the embryos became hollow balls of cells, between the developmental stages known as blastocyst and morula, telomerase lengthened telomeres to the right size.

People in an acute stage of the disease often develop severe anemia, because the leukemia cells, which live almost ten times as long as their normal counterparts, replace healthy cells in the bone marrow.

They tracked the cells to the spleen, which serves as a staging area for immune cells.

It is generally believed that a series of mutations in multiple genes are needed for cancer cells to become metastatic; however, recent cancer stem cell theory, which still remains as a hypothesis, predicts that metastatic tumor cells are, by definition, cancer stem cells and that these cells may exist in tumor mass even at an early stage.

These organs serve as staging areas where immune cells get activated against disease and infection.

Wild - type ACVR1 mRNA (6 — 60 pg) at the 1 - cell stage fully (as in A) or partially rescued the mutant phenotype (C1 dorsalized; C).

Cells signaling disparity are in V1 (as shown by Pettigrew), but cells that extract illusory contours (from implied occlusion) are extracted in area V2, the next stage up, as shown by Rudiger von der Heydt of Johns Hopkins UniverCells signaling disparity are in V1 (as shown by Pettigrew), but cells that extract illusory contours (from implied occlusion) are extracted in area V2, the next stage up, as shown by Rudiger von der Heydt of Johns Hopkins Univercells that extract illusory contours (from implied occlusion) are extracted in area V2, the next stage up, as shown by Rudiger von der Heydt of Johns Hopkins University.

In a May 2014 study, Nagrath and colleagues found that highly aggressive ovarian cancer cells were glutamine - dependent and that depriving the cells of external sources of glutamine — as some experimental drugs do — was an effective way to kill late - stage ovarian cancer cells in the lab.

Using human fat - derived stem cells from young (aged 24 - 36 years), middle - aged (aged 48 - 55 years) and elderly (aged 60 - 81) participants, the team used ECIS to collect complex measurements during the growth and differentiation stages the hASC exhibited as they converted to bone cells.

ARandomized, Phase III, Double - Blind Placebo - Controlled Trial of Sunitinib as Maintenance Therapy in Non-Progressing Patients following an Initial Four Cycles of Platinum - Based Combination Chemotherapy in Advanced, Stage IIIB / IV Non-Small Cell Lung Cancer

ViaCyte's PEC - EncapTM (also known as VC - 01TM) product candidate is the first pluripotent stem cell - derived islet cell replacement therapy for the treatment of type 1 diabetes in clinical - stage development.

For more information regarding Bristol - Myers Squibb Clinical Trial participation, please visit www.BMSStudyConnect.com Inclusion Criteria: • Early stage IB - IIIA, operable non-small cell lung cancer, confirmed in tissue • Lung function capacity capable of tolerating the proposed lung surgery • Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 - 1 • Available tissue of primary lung tumor Exclusion Criteria: • Presence of locally advanced, inoperable or metastatic disease • Participants with active, known or suspected autoimmune disease • Prior treatment with any drug that targets T cell co-stimulations pathways (such as checkpoint inhibitors) Other protocol defined inclusion / exclusion criteria could apply

«Cancer cells by definition have high mutation rates and genomic instability even at the very earliest stages, so you could imagine building a virus that could destroy even the earliest lesions and be used as a prophylactic,» says O'Shea.

Inclusion Criteria: • Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 • Have histologically or cytologically confirmed advanced or metastatic non-small cell lung cancer (NSCLC)(Stage IIIb or greater) • Measurable disease, as defined by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 • Known PD - L1 tumor status as determined by an immunohistochemistry (IHC) assay performed by the central laboratory on tissue obtained at Screening • A woman of childbearing potential must have a negative highly sensitive serum (beta - human chorionic gonadotropin [beta - hCG]-RRB- at Screening within 14 days prior to study drug administration Inclusion Criteria for Crossover: • Participants must have been randomized to Arm A of the study and had radiographic disease progression according to RECIST 1.1 • Participants must have a mandatory biopsy at the time of disease progression according to RECIST 1.1 prior to crossing over.