Sentences with phrase «cell state»

Using now - standard techniques, they put those cells through a biological time machine, returning them to an embryo - like stem cell state.

To understand molecular forces behind different cell states in development, aging and disease, these scientists want to track the molecular make - up of human cells in time and space.

Protein synthesis is often directly related to a muscles cells state of hydration.

And importantly, avoiding a stem cell state allows the resulting motor neurons to retain the age of the original skin cells and, therefore, the age of the patient.

Until now, scientific dogma has stated that differentiation is a one - way path; once cells specialize, they can not return to the flexible stem - cell state on their own.

The key to developing this idea is to allow for a range of intermediate cell states between two extremes.

This form, known as the stem cell state, is the point at which blood cells may develop into any other type of cell in the body.

Cells in this ES cell state express low levels of PrEn markers such as Hex and maintain expression of some standard ES cell markers such as Oct4 and SSEA - 1.

His future studies will address fundamental questions relating to cell state transitions in pluripotent cells.

We also used it to study transition of mouse embryonic stem cells to a specific cell state of interest in Eckersley - Maslin et al Cell Reports 2016.

«We've not had cell surface markers for the different stem cell states before, which has made it hard to study them,» says Fredrik Lanner, assistant professor at Karolinska Institutet's Department of Clinical Science, Intervention and Technology.

Our general aim is to understand the reciprocal interactions between immune cell state / behavior and their environment -LSB-...]

Commitment in embryonic stem cells is often depicted as a binary choice between alternate cell states, pluripotency and specification to a particular germ layer or extraembryonic lineage.

Citation: Hough SR, Laslett AL, Grimmond SB, Kolle G, Pera MF (2009) A Continuum of Cell States Spans Pluripotency and Lineage Commitment in Human Embryonic Stem Cells.

Enzo Life Science's GFP - CERTIFIED Apoptosis / Necrosis Detection Kit detects four distinct cell states: viable cells, early apoptotic cells, late apoptotic cells, and necrotic cells.

The process involves the reversion of delta cells (which produce somatostatin, another pancreatic hormone) to a precursor - like cell state, with proliferation and later reconstitution of the populations of beta and delta cells.

The ability of a fertilized egg to generate both embryonic and extra-embryonic tissues is referred to as «totipotency,» an ultimate stem cell state seen only during the earliest stages of embryonic development.

In contrast to previously proposed forms of ANT that suggested deletion of genetic information as a means of preventing embryo formation, this new proposal actively instructs the adult nucleus to enter directly into an embryonic stem - cell state without passing through any intervening developmental stages.

hAMSCs can be coaxed into an even more robust stem - cell state using a Sendai virus to deliver key factors to the nucleus.

This finding — which also identifies a biomarker that can be used to gain a deeper understanding of the proteasome inhibitor - resistant state — is reported in the Proceedings of the National Academy of Sciences (PNAS) in an article entitled, Suppression of 19S proteasome subunits marks emergence of an altered cell state in diverse cancers.

Genetically reprogramming late - stage human cancer cells to a stem - cell state enabled them to force the reprogrammed cells to progress to an early cancerous state, revealing secreted blood biomarkers of early - stage disease along the way.

While the leader cell state is durable, followers will «spawn» new leaders after a month or two of growth in culture, Marcus says.

The «cell state splitter» model proposes that many stem cells turn into specific tissues in the body through waves of pulling and stretching as embryos.

Ecker, working closely with Jaenisch and other collaborators at Whitehead and the Ecole Polytechnique Federale de Lausanne, wanted to see whether these new techniques aiming to induce the naïve stem cell state truly did that.

All - Protein Mix Inducing adult cells to revert back to a stem cell state at first required the insertion of four genes, one of which was a cancer gene [see «Potent Alternative»; SciAm, February 2008].

The microscope image is of a colony of iNKT cells reprogrammed to the iPS cell state.

They artificially differ from normal two - cell state cells, however, and while possibly useful, their roles in research, such as models for embryo development, will need to be assessed.

Maintaining the stem cell state for many months in the lab does not reflect what happens during normal embryonic development where it exists only transiently.

A melanoma cell state distinction influences sensitivity to MAPK pathway inhibitors.

In a surprising finding that helps explain fundamental behaviors of normal and diseased cells, Whitehead Institute scientists have discovered a set of powerful gene regulators dubbed «super-enhancers» that control cell state and identity.

Cancer biologists have never seen such transitional cell states, but some are now seeking them in lab studies.

However, direct cellular reprogramming that does not involve a stem cell state solves some of the safety concerns surrounding the use of stem cells.

Taken together these data support the notion that the V+S + fraction represents an early state of PrEn differentiation that exists in equilibrium with other cell states present in ES cell cultures.

This early PrEn state does not appear to represent differentiation but rather exists in equilibrium with the Venus negative cell states.

Role of SAGA, a histone acetylase complex, in reprogramming fibroblasts to a stem cell state defined (4/15/15) A collaboration between Dr. Sharon Dent and Dr. Jeff Wrana at the Lunenfeld - Tanenbaum Research Institute, has shown that Myc drives expression of the SAGA component Gcn5.

Together, Myc and Gcn5, a histone acetyltransferase, reprogram fibroblasts to a stem cell state by activating an alternative splicing network.

Her current research is focused on discovering how normal and disease melanocyte cell states establish distinct regulatory DNA landscapes, and also determining how the combination of both genetic variation within these regulatory regions and environmental cell signals alter gene expression and normal cell function.

Taken together our data support a model in which ES cell culture has trapped a set of interconvertible cell states reminiscent of the early stages in blastocyst differentiation that may exist only transiently in the early embryo.

Johns Hopkins scientists have developed a reliable method to restore blood cells into a primitive stem cell state from which...

Here we use a transgenic allele designed to detect low level transcription in the primitive endoderm lineage as a tool to identify an immediate early endoderm - like ES cell state.

This workflow should be generalizable to predict single - cell state transitions in a cell population (normal or cancerous) subjected to perturbations.

Rather than reversing cells all the way back to a stem cell state before prompting them to turn into something else, such as in the case of iPS cells, the researchers «rewind» skin cells just enough to instruct them to form the more than 200 cell types that constitute the human body.

However, important hallmarks of immune cell states are often not detected in scRNA - seq experiments.

Lineage commitment in the mammalian embryo is most often depicted as a series of binary choices between alternate cell states, and increasing evidence supports the hypothesis that fate decisions in embryonic stem (ES) cell cultures reflect these developmental processes [1].