Sentences with phrase «cell state at»
All - Protein Mix Inducing adult cells to revert back to a stem cell state at first required the insertion of four genes, one of which was a cancer gene [see «Potent Alternative»; SciAm, February 2008].
https://www.scientificamerican.com/ Not exact matches
In a decision released by the Baltimore Circuit Court, Judge Martin P. Welch wrote that the 35 - year - old was being granted a new trial because his initial council failed to properly cross-examine an expert from the state about the reliability of cell tower data that seemed to place him at the scene of the crime.
Despite its poverty and isolation, North Korea has poured resources into a sophisticated cyber-warfare cell called Bureau 121, defectors from the secretive state said as Pyongyang came under the microscope for a crippling hack into computers at Sony Pictures Entertainment.
These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).
This statement is in sharp contrast to the statements of analysts at IHS Markit and GTM Research that new cell and module factories in the United States do not make economic sense despite the imposition of tariffs on imported modules.
Earlier in his career, Scott served as the founding Executive Vice President at Solar Cells, Inc. (now First Solar), the President of Glasstech Solar, Inc. (a manufacturer of semiconductor equipment for the solar industry), and consultant to venture capital firms and state agencies on renewable technologies and markets.
This week on Ride the Lightning: Tesla Motors Unofficial Podcast: «Tesla has officially begun battery cell production at the Gigafactory, one state...
Nanog is said to act at a later stage of development to keep cells in an undifferentiated state.
CNN: Sandusky's pastor addresses conviction from pulpit Jerry Sandusky sits in a county jail cell in Bellefonte, Pennsylvania, but his presence and the weight of the 45 guilty verdicts rendered against the former Penn State football coach on Friday night hung in the air Sunday morning at the State College church where he and his wife are longtime members.
In 2014, a team of researchers at UCLA led by genetics researcher, Steve Cole, discovered that the cells of people who experience chronic loneliness appear to be stuck in a state of fear.
By virtue of a complicated arrangement of cells in the brain, there is at the human level emergent a mental state marked by what I have styled awareness.
During cloning, the adult nucleus is converted to a totipotent state that will then proceed through a clear progression of developmental steps to yield pluripotent stem cells at a later time.
State College, Pennsylvania (CNN)-- Jerry Sandusky sits in a county jail cell in Bellefonte, Pennsylvania, but his presence and the weight of the 45 guilty verdicts rendered against the former Penn State football coach on Friday night hung in the air Sunday morning at the State College church where he and his wife are longtime members.
We can not stay where we are at present, either physically or psychically; but looking far ahead we may descry an ultimate state in which, organically associated with one another (more closely than the cells of a single brain) we shall form m our entirety a single system, ultra-complex and, in consequence, ultra-centrated....
They should have brought his dead - back to the states and buried it in a cell at Leavenworth.
The first page of Larsen's Human Embryology states that, `... [W] e begin our description of the developing human with the formation and differentiation of the male and female sex cells or gametes [sperm and egg], which will unite at fertilisation to initiate the embryonic development of a new individual».
... Researchers at Penn State University have found that three water soluble chemicals in garlic reduced cholesterol production in cultured rat liver cells by 40 - 60 percent.
He attended UC Berkley and Sonoma State University where he studied Cell Biology and worked at the USDA Plant Gene Expression Center.
I was sitting at a meeting and a colleague got a call on the cell - phone and mentioned the State building was on fire...
Take my teen's cell phone: He received it in 6th grade, which may be early or late depending on your beliefs / community / needs, but he was going out of state with a friend's family and I wanted him to be able to contact me (and me him) at any time.
More than 40 states require screening at birth for sickle cell anemia, along with other routine newborn screening tests.
All states require at least some newborn testing, like screening for PKU, sickle cell anemia, and other inherited conditions.
At 9 a.m., state legislators and survivors of solitary confinement unveil a replica solitary confinement cell and call for Gov. Andrew Cuomo to spend 24 hours in solitary confinement, Legislative Office Building, Albany.
Our Correspondent reports that a source said Jang was earlier kept in a cell at the State Criminal Investigations Department (CID) and police presence was beefed up around the area.
Off topic questions included his speech tomorrow to Britain's Labour Party, Chirlane McCray's attendance at an NYPD CompStat meeting, whether ISIS and the recent U.S. military strikes will cause a ramped - up security / counter-terrorism effort by the City, Governor Cuomo's efforts at supporting a Democratic state senate, Congressional approval of military strikes ordered by President Obama, the City school system's policy on student cell phones and continuing problems at Rikers Island.
The state senator's phone records show that he called Bonomo's cell phone at 10:42 a.m on Jan. 10, 2013.
And drones are not the only evidence of our expanding, and dangerous, surveillance state ***************** Congressional investigators have gotten, for the first, some data on how many law enforcement requests are made to the 9 major cell phone carriers for information on citizens.Hang on to your hats and bonnets, and sit down!It appears that there were at least 1.3 million cell - phone demands from law enforcement last year... and all without a court order.
You add to that that cell towers go down, you had satellite phones with us that couldn't reach a satellite signal, you've got to look at a way to get better communication between the local governments and the state and among the state.»
The right to organize, though apparently enshrined in the state constitution, does not apply to farmworkers Espada showed up at the farm on Friday and cell phoned the owner to berate him for the conditions on the farm and to tell him that the state was going to pass a law making his life more difficult.
Cell phones, smart phones, and other personal electronic devices are free from arbitrary police snooping in California — at least for the time being, thanks to actions taken by the state legislature and Governor Jerry Brown.
Last night, my State Governor, Dr. Abdulfatai Ahmed revealed to me an information at his disposal that a group of suspects who had been in police cells for several weeks for cultism and whose investigation had been concluded with prosecution about to commence under the State law based on the advice of the Director of Public Prosecution (DPP) and the Ministry of Justice were ordered to be transferred to Abuja this morning.
When Congressman Charlie Rangel whipped out his cell phone last night at a debate and began to chide his rivals in an imaginary conversation, State Senator Adriano Espaillat had one thought: this is wacky.
Solitary Watch estimates 80,000 to 100,000 incarcerated people are held in some form of isolated confinement at any time in the United States, most spending 23 or more hours a day in their cells.
In a companion paper in Analytical Biochemistry, the Singh laboratory and the Bernd Friebe laboratory at the Department of Plant Pathology, Kansas State University, describe a molecular tool to rapidly detect and analyze insertion of mitochondrial DNA into the genomes of cells.
«To our knowledge, we are the only research group to use sequential human biopsies to study CD8 + T cell function in situ, in their natural spatial distribution and at their original physiological state,» she said.
«Fat cells can adopt a range of metabolic phenotypes, depending on physiological conditions and location in the body,» said James G. Granneman, Ph.D., a researcher involved in the work from the Center for Integrative Metabolic and Endocrine Research at the Wayne State University School of Medicine in Detroit, MI.
According to Raymond Geor, an exercise physiologist at Michigan State University, sled dog muscle cells are well equipped to use this fat because they have a higher mitochondrial density — more cellular power plants — than other animals.
«There are currently no therapies which successfully reverse the damage seen in the more than 12,000 individuals who suffer a spinal cord injury each year in the United States alone,» says Dr. Richard G. Fessler, professor of neurological surgery at Rush University Medical Center and principal investigator for the Phase 1 clinical trial involving AST - OPC1 (oligodendrocyte progenitor cells).
Carlo Croce, a cancer researcher at Ohio State University in Columbus, and his colleagues created a diagram of interacting miRNAs for normal body cells by connecting them according to which genes they target and the function of those genes, in a way similar to analyses of human social networks.
Austad recalls one conversation in which Muller made an insightful connection about telomeres, the DNA - and - protein caps at the ends of chromosomes that shorten with every cell division, eventually pushing cells into a nondividing state called senescence.
A type of soil - dwelling bacterium produces molecules that induce death in melanoma cells, research at Oregon State University shows.
Led by researchers at the Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James), the retrospective study suggested that a pattern of molecules called microRNA (miRNA) in tumor cells might predict patients» response to radiation therapy.
An experimental drug in early development for aggressive brain tumors can cross the blood - brain tumor barrier, kill tumor cells and block the growth of tumor blood vessels, according to a study led by researchers at the Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James).
«By treating with chemotherapy, we're driving cells through a transition state and creating vulnerabilities,» said first author Aaron Goldman, PhD, a postdoctoral fellow in biomedical engineering at BWH.
«Some institutions [in the United States] are no longer recruiting junior - level faculty who don't have their own grant support,» says Michael Lehman, chair of the Department of Anatomy and Cell Biology at the University of Western Ontario and president - elect of the Association for Neuroscience Departments and Programs (ANDP).
A new study by researchers at The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James) has identified a mechanism by which cancer cells develop resistance to a class of drugs called fibroblast growth factor receptor (FGFR) inhibitors.
Researchers at Penn State have combined the two approaches by taking biodegradable polymer nanoparticles encapsulated with cancer - fighting drugs and incorporating them into immune cells to create a smart, targeted system to attack cancers of specific types.
In London last week at the World Conference of Science Journalists, Philip Hilts, the director of the Knight Science Journalism Program at M.I.T., reviewed the worldwide state of Internet and cell phone use, two of the major ways people now get news
«By learning how tau spreads, we may be able to stop it from jumping from neuron to neuron,» said Karen Duff, PhD, professor in the department of pathology and cell biology (in the Taub Institute for Research on Alzheimer's Disease and the Aging Brain) and professor of psychiatry (at New York State Psychiatric Institute.)
In a recent survey of epidemiologists and stem cell researchers in the United States, Japan, Germany, the United Kingdom, and France, nearly two - thirds said that they had been interviewed at least once in the past 3 years.