Sentences with phrase «cell state by»

Together, Myc and Gcn5, a histone acetyltransferase, reprogram fibroblasts to a stem cell state by activating an alternative splicing network.

Not exact matches

In a decision released by the Baltimore Circuit Court, Judge Martin P. Welch wrote that the 35 - year - old was being granted a new trial because his initial council failed to properly cross-examine an expert from the state about the reliability of cell tower data that seemed to place him at the scene of the crime.

The attacks were led by an Islamic State cell that was also responsible for the carnage in Paris in November 2015.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

In 2014, a team of researchers at UCLA led by genetics researcher, Steve Cole, discovered that the cells of people who experience chronic loneliness appear to be stuck in a state of fear.

Should the ANT - OAR proposal work, the alterations made to the adult nucleus will ensure that the cell produced by ANT - OAR enters immediately into a restricted, pluripotent state, without ever generating a totipotent embryo.

Indeed, the ability to clone animals, such as Dolly the sheep, by fusion of an adult cell to an enucleated oocyte demonstrates that the epigenetic programming responsible for maintaining an adult cell in a stable state can be erased by factors present in the cytoplasm of the oocyte.

By virtue of a complicated arrangement of cells in the brain, there is at the human level emergent a mental state marked by what I have styled awarenesBy virtue of a complicated arrangement of cells in the brain, there is at the human level emergent a mental state marked by what I have styled awarenesby what I have styled awareness.

The ultimate goal of our laboratory is to generate ES - like cells directly from somatic cells by nuclear reprogramming... which converts adult cells back into embryonic state.

Blending veggies down to a very fine liquid state extracts more nutrients by breaking down the cell walls.

... Researchers at Penn State University have found that three water soluble chemicals in garlic reduced cholesterol production in cultured rat liver cells by 40 - 60 percent.

Although most states require only a handful of tests, a panel of experts convened by the U.S. Department of Health and Human Services and the March of Dimes recommends newborns be screened for 30 genetic disorders, including hypothyroidism, cystic fibrosis, and sickle cell anemia.

In the case of ISIS and Twitter, imagine a retaliatory attack on a hacker cell that ends up killing civilians in large numbers by accident, creating international pressure against the U.S. bombing campaign against the Islamic State.

The reporter, Daily News Capitol Bureau Chief Ken Lovett, who has been covering state government for decades, was arrested by the State Police for talking on his cell phone in the lobby of the Capitol outside the state Senate, in violation of a Senate state government for decades, was arrested by the State Police for talking on his cell phone in the lobby of the Capitol outside the state Senate, in violation of a Senate State Police for talking on his cell phone in the lobby of the Capitol outside the state Senate, in violation of a Senate state Senate, in violation of a Senate rule.

Off topic questions included his speech tomorrow to Britain's Labour Party, Chirlane McCray's attendance at an NYPD CompStat meeting, whether ISIS and the recent U.S. military strikes will cause a ramped - up security / counter-terrorism effort by the City, Governor Cuomo's efforts at supporting a Democratic state senate, Congressional approval of military strikes ordered by President Obama, the City school system's policy on student cell phones and continuing problems at Rikers Island.

Sampling was conducted via a stratified dual frame probability sample provided by Survey Sampling International of landline and cell phone telephone numbers from within New York State weighted to reflect known population patterns.

Little said the Senate's plan also contains tax relief for North Country families and businesses, and rejects a number of «tax - and - fee increases» proposed by the governor, including new Department of Motor Vehicles fees, a surcharge on pre-paid cell phones and a proposal calling for online marketplaces to collect sales tax on behalf of their vendors, a loophole that governor says is costing state and local authorities $ 275 million in uncollected tax every year.

The Department of State Services has revealed plans by Boko Haram terrorist group to establish and operate sleeper cells whose (sole) mandates are to conduct surveillance and carry out subsequent attacks in the FCT.

Cell phones, smart phones, and other personal electronic devices are free from arbitrary police snooping in California — at least for the time being, thanks to actions taken by the state legislature and Governor Jerry Brown.

For decades, critics of the sprawling state prison system have assailed New York's policy of punishing convicts by consigning them to «Special Housing Units,» parking - space - sized cells where prisoners can remain isolated up to 23 hours a day.

The Chief of Army Staff, Lt Gen Tukur Yusufu Buratai has inaugurated the Multi — Cell box culvert linking Shema — Bakoshi — Matankari towns in Zuru local government Area of Kebbi State which was constructed by Army Engineers.

Eastern District Assistant United States Attorneys Lara Treinis Gatz and John Durham said in the letter that the strength of the government's case «is overwhelming and consists of dozens of witnesses... fully corroborated by numerous sources of evidence... including telephone call detail records, cell site records, photographs, financial records... and other documentary evidence.»

One of the latest twist of the story told on Wednesday was by Senate President Saraki who announced that his State governor and ally, Abdulfatai Ahmed had told him that a group of suspects who had been in police cells for several weeks for cultism and whose investigation had been concluded with prosecution about to commence under the State law based on the advice of the director of public prosecution (DPP) and the Ministry of Justice, were ordered to be transferred to Abuja on the directive of IGP) Idris Ibrahim.

By analysing the early steps that precede tumor formation, Alexandra Van Keymeulen and colleagues found that expression of oncogenic Pik3ca reactivates a multilineage differentiation program in adult stem cells that resembles to an immature embryonic state.

The grand plan envisioned by Ohio State University investigator Nicanor Moldovan and his colleagues entails sowing cells harvested from vessel lining, or endothelium, in silicon molds shaped like capillaries.

The most promising chemical — sulforaphane, a naturally occurring compound found in cruciferous vegetables — tamped down glucose production by liver cells growing in culture, and shifted liver gene expression away from a diseased state in diabetic rats.

Carlo Croce, a cancer researcher at Ohio State University in Columbus, and his colleagues created a diagram of interacting miRNAs for normal body cells by connecting them according to which genes they target and the function of those genes, in a way similar to analyses of human social networks.

Led by researchers at the Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James), the retrospective study suggested that a pattern of molecules called microRNA (miRNA) in tumor cells might predict patients» response to radiation therapy.

With the tumor in this vulnerable state, the researchers strike again by shutting down the cell's ability to mitigate the toxic stew it creates from its own deranged metabolism.

An experimental drug in early development for aggressive brain tumors can cross the blood - brain tumor barrier, kill tumor cells and block the growth of tumor blood vessels, according to a study led by researchers at the Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James).

«By treating with chemotherapy, we're driving cells through a transition state and creating vulnerabilities,» said first author Aaron Goldman, PhD, a postdoctoral fellow in biomedical engineering at BWH.

Honda global CEO Takanobu Ito said last week that Honda considers the FCEV «the ultimate environmentally responsible vehicle» and will launch an all - new fuel cell electric model in Japan, followed by the United States and Europe starting in 2015.

A new study by researchers at The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James) has identified a mechanism by which cancer cells develop resistance to a class of drugs called fibroblast growth factor receptor (FGFR) inhibitors.

Researchers at Penn State have combined the two approaches by taking biodegradable polymer nanoparticles encapsulated with cancer - fighting drugs and incorporating them into immune cells to create a smart, targeted system to attack cancers of specific types.

The new rules state that stem cells can be used if they are part of a study approved by the federal government, or if the protocol has been approved by an Institutional Review Board (IRB) that provides ethical review for research involving human volunteers.

«Our conclusion is that by pushing the mice into an extreme state and then bringing them back — by starving them and then feeding them again — the cells in the pancreas are triggered to use some kind of developmental reprogramming that rebuilds the part of the organ that's no longer functioning,» says senior author Valter Longo of the University of Southern California School of Gerontology and Director of the USC Longevity Institute.

«By learning how tau spreads, we may be able to stop it from jumping from neuron to neuron,» said Karen Duff, PhD, professor in the department of pathology and cell biology (in the Taub Institute for Research on Alzheimer's Disease and the Aging Brain) and professor of psychiatry (at New York State Psychiatric Institute.)

To create them, the skin cells need to be reprogrammed to an embryonic state by exposing them to extra amounts of four critical gene switches.

The postdoc, who did not want to be identified for fear of drawing unwanted attention, must now decide whether to continue with his work on stem cells — gambling that the U.S. government by summer will be inclined to grant him an extension — or spend the next half - year boning up on techniques that will help him secure a position outside the United States.

The continued marketing and use of experimental stem cell - based interventions inside and outside the United States is problematic and unsustainable, according to a new paper by science policy and bioethics experts at Rice University's Baker Institute for Public Policy and Wake Forest University.

Currently, most influenza vaccines in the United States are produced using chicken eggs, while a few are made in cell culture or by using recombinant DNA technologies.

Then the researchers, led by then - post-doc, now Oregon State University faculty member Matthew Robinson and colleagues, took biopsies from the volunteers» thigh muscles and compared the molecular makeup of their muscle cells to samples from sedentary volunteers.

Previously, researchers have produced hydrogen gas in microbial - powered, batterylike fuel cells, but only when they supplemented the energy produced by the bacteria with electrical energy from external sources — such as that obtained from renewable sources or burning fossil fuels, says Bruce Logan, an environmental engineer at Pennsylvania State University, University Park.

The authors used a time - lapse video recording coupled to single - cell molecular analyses to study the process step - by - step and found that fate decision is not a unique programmed event, but the result of a very dynamic process composed of spontaneous fluctuation and selective stabilisation of alternative cellular states.

In Europe and the United States, all kinds of cell preparations that are administered to patients following ex vivo culturing are classified as medicines, and monitored by drug agencies such as the US Food and Drug Administration, the European Medicines Agency and, in Italy, the Agenzia Italiana del Farmaco or AIFA.

They showed how ANG maintains stem cells by inducing a state of quiescence, or cellular dormancy, the first known evidence of ANG's suppressive activity.

The study was supported by a Science of Human Appearance Career Development Award from the Dermatology Foundation and by grants from the Medical Research Council of the UK, the Empire State Development's Division of Science, Technology and Innovation (NYSTAR), New York Stem Cell Science (NYSTEM), and the Biotechnology and Biological Sciences Research Council in the UK (BBSRC), as well as earlier support from the Steven and Michele Kirsch Foundation.

A study led by researchers at The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James) has identified an abnormal metabolic pathway that drives cancer - cell growth in a particular glioblastoma subtype.

Hydrogen is another attractive by - product of wastewater, and some of Logan's research at Penn State involves looking into how to capture hydrogen to run fuel cells.

The program is an opportunity for consumers in California, New York State and the District of Columbia to test about 100 of the company's Equinox sports utility vehicles powered by hydrogen fuel cells.