Genetically reprogramming late - stage human cancer cells to a stem -
cell state enabled them to force the reprogrammed cells to progress to an early cancerous state, revealing secreted blood biomarkers of early - stage disease along the way.
Not exact matches
Now, a team of scientists at the Icahn School of Medicine at Mount Sinai have developed the Just EGFP Death - Inducing T -
cell, or JEDI T -
cells, which
enable the visualization of T -
cell antigens, allowing researchers to study T -
cell interactions with different
cell types, model disease
states, and finally determine the functions of otherwise poorly characterized
cell populations.
«This in - depth characterization of individual beta
cells in different proliferative
states was
enabled by newer technology.
Work led by Dr. Blackwell is studying mechanisms that allow
cells to maintain a «pluripotent»
state that
enables them to become a variety of
cell types, including beta
cells.
By integrating the sequence data and the associated metadata, we have established laboratory and bioinformatics - based methods that
enable us to investigate scientific questions including: the tropism of ZIKV for dendritic
cells and the antiviral response of the
cells during infection (Bowen et al. 2017); investigating the phylogenetic diversity of strains obtained by Biodefense and Emerging Infections (BEI) Resources and distributed to virologists (manuscript in preparation); the genetic determinants of ZIKV host adaptation in C6 / 36 mosquito vs. Vero
cells; and the diversity of ZIKV circulating in limited geographic regions, including Barbados, Colombia, and the
state of Chiapas, Mexico.
In cancer, the new research indicates, FOXA1 activity
enables a
cell to return to a developmentally primitive
state — one in which the pancreas is being formed, and
cells are multiplying and moving around, assuming the positions that characterize the maturing organ.
Our technology is a highly specific and modular platform that
enables us to inhibit or «silence» the expression of disease - causing genes, allowing
cells to revert to their healthy
state.
The Innovator Award will
enable Sipkins to continue to combine
state - of - the - art imaging techniques, performed on living mice, with
cell and molecular biology approaches to learn more about these stem
cell niches.
An epigenetic factor reprograms gene enhancers,
enabling cancer
cells to «remember» an earlier developmental
state and causing metastasis.
Intel Atom Processor N450 1.66 GHz GMA 3150 integrated graphics with 2 GB RAM 2 GB 800 MHz DDR2 10 - inch multitouch screen with 1024 x 600 pixels resolution 64GB / 128GB / 256 GB / 512 GB solid
state drive 1.3 megapixel webcam 802.11 b / g / n WiFi Bluetooth B / G / N wireless Integrated 10/100 LAN 3G ready with optional 3G card Built - in HD Stereo Audio 2 Channel Stereo Speakers Omni - directional Microphone Micro SD Card Reader 2 Audio Jacks: Microphone - in, Speaker Out 2 USB Ports VGA adapter for an external monitor 4 -
cell battery
enabling up to 5 hours of operation features: Portable Bluetooth Wireless Keyboard with Track Pad, Custom Carry Case, Microfiber Cleaning Cloth, capacitive stylus pen, support HTML5 compatibility, Adobe Flash video
The exploitation of near - field energy transfer, solid -
state solvation, and phosphorescence
enables 10-fold increases in the power obtained from photovoltaic
cells, without the need for solar tracking.