Sentences with phrase «cell state seen»

The ability of a fertilized egg to generate both embryonic and extra-embryonic tissues is referred to as «totipotency,» an ultimate stem cell state seen only during the earliest stages of embryonic development.

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

One of the consequences of their work is stated in their press release: «With this first synthetic bacterial cell and the new tools and technologies we developed to successfully complete this project, we now have the means to dissect the genetic instruction set of a bacterial cell to see and understand how it really works.»

Jim Gerlach talking to himself: Let's see, I can run for an open, Executive Branch, Governors Seat or I as a member of the Republican Main Street Partnership who supports Stem - Cell Research, some LGBT Rights and Environmental Issues, where my primary opponent would be an ultra-right conservative who already ran another moderate GOP member to the Democratic party, and if I survived that bloody primary fight, would then face the six - term incumbent senator with long roots in the same part of the state as me and who had a 60 % approval rating among Pennsylvania Democrats before he decided to switch parties and will have a popular president campaigning for him in an already 55 - 45 Democratic state.

A longtime Albany reporter was arrested early Wednesday afternoon after he used his cell phone in the lobby of the New York State Senate — a move that gave birth to a hashtag movement and saw Gov. Andrew Cuomo step in to free him.

But whether the state is moving to view the non-violent drug user as a victim of an epidemic rather than someone who belongs in a holding cell remains to be seen.

«There are currently no therapies which successfully reverse the damage seen in the more than 12,000 individuals who suffer a spinal cord injury each year in the United States alone,» says Dr. Richard G. Fessler, professor of neurological surgery at Rush University Medical Center and principal investigator for the Phase 1 clinical trial involving AST - OPC1 (oligodendrocyte progenitor cells).

«I routinely see where individual stem cell centers in the United States receive donations from some high - net - worth individuals in the range of $ 50 million — you don't see that happening routinely here in the UK,» says KCL's Minger, an American who moved to the UK about 13 years ago.

Researchers have found that when properly enticed, some types of specialized human cells can revert to a more nascent state (see p. 85).

The drug had no effect on the epigenetic state of DNA taken from the local metastasis but reversed the epigenetic changes seen in cells from the distant metastasis.

The scientists speculated that when chromosome tips get too stubby — a process that can be reversed by telomerase, an enzyme made up of protein and RNA — cells cease replicating and enter a state called senescence (see» More Than a Sum of Our Cells&raqcells cease replicating and enter a state called senescence (see» More Than a Sum of Our Cells&raqCells»).

Rattan joined the Clark group in 1984 and started exploring what happens when skin, bone, and connective tissue cells grow old and enter a state of limbo — called senescence — in which they neither divide nor die (see «More Than a Sum of Our Cells&raqcells grow old and enter a state of limbo — called senescence — in which they neither divide nor die (see «More Than a Sum of Our Cells&raqCells»).

All - Protein Mix Inducing adult cells to revert back to a stem cell state at first required the insertion of four genes, one of which was a cancer gene [see «Potent Alternative»; SciAm, February 2008].

«This really was a comparison of existing methods, applying the same criteria to each method and seeing where each cell state is,» says Ecker.

To see how courting is affected when neurons are hyperactivated, they used flies with a version of a gene that was stuck in the «on» state in clumps of nerve cells.

Previous reports examining the kinetics of cell division in H - 2Kb - tsA58 - derived cell lines have determined that the cessation of cell division seen at nonpermissive conditions directly correlates with the steady - state decline in large T antigen protein (25).

In cancer, a state marked by increased protein translation and biomass expansion, HSF1 is activated and binds to numerous genes throughout the genome, as seen in the heat map of HSF1 ChIP - Seq read density in M0 - 91acute myeloid leukemia cells (DMSO, far left).

Lipton went on to state, «It will be important to see if HIV / AIDS acts similarly on stem cells for other organs in the human body, as this may impact on the disease process as a whole.»

We can even engineer glioma genes into normal cells to see how they operate, and vice versa — we can try and «fix» the damaged glioma genes in patient's cells in the dish and see if this brings them back to a normal state.

The asymmetry of the Vj response of these UNC - 7: UNC - 9 heterotypic channels was not restricted to the steady state response of these cells, but also was seen in the rectifying nature of the initial conductance that increases as the UNC - 9 cell becomes more positive.

He and most other researchers no longer use this technique, but Yamanaka did genetically tweak the cells to visibly see when they had reverted to an embryonic - like state.

The epiblast stem cells on top have begun to differentiate, but when treated with the drug, they revert to an»em bryonic» - like state, as seen at bottom.

Isoleucine can be seen as the BCAA which mediates glucose uptake (into a cell) and breakdown (into energy) to a larger degree than other amino acids and may serve a role as a hypoglycemic (in diabetics) or as a performance enhancer (if taken preworkout in a carbohydrate replete state).

Middleburg High School in Middleburg, Florida, has seen its cell phone policy change twice in three years as the state laws eased.

The report from Autocar states that we could see the fuel cell vehicle debut at the Frankfurt Motor Show in fall of 2017, with sales possibly starting as early as 2018.

He's also stated that we can expect to see Splinter Cell Conviction on the PS3 within the year.

It was also the exhibition that confirmed Richter's status as one of the leading artists in the world, and was described by Storr in his introduction as «long overdue» in the United States.2 In 2003 Richter embarked on a small but substantially sized series of paintings entitled Silicate [CR: 885/1 -4] inspired by an article in the Frankfurter Allgemeine Zeitung from 12 March 2003 about the shimmering qualities of certain insects» bodies.3 The resulting four large paintings are perhaps the most overtly biological of the abstract works in Richter's oeuvre, suggestive of cell formations and genetic sequences seen under the microscope.

We're well familiar with GotWind around here, and it's great to see them head to the states to help LG create the first renewable energy charging tent a US cell phone provider has ever put up in the states.

At the time of the speech, hybrid - electric cars, which offer higher fuel efficiency than regular cars because of electric motors that help drive the wheels, were seen in the United States as but a minor detour or way station en route to a world of hydrogen fuel cells.

Currently available proxy data are equivocal concerning a possible increase in the intensity of the meridional overturning cell for either transient or equilibrium climate states during the Pliocene, although an increase would contrast with the North Atlantic transient deep - water production decreases that are found in most coupled model simulations for the 21st century (see Chapter 10).

Koenig states that she sees the barrel as a platform for future designs — from adding filtration and drip irrigation kits, to adding a cell phone charger that uses the rotation of the wheel to generate electricity for a full battery.

We see disproportionately high numbers of men and women held in police cells, incarcerated in gaols, and significant numbers passing away from violence, illness or a combination of both while detained by the state this year.