Sentences with phrase «cell state transitions»

This workflow should be generalizable to predict single - cell state transitions in a cell population (normal or cancerous) subjected to perturbations.

His future studies will address fundamental questions relating to cell state transitions in pluripotent cells.

Not exact matches

«By treating with chemotherapy, we're driving cells through a transition state and creating vulnerabilities,» said first author Aaron Goldman, PhD, a postdoctoral fellow in biomedical engineering at BWH.

In a continuation of this work, Goldman is also using mathematical modeling to pursue the most effective dose of chemotherapy to induce the vulnerable transition state of the cancer cell demonstrated in this research.

The current finding, Gladfelter says, «helps us understand how the right components get recruited to droplets so cells can potentially avoid this transition to an aberrant, solid state.»

Specifically, the data reveal distinct transitions in factors that influence the different cellular states including cell cycle regulators, transcription factors, and signaling factors.

The findings may help scientists to better understand the earliest epigenetic changes which can initiate abnormal cell processes, and the transition between the pre-disease state and cancer.

«This observation, combined with the transcriptomic data, told us that cells transition through an intermediate state before becoming 2 - cell - like cells» said Maria Elena Torres - Padilla.

Much like inert granular matter, these cells interacted with their nearest neighbors to form a «disordered collective» that transitioned between solid - like and fluid - like states.

Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits.

Researchers at the Université libre de Bruxelles, ULB define for the first time the tumor transition states occurring during cancer progression and identify the tumor cell populations responsible for metastasis.

Intracellular pH homeostasis during cell - cycle progression and growth state transition in Schizosaccharomyces pombe.

According to this model, differentiation is a gradual transition from an open and permissive chromatin state in multipotent stem cells to a compacted cell - type specific chromatin state in differentiated cells.

Stomach cells transitioning from a mature to a stem cell - like state.

Critical transitions across states and tipping points lay at the heart of most complex problems in modern biology, including reversible physiological adaptation to environmental change, evolution of interactions in the microbial loop, development of an adult body plan from an embryo, differentiation of a stem cell, and transition from health to disease.

A phase transition between jammed and unjammed states could fluidize and mobilize tumor cells as a group, without requiring them to transform from one cell type to a drastically different one, Friedl said.

This study, published in Science, will help researchers understand why and how stem cells transition through states of differentiation through their different molecular properties.

In this way embryo - derived stem cell lines and ES cell differentiation may be providing access to potential «transition states,» required for lineage specification in vivo.

We also used it to study transition of mouse embryonic stem cells to a specific cell state of interest in Eckersley - Maslin et al Cell Reports 2cell state of interest in Eckersley - Maslin et al Cell Reports 2Cell Reports 2016.

A more recent study showed overlapping expression of nanog with GATA - 6 and a Pdgfra reporter, markers of the primitive endoderm lineage, from the morula to the 64 cell stages [8], suggesting a gradual transition from a pluripotency program to a committed state.

Within the population of transcriptionally similar stem and progenitor cells, our analysis reveals considerable cell - to - cell differences in their probability to transition to another committed state.

A. Fehér, T.P. Pasternak, D. Dudits, Transition of somatic plant cells to an embryogenic state.

Only those cells with a flexible genome, honed through millions of years of environmental forcing and variability selection, can transition from one energy state to another.

We believe that this 10 - lipid phospholipid biomarker panel reflects the breakdown of neural cell membranes in those individuals destined to develop advanced moderate cognitive impairment or Alzheimer's disease and may mark the transition between preclinical states where synaptic dysfunction and early neurodegeneration give rise to subtle cognitive changes.»

«A series of cloud - resolving simulations shows that the transition between closed and open cellular states is asymmetrical and characterized by a rapid («runaway») transition from the closed - to the opencell state but slower recovery to the closed - cell state.

Create Resume Lyla Wells 100 Main Street, Cityplace, CA, 91019 Home: [phone] Cell: [phone] [email protected] Professional Summary Decorated military professional transitioning from the United States Air Force to a career in law enforcement.

First, transitions (emotional switching) assessed the number of dyadic changes per minute between cells on the state space grid, and it was corrected for differences in total duration of the discussions.