Sentences with phrase «cell subset in»

In this review, after a summary on the known innate CD8 (+) T - cell features in the mouse, we propose Eomes together with KIR / NKG2A and CD49d as a signature to standardize the identification of this innate CD8 (+) T - cell subset in humans.

We recently reported that CD8 (+) T cells responding to innate - like IL - 12 + IL - 18 stimulation and co-expressing the transcription factor Eomesodermin (Eomes) and KIR / NKG2A membrane receptors with a memory / EMRA phenotype may represent a new, functionally distinct innate T cell subset in humans.

«Over the past ten years, several research groups, including our own, have shown the importance of certain immune cell subsets in preventing or exacerbating heart disease in mice, but we are just beginning to understand how the metabolism and function of these immune cells change during cardiovascular disease progression in humans,» says Hedrick.

Prof. Caccamo's research is focused on the role of human T cell subsets in physiology and in pathology, on the role of human T lymphocytes during M. tuberculosis infection and on the identification, optimization and evaluation of correlates of protection and tuberculosis disease.

During her doctoral studies, Sasha investigated primary human immunodeficiencies, lymphocyte cell death and metabolic pathways as well as memory T cell subsets in the laboratory of Dr. Andrew Snow.

We used SLA to detect the nuclear import of transcription factors across cell subsets in complex samples.

Not exact matches

Previous approaches were only marginally effective as they reached one set of hair cells in the inner ear, but another subset — equally critical for hearing — remained largely impenetrable.

In contrast, the cancer cells often had subsets of miRNAs that were not connected to the rest of the network — rogue groups that had broken free.

Research from past studies found that most tumor cells remain in the primary breast site, but a subset of cells leaves the breast and enters the bloodstream.

That shift can lead to «an environment that is conducive to T - cell replication that results in amplification of subsets of viral populations and creation of genetically distinct, compartmentalized viral populations,» they explained.

While most fat cells in the human body store energy, everyone has a small subset of brown fat cells that do the opposite — burn energy and generate heat.

«What was especially surprising and exciting was that a subset of nerve cells situated largely in the brainstem could slowly re-grow far down the spinal cord once a permissive environment that allowed them past the site of the scar was provided,» Silver said.

A subset of the implanted human stem cells matured into rotund, humanlike astrocytes in the animals» brains, taking over operations from the native mouse astrocytes.

In the failing heart, they found increased CD8 + and CD4 + T - cells, and increased Th1, Th2, Th17 and Treg CD4 + subsets.

For the subset of more recent patients, the researchers assessed tumor cell behavior — in particular, cancer cells» ability to cross the endothelium (inner layer) of blood vessels.

In particular, they found significant expansion of CD3 + CD8 + cytotoxic T - cells and CD3 + CD4 + helper T - cells in circulating blood, as well as increased CD4 + subsets of Th1, Th2, Th17 and Treg cells, indicating a pro-inflammatory responsIn particular, they found significant expansion of CD3 + CD8 + cytotoxic T - cells and CD3 + CD4 + helper T - cells in circulating blood, as well as increased CD4 + subsets of Th1, Th2, Th17 and Treg cells, indicating a pro-inflammatory responsin circulating blood, as well as increased CD4 + subsets of Th1, Th2, Th17 and Treg cells, indicating a pro-inflammatory response.

It indicates that the interaction with mitochondria is driven by Toxoplasma, rather than the host cell, and it is likely something the parasite does «to enable survival in some particular subset of hosts,» he says.

So the UAB researchers began to look for changes in subsets of T - cells over an eight - week period after heart attack.

Frey and his colleagues made use of mathematical models to analyze the complex interplay between ecological factors and population dynamics, and were able to demonstrate that populations can indeed respond in a coordinated fashion to chemical information even when the signal molecules are generated by only a subset of the cells.

Some of the first evidence for cancer stem cells came from studies of leukemia in the 1990s, which showed that only a small subset of the cancerous blood cells could propagate the disease in mice.

Using this test, the team found that genetically - intact HIV hides in specific subsets of CD4 + T - cells.

We identified distinct clusters of CD4 - CTL effector and precursor cells in the TEMRA subset; the precursor cells shared TCR clonotypes with CD4 - CTL effectors and were distinguished by high expression of the interleukin - 7 receptor.

However, little is known in humans about the biology of CD4 - CTL generation, their functional properties, and heterogeneity, especially in relation to other well - described CD4 + memory T cell subsets.

Then, Saper and colleagues focused on a subset of neurons — called PBelCGRP cells - known to show activity in response to elevated CO2 levels.

Single - cell differential gene expression analysis revealed a spectrum of known transcripts, including several linked to cytotoxic and costimulatory function that are expressed at higher levels in the TEMRA (effector memory T cells expressing CD45RA) subset, which is highly enriched for CD4 - CTLs, compared with CD4 + T cells in the central memory (TCM) and effector memory (TEM) subsets.

Simultaneous T cell antigen receptor (TCR) analysis in single cells and bulk subsets revealed that CD4 - TEMRA cells show marked clonal expansion compared with TCM and TEM cells and that most of CD4 - TEMRA were dengue virus (DENV)-- specific in donors with previous DENV infection.

Monitoring immune cell activity — including phenotyping immune cell subsets, tracking cell proliferation, and measuring cytokine production — can provide insights into the overall status of immune function in patients, particularly those undergoing immunosuppression after transplants, enduring cancer treatment, or suffering from autoimmune disease or other pathologies that affect the immune system.

Beginning in 2000, the researchers began to collect and store blood cells from a subset of these children.

These efforts are now turning up evidence that a sizable subset of childhood cancers are rooted in inherited genes, or mutations so soon after conception that they pervade every cell.

The team, which included members of the Health Science Center departments of medicine and biochemistry, investigators from the UT Southwestern Medical Center at Dallas and a group of collaborators from Austria, found that the gene that codes the enzyme D2 - hydroxyglutarate dehydrogenase (D2HGDH) is mutated in a subset of cancers called diffuse large B - cell lymphomas.

In order for these unspecialized cells to acquire the characteristics that make a leaf cell different from a root cell or a blood cell different from a muscle cell, they must turn on different subsets of genes to produce the proteins responsible for each cell type's distinctive properties.

Using genetic tools to establish in which cells cancer - driving mutations originated and then propagated into other cancer cells, they demonstrated that a distinct and rare subset of MDS cells showed all the hallmarks of cancer stem cells, and that no other malignant MDS cells were able to propagate the tumour.

In layer 2, the density of cartridges arising from a transcriptionally - unique subset of chandelier cells containing calbindin was nearly 3-fold higher in the schizophrenia grouIn layer 2, the density of cartridges arising from a transcriptionally - unique subset of chandelier cells containing calbindin was nearly 3-fold higher in the schizophrenia grouin the schizophrenia group.

In the gut, a special subset of Treg cells, called peripheral Treg (pTreg) cells, exists in both the small and large intestinIn the gut, a special subset of Treg cells, called peripheral Treg (pTreg) cells, exists in both the small and large intestinin both the small and large intestine.

In normal mice, these neurons — a subset of nerve cells that release the neurotransmitter gamma - amino butyric acid (GABA), and so are called GABAergic neurons — are most active during waking periods when the mice are eating or grooming, two highly pleasurable activities.

The IL - 2 receptor α subunit, CD25 is commonly expressed in T - regulatory (Treg) cells and a small subset of Reed - Sternberg cells in Hodgkin's Lymphoma (HL).

Although it is among the most highly metastatic of all cancers, multiple myeloma is driven to spread by only a subset of the myeloma cells within a patient's body, researchers at Dana - Farber Cancer Institute have found in a study presented at the annual meeting of the American Society of Hematology (ASH).

By cloning rat melanopsin and generating specific antibodies, we show that melanopsin is present in cell bodies, dendrites, and proximal axonal segments of a subset of rat RGCs.

«The collapse of the CD4 + T - cell system is the cardinal feature of AIDS,» Goldsmith observes, «so understanding which subsets of T cells can be infected is important in providing a clear picture of how HIV reduces the number of T cells.»

- In a study with potentially major implications for the future treatment of autoimmunity and related conditions, scientists from the Perelman School of Medicine at the University of Pennsylvania have found a way to remove the subset of antibody - making cells that cause an autoimmune disease, without harming the rest of the immune system.

Now, researchers have found that a very small subset of anti-viral immune cells, transplanted along with a donor's blood stem cells, could be enough to fight and even prevent the disease caused by CMV, in research conducted in mice and published Jan 16th in the Journal of Immunology.

Lee and Cate's research hints that this secret lever, which triggers translation of only a special subset of mRNAs — perhaps only 500 out of some 10,000 mRNAs produced by a cell — will be found to play a critical role in other diseases besides cancer, as well as in plants and animals.

Overall, including all genomic variations present in most if not all tumor cells (clonal) as well as those present only in subsets of the cancer cells (subclonal) from tumor tissue, the researchers detected a total of 864 genetic changes in tissue samples across the three tumor types, and 627 (73 %) of those were also found in the blood.

First, researchers found a pigment called melanopsin in a small subset of retinal ganglion cells (RGCs) in the eyes of rats.

Now, the Martin team has found a subset of cells, squeezed in between the main LGN layers in marmoset monkeys that fire in response to inputs from both eyes.

Additional experiments with transgenic mice indicated that L1 had hopscotched in a subset of brain cells, but not in the cells of most other tissues.

They hope to identify the complete set of DNA binding sites and corresponding target genes for the regulons in embryonic stem cells and a subset of the cells they differentiate into.

Dr Peter Rugg - Gunn, group leader in the Babraham Institute's Epigenetics research programme and a senior co-author on the paper, explains: «One of the exciting aspects of this study is that we were able to capture naïve stem cells at a very early stage of their reprogramming — these early cells had switched on a subset of naïve - specific genes, but they had not yet fully matured.

In the cells of humans and other organisms, only a subset of genes are active at any given time, depending largely on the stage of life and the particular duties of the cell.

When a subset of cells in the circuit is switched on, mice immediately begin drinking water, even if they are fully hydrated.