Analyzing data from thousands of cancer lines and tumors, the researchers found that those demonstrating resistance to proteasome inhibitor drugs were
marked by suppressed expression of one or more of the
cells» proteasome cap subunits (which are a
subsets of the larger proteasome).
Simultaneous T
cell antigen receptor (TCR) analysis in single
cells and bulk
subsets revealed that CD4 - TEMRA
cells show
marked clonal expansion compared with TCM and TEM
cells and that most of CD4 - TEMRA were dengue virus (DENV)-- specific in donors with previous DENV infection.