Sentences with phrase «cell subset well»

Not exact matches

In particular, they found significant expansion of CD3 + CD8 + cytotoxic T - cells and CD3 + CD4 + helper T - cells in circulating blood, as well as increased CD4 + subsets of Th1, Th2, Th17 and Treg cells, indicating a pro-inflammatory response.

«Our data suggests that targeting specific immune cell subsets at defined stages of disease may represent a better approach to therapeutic immunomodulation to improve heart failure.»

However, little is known in humans about the biology of CD4 - CTL generation, their functional properties, and heterogeneity, especially in relation to other well - described CD4 + memory T cell subsets.

While the simple proteins called histatins are well known for their ability to ward off infections, biochemist Menno Oudhoff of the University of Amsterdam discovered a subset of histatins that also prompt cells from the skin's surface, called the epithelium, to close over a wound.

The treatment with the engineered immune cells, called CAR - T cell therapy, may work even better if doctors transplant a subset of immune cells known as memory T cells, researchers reported February 14...

Lee and Cate's research hints that this secret lever, which triggers translation of only a special subset of mRNAs — perhaps only 500 out of some 10,000 mRNAs produced by a cell — will be found to play a critical role in other diseases besides cancer, as well as in plants and animals.

Overall, including all genomic variations present in most if not all tumor cells (clonal) as well as those present only in subsets of the cancer cells (subclonal) from tumor tissue, the researchers detected a total of 864 genetic changes in tissue samples across the three tumor types, and 627 (73 %) of those were also found in the blood.

One of these T cell subsets is comprised of the CD1d - reactive invariant natural killer T cells, and over the years we have studied the development, homeostasis, activation and regulation of function of these cells, as well as their specificity and the pathways leading to the processing and presentation of antigens by CD1d.

These studies have given us a better understanding of the genes that influence the development of these cells, and in particular, to characterize the differences between subsets of Vα14i NKT cells with distinct functional properties.

Systemic vs. mucosal immunisation regimens will be compared for optimal induction of innate and adaptive immune cell subsets, including Th1, Th2, Th17, Th22 and regulatory T cells, as well as inflammation genes.

Scientists from the Sundrud lab have identified a normally small subset of immune cells that may play a major role in the development of Crohn's disease as well as steroid resistance associated with the disease.

During her doctoral studies, Sasha investigated primary human immunodeficiencies, lymphocyte cell death and metabolic pathways as well as memory T cell subsets in the laboratory of Dr. Andrew Snow.

T - cell subsets as well as the inflammatory markers IL - 6, IL - 10, C - reactive protein, transthyretin and albumin were evaluated.

In their latest study, published in the Nov. 2, 2015, advance online issue of Nature Immunology, researchers at the La Jolla Institute for Allergy and Immunology report that these disease - causing autoimmune T cells are lured into the nervous system by monocytes and macrophages, a subset of immune cells better known as the immune system's cleanup crew.

Similarly, microarray analyses comparing global gene expression in cells that overexpress wild - type STAT3 or phosphorylation - deficient mutant indicate that a subset of genes are regulated by unphosphorylated STAT3, including well - known oncogenes such as MRAS and MET (Yang et al., 2005).

It's well known that one chemical pathway by which muscle cells grow involves growth hormone and one of its subset, IGF - 1.