Sentences with phrase «cell subsets»
"cell subsets" refers to different types or groups of cells that have specific characteristics or functions within a larger group of cells. These subsets can have unique roles and features that contribute to the overall functioning of the group they belong to. Full definition
The adenosine A2A receptor is the main adenosine receptor expressed on immune cell subsets including T - cells, NK cells and dendritic cells.
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We recently reported that CD8 (+) T cells responding to innate - like IL - 12 + IL - 18 stimulation and co-expressing the transcription factor Eomesodermin (Eomes) and KIR / NKG2A membrane receptors with a memory / EMRA phenotype may represent a new, functionally distinct innate T cell subset in humans.
Another unconventional T cell subset with some features of innate immune cells is the intestinal intraepithelial lymphocytes (IEL) that express CD8αα homodimers, but neither CD4 nor CD8αβ.
Calabro et al.: Differential Intrasplenic Migration of Dendritic Cell Subsets Tailors Adaptive Immunity.
B cell subsets contribute to renal injury and renal protection after ischemia / reperfusion.
The adenosine A ₂ ₐ receptor is the main adenosine receptor expressed on immune cell subsets including T - cells, NK cells and dendritic cells and binding of adenosine to the A ₂ ₐ receptor on immune cells blocks the activation and effector functions of anti-tumor immune cells and promotes a regulatory, immune - suppressive phenotype.
Next, we discuss IL - 4 and IL - 15 involvement in the generation of innate CD8 (+) T cells and particularly its possible dependency on the promyelocytic leukemia zinc - finger factor expressing iNKT cells, an innate T cell subset well documented for its susceptibility to tumor immune subversion.
T - cell subsets as well as the inflammatory markers IL - 6, IL - 10, C - reactive protein, transthyretin and albumin were evaluated.
A new Tel Aviv University study published in Nature Nanotechnology proposes a novel approach to manipulate genes using a self - assembling platform that delivers nucleic acids, such as small interfering RNAs (siRNAs), to distinct cell subsets.
«Our data suggests that targeting specific immune cell subsets at defined stages of disease may represent a better approach to therapeutic immunomodulation to improve heart failure.»
He thinks a number of cancer cell subsets are never really affected by most targeted anticancer drugs currently used.
In humans, MAIT cells represent the most abundant T cell subset reacting against bacteria.
Thus, in humans, MAIT cells are the most abundant T cell subset able to detect and kill bacteria infected cells.
The generation of these T cell subsets depends on the action of cytokines such as IL - 6, IL - 12 and IL - 23, produced mostly by cells of the innate immune system.
Effects of Toll - like receptor 4 on β2 - glycoprotein I - induced splenic T cell subsets differentiation
They further suggest that the size of the Ly49 + CD8 + T cell subset marks a history of CD8 + T cell activation that might preferentially result from endogenous inducers of inflammation rather than from microbial infections.
Allergy seasonality: In a large effort supported by a consortium grant from NIAID, the Sette group is collaborating with the Peters and Vijayanand labs to test the hypothesis that different stages (in - season versus out - of - season), types (rhinitis versus asthma), and severities of allergic disease are associated with not only differential magnitude of T cell responses, but also distinctive patterns in terms of the T cell subsets involved and their interactions.
Innate - like functions of natural killer T cell subsets result from highly divergent gene programs.
Identification of myeloid cell subsets in murine lungs using flow cytometry.
Having been excited by the potential of retroviral gene transfer as a therapeutic, it has been a fascinating opportunity to get to grips with the various processes in the lab; particularly more recently when I have spent time working independently to optimise the process in various cell subsets.
Flow cytometry allows researchers to quantify and isolate rare viable cell subsets from heterogenous populations in single - cell suspensions based on differential expression of surface antigens.
Another potential mechanism through which iodine exacerbates or induces Hashimoto's is by up - regulating Th17 cells, the immune cell subset responsible for tissue destruction in autoimmune disease, and by suppressing development of regulatory T cells, the population that invokes oral tolerance to arrest autoimmune responses (31).
Effects of the Novel Anti-Asthenic Drug Ladasten on Behavior and T - Cell Subsets Alterations in a Social Defeat Animal Model of Depression
Shultz LD, Saito Y, Najima Y, Tanaka S, Ochi T, Tomizawa M, Doi T, Sone A, Suzuki N, Fujiwara H, Yasukawa M, Ishikawa F. Generation of functional human T - cell subsets with HLA - restricted immune responses in HLA class I expressing NOD / SCID / IL2r ɣnull humanized mice.
The roles of Toll - like receptor 9, MyD88, and DNA - dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets.
Early Rise of Blood T Follicular Helper Cell Subsets and Baseline Immunity as Predictors of Persisting Late Functional Antibody Responses to Vaccination in Humans Spensieri F., Siena E., Borgogni E., Zedda L., Cantisani R., Chiappini N., Schiavetti F., Rosa D., Castellino F., Montomoli E., Bodinham C.L., Lewis D.J., Medini D., Bertholet S., Del Giudice G. Plos ONE, 2016 11 (6): e0157066.
«Over the past ten years, several research groups, including our own, have shown the importance of certain immune cell subsets in preventing or exacerbating heart disease in mice, but we are just beginning to understand how the metabolism and function of these immune cells change during cardiovascular disease progression in humans,» says Hedrick.
However, little is known in humans about the biology of CD4 - CTL generation, their functional properties, and heterogeneity, especially in relation to other well - described CD4 + memory T cell subsets.
«It's flexible enough to be easily customized to target any cell subset and to knock down any gene of choice.
Among the sleeping group, all measured T cell subsets were reduced within three hours of falling asleep.
Monitoring immune cell activity — including phenotyping immune cell subsets, tracking cell proliferation, and measuring cytokine production — can provide insights into the overall status of immune function in patients, particularly those undergoing immunosuppression after transplants, enduring cancer treatment, or suffering from autoimmune disease or other pathologies that affect the immune system.
«The fact that the field has successfully bioengineered antibodies to oversee the removal of TNF - a suggests that we can design other antibodies to remove spleen - derived immune cell subsets, or the proteins issuing from failing hearts that turn them on,» Prabhu added.
One of these T cell subsets is comprised of the CD1d - reactive invariant natural killer T cells, and over the years we have studied the development, homeostasis, activation and regulation of function of these cells, as well as their specificity and the pathways leading to the processing and presentation of antigens by CD1d.
In this review, after a summary on the known innate CD8 (+) T - cell features in the mouse, we propose Eomes together with KIR / NKG2A and CD49d as a signature to standardize the identification of this innate CD8 (+) T - cell subset in humans.
Coleen McNamara, MD, a Professor of Internal Medicine at the University of Virginia, recently discovered a B cell subset that produces natural antibodies to protect from diet - induced atherosclerosis in mice, and she hopes to gain insights into the equivalent mechanisms in humans.
Alterations in peripheral blood B cell subsets and dynamics of B cell responses during human schistosomiasis.
Her current research interests are studying natural killer cells in tumor micro-environment and studying sex - based differences in immune cell subsets.