Sentences with phrase «cell subsets as»

T - cell subsets as well as the inflammatory markers IL - 6, IL - 10, C - reactive protein, transthyretin and albumin were evaluated.

Not exact matches

A subset of immune cells that manage immune system suppression, known as regulatory T cells, begins learning to tolerate the fetal cells as non-foreign.

Previous approaches were only marginally effective as they reached one set of hair cells in the inner ear, but another subset — equally critical for hearing — remained largely impenetrable.

«Starting with our cell model that mimics human pancreatic cancer progression, we identified released proteins, then tested and validated a subset of these proteins as potential plasma biomarkers of this cancer,» Zaret said.

This analysis suggests that a rare subset of tumor cells harbor different genetic alterations and that those cells serve as the seeds for the recurrence of rhabdomyosarcoma.»

In particular, they found significant expansion of CD3 + CD8 + cytotoxic T - cells and CD3 + CD4 + helper T - cells in circulating blood, as well as increased CD4 + subsets of Th1, Th2, Th17 and Treg cells, indicating a pro-inflammatory response.

Treating the mice with antibodies against CD4 + T - cells four weeks after experimental heart attacks — to deplete that subset of T - cells — prevented the progressive abnormal enlargement of the left ventricle that leads to heart failure, as compared with untreated mice.

The treatment with the engineered immune cells, called CAR - T cell therapy, may work even better if doctors transplant a subset of immune cells known as memory T cells, researchers reported February 14...

The team discovered that a certain subset of cartilage - making cells, known as chondrocytes, replicate themselves, make other bone cells and drive bone growth — findings that could lead to new treatments for children with facial deformities who normally have to wait until adulthood for corrective surgery.

Lee and Cate's research hints that this secret lever, which triggers translation of only a special subset of mRNAs — perhaps only 500 out of some 10,000 mRNAs produced by a cell — will be found to play a critical role in other diseases besides cancer, as well as in plants and animals.

Overall, including all genomic variations present in most if not all tumor cells (clonal) as well as those present only in subsets of the cancer cells (subclonal) from tumor tissue, the researchers detected a total of 864 genetic changes in tissue samples across the three tumor types, and 627 (73 %) of those were also found in the blood.

Lin and Artandi wondered whether they could use telomerase expression as a marker to identify the subset of cells responsible for regenerating the liver during normal turnover.

«We already know white blood cells — or specifically, a subset known as T lymphocytes — provide us with a natural defence against viruses,» said Dr Ann Ager, who led the research.

One of these T cell subsets is comprised of the CD1d - reactive invariant natural killer T cells, and over the years we have studied the development, homeostasis, activation and regulation of function of these cells, as well as their specificity and the pathways leading to the processing and presentation of antigens by CD1d.

Systemic vs. mucosal immunisation regimens will be compared for optimal induction of innate and adaptive immune cell subsets, including Th1, Th2, Th17, Th22 and regulatory T cells, as well as inflammation genes.

The generation of these T cell subsets depends on the action of cytokines such as IL - 6, IL - 12 and IL - 23, produced mostly by cells of the innate immune system.

In this review, after a summary on the known innate CD8 (+) T - cell features in the mouse, we propose Eomes together with KIR / NKG2A and CD49d as a signature to standardize the identification of this innate CD8 (+) T - cell subset in humans.

New research from La Jolla Institute for Allergy and Immunology lays the groundwork to parse how the virus interacts with its host and causes disease by pinpointing CD8 + T cells, a subset of T cells more commonly known as cytotoxic or killer T cells, as important gatekeepers that control Zika infection or limit the severity of disease.

Scientists from the Sundrud lab have identified a normally small subset of immune cells that may play a major role in the development of Crohn's disease as well as steroid resistance associated with the disease.

A human peripheral blood monocyte - derived subset acts as pluripotent stem cells.

Hedrick, whose laboratory will focus on the role of cholesterol and LDL in reprogramming specific subsets of immune cells as part of the Program Project Research grant, has assembled a high - powered, multi-institutional team, including investigators from UC San Diego and the University of Virginia.

«We noticed that tumors with elevated beta - catenin lacked a subset of dendritic cells known as CD103 +,» said co-author Stefani Spranger, PhD, post-doctoral fellow in the University of Chicago's Department of Pathology.

In addition, the CD8 subset primarily function as cytolytic killers for clearing pathogen - infected cells or for targeting tumors.

Chief among them was the finding that in all placental mammals FOXP3 acts through a snippet of DNA called the CNS1 enhancer to trigger the formation of a cohort of Tregs designated «peripheral» (whereas most Tregs are produced in the thymus gland, which sits between the lungs, a subset of the cells act as sentinels suppressing runaway immune responses in the body's peripheral tissues).

It was heterozygous in most patients, homozygous in a subset as a result of mitotic recombination, and arose in a multipotent progenitor capable of giving rise to erythroid and myeloid cells.

According to Whitehead Institute researchers, a protein known as monocarboxylate transporter 1 (MCT1), which is highly expressed in a subset of metabolically altered cancer cells, is needed for the entry of the investigational cancer drug 3 - bromopyruvate (3 - BrPA) into malignant cells.

Early Rise of Blood T Follicular Helper Cell Subsets and Baseline Immunity as Predictors of Persisting Late Functional Antibody Responses to Vaccination in Humans Spensieri F., Siena E., Borgogni E., Zedda L., Cantisani R., Chiappini N., Schiavetti F., Rosa D., Castellino F., Montomoli E., Bodinham C.L., Lewis D.J., Medini D., Bertholet S., Del Giudice G. Plos ONE, 2016 11 (6): e0157066.

During her doctoral studies, Sasha investigated primary human immunodeficiencies, lymphocyte cell death and metabolic pathways as well as memory T cell subsets in the laboratory of Dr. Andrew Snow.

We investigate which CD4 T cell subsets serve as predominant niches for viral long - term persistence, and aim at identifying specific molecular pathways in these cells that can be targeted to reduce viral persistence.

In their latest study, researchers at La Jolla Institute for Allergy and Immunology (LJI) identified a subset of T cells, whose frequency serves as early childhood immune signature that predicts the risk of developing asthma later on.

In their latest study, published in the Nov. 2, 2015, advance online issue of Nature Immunology, researchers at the La Jolla Institute for Allergy and Immunology report that these disease - causing autoimmune T cells are lured into the nervous system by monocytes and macrophages, a subset of immune cells better known as the immune system's cleanup crew.

Similarly, microarray analyses comparing global gene expression in cells that overexpress wild - type STAT3 or phosphorylation - deficient mutant indicate that a subset of genes are regulated by unphosphorylated STAT3, including well - known oncogenes such as MRAS and MET (Yang et al., 2005).

However, despite numerous papers being published demonstrating bulk memory B cell culture, we could find no literature on optimised conditions for the study of memory B cell subsets, such as IgM ⁺ memory B cells.

Having been excited by the potential of retroviral gene transfer as a therapeutic, it has been a fascinating opportunity to get to grips with the various processes in the lab; particularly more recently when I have spent time working independently to optimise the process in various cell subsets.

Aneuploidies frequently affect only a subset of cells in a sample; this is known as «mosaic» aneuploidy.

In addition, Chk1 inhibition is highly effective as monotherapy in a subset of cancer cell lines (Thompson and Eastman, Brit J Clin Pharm 2013).

Included in the T cells category is a subset of cells known as Th17, which adaptively develop, as needed, to address incoming threats.

These cells, along with dendritic cells, recognize the incoming undigested food particles, toxic agents, and bacterial components as foreign invaders, and present them to cells of the adaptive immune system called T and B lymphocytes, leading to clonal expansion (proliferation or multiplication of specific subsets of T and B cells) and recruitment of more pro-inflammatory immune cells to the gut through a process called leukocyte homing.

A subset of the «Cells,» the «Portrait Cells» present a concentrated portrait of a psychological or emotional state, and usually give prominence to the human head as the seat of identity.