Sentences with phrase «cell subsets at»

«Our data suggests that targeting specific immune cell subsets at defined stages of disease may represent a better approach to therapeutic immunomodulation to improve heart failure.»

Not exact matches

Biophysicists led by Professor Erwin Frey, who holds the Chair of Biological and Statistical Physics at LMU, have now shown theoretically how this can be accomplished even when only a subset of cells actually emits the requisite signals.

Single - cell differential gene expression analysis revealed a spectrum of known transcripts, including several linked to cytotoxic and costimulatory function that are expressed at higher levels in the TEMRA (effector memory T cells expressing CD45RA) subset, which is highly enriched for CD4 - CTLs, compared with CD4 + T cells in the central memory (TCM) and effector memory (TEM) subsets.

The team, which included members of the Health Science Center departments of medicine and biochemistry, investigators from the UT Southwestern Medical Center at Dallas and a group of collaborators from Austria, found that the gene that codes the enzyme D2 - hydroxyglutarate dehydrogenase (D2HGDH) is mutated in a subset of cancers called diffuse large B - cell lymphomas.

It suggests that at the root of any cancer there is a small subset of cancer cells that are solely responsible for driving the growth and evolution of a patient's cancer.

Although it is among the most highly metastatic of all cancers, multiple myeloma is driven to spread by only a subset of the myeloma cells within a patient's body, researchers at Dana - Farber Cancer Institute have found in a study presented at the annual meeting of the American Society of Hematology (ASH).

- In a study with potentially major implications for the future treatment of autoimmunity and related conditions, scientists from the Perelman School of Medicine at the University of Pennsylvania have found a way to remove the subset of antibody - making cells that cause an autoimmune disease, without harming the rest of the immune system.

Their studies revealed that a subset of normal breast precursor cells, called luminal progenitors, have dangerously short telomeres and display a correspondingly high level DNA damage response localized at their chromosome ends.

Dr Peter Rugg - Gunn, group leader in the Babraham Institute's Epigenetics research programme and a senior co-author on the paper, explains: «One of the exciting aspects of this study is that we were able to capture naïve stem cells at a very early stage of their reprogramming — these early cells had switched on a subset of naïve - specific genes, but they had not yet fully matured.

In the cells of humans and other organisms, only a subset of genes are active at any given time, depending largely on the stage of life and the particular duties of the cell.

By looking at the hippocampus in 55 post-mortem brains aged between 19 and 92, Frisén's team found that a subset of neurons in an area of the hippocampus called the dentate gyrus are indeed created throughout adulthood (Cell, doi.org/ms8).

We will develop mathematical models to predict the pathways of differentiation from naive to memory and effector T - cell subsets based on the characterisation of surface marker expression, transcription factors and cytokines production at early and late time points after immunisation.

Most importantly, by looking at a single cell level, researchers were able to correlate the chromosomal make - up of an embryo to a subset of 12 genes that are activated prior to the first cell division.

Enhanced expression of one of these molecules, CD1d, is coupled to selective induction of invariant natural - killer T cells (iNKT), a subset of T lymphocytes that are present at low levels in lymphocyte populations and whose absence enhances autoimmunity in animal models.

Coleen McNamara, MD, a Professor of Internal Medicine at the University of Virginia, recently discovered a B cell subset that produces natural antibodies to protect from diet - induced atherosclerosis in mice, and she hopes to gain insights into the equivalent mechanisms in humans.

In addition, the data showed that the gut's hormone - producing enteroendocrine cells (EECs)-- long divided into subsets based on the idea that each only expressed a single hormone — can actually express multiple hormones at once.

In this effort, Dr. Zuniga made a major «hit» while a postdoctoral fellow at the Scripps Research Institute, when she initiated study into plasmacytoid dendritic cells, a subset of leukocytes that produce large quantities of the antiviral mediators type I interferons, and have significant developmental potential.

Researchers at La Jolla Institute for Allergy and Immunology have identified a subset of T cells, whose...

We investigate which CD4 T cell subsets serve as predominant niches for viral long - term persistence, and aim at identifying specific molecular pathways in these cells that can be targeted to reduce viral persistence.

At T4 the changes were apparent in a number of the T - cell subsets, but particularly in the CD8 + CD28 - and CD57 + subsets.

In their latest study, researchers at La Jolla Institute for Allergy and Immunology (LJI) identified a subset of T cells, whose frequency serves as early childhood immune signature that predicts the risk of developing asthma later on.

In their latest study, published in the Nov. 2, 2015, advance online issue of Nature Immunology, researchers at the La Jolla Institute for Allergy and Immunology report that these disease - causing autoimmune T cells are lured into the nervous system by monocytes and macrophages, a subset of immune cells better known as the immune system's cleanup crew.

Some of the earliest studies of cancer genomes in AML noted that, within a single patient, there were subsets of mutations present at lower allele frequencies, suggesting that they're not present in all cells.

Even cells at the top of the hierarchy generally express only a subset of the stem cell genes studied.