The generation of these T
cell subsets depends on the action of cytokines such as IL - 6, IL - 12 and IL - 23, produced mostly by cells of the innate immune system.
Not exact matches
In the
cells of humans and other organisms, only a
subset of genes are active at any given time,
depending largely on the stage of life and the particular duties of the
cell.
Because our current understanding suggests these molecules control many functional activities of T
cells, and the effects might vary
depending on the
subset of T
cell, they are therefore potential targets for either suppressing an immune response, or for promoting an immune response.
With their deep expertise in the biology of senescent
cells, the Campisi lab will be focused on fundamental research into questions like how senescent
cells vary in their susceptibility and resistance to immune clearance (
depending on factors like their tissues of residence or the pathway that led them into senescence); the targets and mechanisms used by NK
cells to clear senescent
cells; and why
subsets of senescent
cells might persist when their similarly - situated neighbors are cleared out (and what might allow us to overcome that resistance).
Kronenwett et al. «Oligodeoxyribonucleotide Uptake in Primary Human Hematopoietic
Cells Is Enhanced by Cationic Lipids and
Depends on the Hematopoietic
Cell Subset», Blood, 91 (3): 852 - 862, 1998.