Sentences with phrase «cell subsets with»

Shultz LD, Saito Y, Najima Y, Tanaka S, Ochi T, Tomizawa M, Doi T, Sone A, Suzuki N, Fujiwara H, Yasukawa M, Ishikawa F. Generation of functional human T - cell subsets with HLA - restricted immune responses in HLA class I expressing NOD / SCID / IL2r ɣnull humanized mice.

Another unconventional T cell subset with some features of innate immune cells is the intestinal intraepithelial lymphocytes (IEL) that express CD8αα homodimers, but neither CD4 nor CD8αβ.

Not exact matches

The new findings build on prior research from the Dhodapkar lab demonstrating that patients with Gaucher disease, an inherited lipid storage disorder, have a significant increased risk for developing myeloma; and the discovery of a subset of lipid - reactive immune cells, called type II NKT - TFH, that promote the development of plasma cells.

«Starting with our cell model that mimics human pancreatic cancer progression, we identified released proteins, then tested and validated a subset of these proteins as potential plasma biomarkers of this cancer,» Zaret said.

It indicates that the interaction with mitochondria is driven by Toxoplasma, rather than the host cell, and it is likely something the parasite does «to enable survival in some particular subset of hosts,» he says.

Treating the mice with antibodies against CD4 + T - cells four weeks after experimental heart attacks — to deplete that subset of T - cells — prevented the progressive abnormal enlargement of the left ventricle that leads to heart failure, as compared with untreated mice.

Indeed, when Blanpain and his colleagues examined mice with squamous cell carcinoma, a malignant outgrowth of the papilloma, they found that most of the cells were actively dividing, not just a small subset of stem - cell - like cells.

We identified distinct clusters of CD4 - CTL effector and precursor cells in the TEMRA subset; the precursor cells shared TCR clonotypes with CD4 - CTL effectors and were distinguished by high expression of the interleukin - 7 receptor.

Single - cell differential gene expression analysis revealed a spectrum of known transcripts, including several linked to cytotoxic and costimulatory function that are expressed at higher levels in the TEMRA (effector memory T cells expressing CD45RA) subset, which is highly enriched for CD4 - CTLs, compared with CD4 + T cells in the central memory (TCM) and effector memory (TEM) subsets.

Simultaneous T cell antigen receptor (TCR) analysis in single cells and bulk subsets revealed that CD4 - TEMRA cells show marked clonal expansion compared with TCM and TEM cells and that most of CD4 - TEMRA were dengue virus (DENV)-- specific in donors with previous DENV infection.

The treatment with the engineered immune cells, called CAR - T cell therapy, may work even better if doctors transplant a subset of immune cells known as memory T cells, researchers reported February 14...

To confirm that the missing mutations were important for generating an immune response, the researchers cultured a subset of the neoantigen protein fragments containing the tumor mutations with immune cells taken from three patients» blood samples.

- In a study with potentially major implications for the future treatment of autoimmunity and related conditions, scientists from the Perelman School of Medicine at the University of Pennsylvania have found a way to remove the subset of antibody - making cells that cause an autoimmune disease, without harming the rest of the immune system.

Now, researchers have found that a very small subset of anti-viral immune cells, transplanted along with a donor's blood stem cells, could be enough to fight and even prevent the disease caused by CMV, in research conducted in mice and published Jan 16th in the Journal of Immunology.

The team discovered that a certain subset of cartilage - making cells, known as chondrocytes, replicate themselves, make other bone cells and drive bone growth — findings that could lead to new treatments for children with facial deformities who normally have to wait until adulthood for corrective surgery.

Additional experiments with transgenic mice indicated that L1 had hopscotched in a subset of brain cells, but not in the cells of most other tissues.

«We already know white blood cells — or specifically, a subset known as T lymphocytes — provide us with a natural defence against viruses,» said Dr Ann Ager, who led the research.

Ralph Steinman and Nina Bhardwaj, independently with other laboratories, discover the plasmacytoid dendritic cell (pDC) subset in circulating blood.

Regulatory T cells (Tregs) are a unique subset of CD4 + T cells with immunosuppressive properties.

These studies have given us a better understanding of the genes that influence the development of these cells, and in particular, to characterize the differences between subsets of Vα14i NKT cells with distinct functional properties.

However, it is also possible to induce such responses using protein antigens, if there is a signal that promotes cross-presentation and targeting to specific dendritic cell (DC) subsets with the capacity to cross-present antigens.

Smaller subsets of T cells are reactive toward various nonpeptidic ligands associated with nonpolymorphic MHC class - Ib (MHC - Ib) molecules.

We recently reported that CD8 (+) T cells responding to innate - like IL - 12 + IL - 18 stimulation and co-expressing the transcription factor Eomesodermin (Eomes) and KIR / NKG2A membrane receptors with a memory / EMRA phenotype may represent a new, functionally distinct innate T cell subset in humans.

Together with the more studied regulatory T cells (Tr1 and CD25 + FOXP3 + Treg), growing evidence indicates that different subsets of dendritic cells (DC), play a critical role in promoting immune tolerance.

Our laboratory has assembled a comprehensive set of tools for doing this, including mice with conditional ablation of the Btla gene in different subsets of immune cells.

In this review, after a summary on the known innate CD8 (+) T - cell features in the mouse, we propose Eomes together with KIR / NKG2A and CD49d as a signature to standardize the identification of this innate CD8 (+) T - cell subset in humans.

New research from La Jolla Institute for Allergy and Immunology lays the groundwork to parse how the virus interacts with its host and causes disease by pinpointing CD8 + T cells, a subset of T cells more commonly known as cytotoxic or killer T cells, as important gatekeepers that control Zika infection or limit the severity of disease.

Scientists from the Sundrud lab have identified a normally small subset of immune cells that may play a major role in the development of Crohn's disease as well as steroid resistance associated with the disease.

Although similar numbers of total splenic gp33 - LCMV — specific T cells were observed between genotypes (Fig. 5B), the distribution of gp33 - LCMV — specific CD8 + T cell effector and memory subsets were altered, such that there was a significantly lower percentage of short - term effector T cells and reciprocal changes in memory precursor cells among gp33 - specifc CD8 + T cells in WT relative to DKO mice (Fig. 5C), with a trend in changes in absolute cell numbers, consistent with temporal data from peripheral blood (Fig. 5A).

Notably, both in hphep cells and enhanced hiPS - HEP cultures, only a subset of hepatocytes is strongly stained for glycogen storage — again in agreement with the metabolic zonation observed in the liver lobe (Figure 3, Panel A).

Notably, both in hphep cells and the enhanced hiPS - HEP cultures, only a subset of hepatocytes is strongly stained for glycogen storage (shown by Periodic acid - Schiff staining, below)-- again in agreement with the metabolic zonation observed in the liver lobe.

The team has therefore proposed a new taxonomy for EECs based on their expression profile data, with many new subsets of hormone - producing cells.

Rather, each tumor contains a small subset of cells with stem cell - like capacities that are responsible for initiating and sustaining tumor growth, while the bulk of the tumor cells lacks this ability.

Interaction of human mesenchymal stem cells with cells involved in alloantigen - specific immune response favors the differentiation of CD4 + T - cell subsets expressing a regulatory / suppressive phenotype.

With their deep expertise in the biology of senescent cells, the Campisi lab will be focused on fundamental research into questions like how senescent cells vary in their susceptibility and resistance to immune clearance (depending on factors like their tissues of residence or the pathway that led them into senescence); the targets and mechanisms used by NK cells to clear senescent cells; and why subsets of senescent cells might persist when their similarly - situated neighbors are cleared out (and what might allow us to overcome that resistance).

«We noticed that tumors with elevated beta - catenin lacked a subset of dendritic cells known as CD103 +,» said co-author Stefani Spranger, PhD, post-doctoral fellow in the University of Chicago's Department of Pathology.

(14,15)-RRB- have found age - related satellite cell attrition consistent with the senescence of a subset thereof; moreover, one such study (15) reported that decreases in the number and quality of satellite cells with aging are reliably associated with elevated expression of p16Ink4a (contrary to (14)-RRB-, and with secretory and proteomic abnormalities consistent with a rising burden of senescent cells.

iTeos focuses upon selected key suppressive mechanisms of immunity in cancer based on gene expression, association with immune cell subsets, protein expression in human tumors and biological validation.

The fundamental impact of this research will be greater insight into whether infection and vaccination lead to expansion or contraction of subsets already present within the individual's T cell pool that maintain their phenotype, and / or lead to differentiation or activation of T cells into states uniquely associated with those conditions.

A Small Case Series of Intravascular Large B - Cell Lymphoma with Unexpected Findings: Subset of Cases with Concomitant Extravascular Central Nervous System (CNS) Involvement Mimicking Primary...

In most cases, there was no evidence of dopaminergic cell death in the substantia nigra, with the exception of one of the more recent studies that observed it in a subset of DJ - 1 − / − mice (Rousseaux et al., 2012).

High - resolution maps of enhancer - promoter interactions in rare primary human T cell subsets and coronary artery smooth muscle cells link variants associated with autoimmune and cardiovascular diseases to target genes.

These include: a) Global Clusters that consist of a small, tight subset of genes that are co-expressed under the entire spectrum of experimental conditions; b) Time Series of gene expression profiles during successive days of standard ES cell differentiation; c) Specific Gene Classes based on hierarchical clustering of transcriptional factors and ESTs; d) Expression Waves of genes with characteristic expression profiles during ES cell differentiation, juxtaposed to waves of genes that behave in the exact opposite way; e) Pathway Animations that illustrate dynamic changes in the components of individual KEGG signaling and metabolic pathways viewed in time - related manner; and, f) Search Engines to display the expression pattern of any transcript, or groups of transcripts, during the course of ES cell differentiation, or to query the association of candidate genes with various FunGenES database clusters.

Having been excited by the potential of retroviral gene transfer as a therapeutic, it has been a fascinating opportunity to get to grips with the various processes in the lab; particularly more recently when I have spent time working independently to optimise the process in various cell subsets.

Under the guidance of a world - renowned cancer biologist, Robert Weinberg, Ph.D., Lu is focusing on how metastatic breast cancer cells interact with a subset of immune cells called macrophages, which normally are capable of engulfing — literally eating — infected, damaged, or cancerous cells.

After 4 weeks of differentiation, the majority of the cells (> 60 %) expressed the postmitotic neuronal marker β - III tubulin with a subset (about 50 % of total neurons) additionally expressing TH, a marker for midbrain dopaminergic neurons (Fig. 3A — D).

There it correlates with gene repression, but likely only in distinct subsets of cells within each organ, (see Schultz et al., 2015).

These cells, along with dendritic cells, recognize the incoming undigested food particles, toxic agents, and bacterial components as foreign invaders, and present them to cells of the adaptive immune system called T and B lymphocytes, leading to clonal expansion (proliferation or multiplication of specific subsets of T and B cells) and recruitment of more pro-inflammatory immune cells to the gut through a process called leukocyte homing.

This subset of scales from the FES and their composite score has been used with families of children with asthma, diabetes, juvenile rheumatoid arthritis, recurrent abdominal pain, sickle cell disease, and those undergoing bone marrow transplant (BMT).