Bcl - 2 proteins play a key role in cell survival by protecting against a form of
cell suicide known as apoptosis.
MAPK regulates cell functions, including proliferation, gene expression, differentiation, cell division and a form of
cell suicide known as apoptosis.
The scientists discovered that dinaciclib, by interfering with UPR activation, caused multiple myeloma and myeloid leukemia cells to initiate a form of
cell suicide known as apoptosis when exposed to agents that induced ER stress.
Not exact matches
Myc
no longer was able to drive tumor growth, cancer
cells committed
suicide, and the treated mice survived longer.
They also tested other chemicals
known to prevent the other two forms of cellular
suicide, but only CGP3466B protected mouse nerve
cells in the brain from death by cocaine.
ABT - 737 targets proteins
known as B -
cell lymphoma 2 (Bcl - 2) and Bcl - xL, which prevent apoptosis, a form of
cell suicide, in cancer
cells.
However, in developing brain
cells, the researchers found TLR3 activation also influences 41 genes that add up to a double whammy in this model — diminished stem
cell differentiation into brain
cells and increased
cell suicide, a carefully controlled process
known as apoptosis.
Knowing the structure of survivin «doesn't clear up the controversy» about how it prevents
cell suicide, says biochemist Guy Salvesen of the Burnham Institute in La Jolla.
Earlier research had shown that
cells surrounding an HIV - infected
cell die as a result of apoptosis, or programmed
cell suicide, and scientists
knew that Nef had a hand in starting that process.