Sentences with phrase «cell surface markers for»

«We've not had cell surface markers for the different stem cell states before, which has made it hard to study them,» says Fredrik Lanner, assistant professor at Karolinska Institutet's Department of Clinical Science, Intervention and Technology.

However, SSEA1 can be a useful cell surface marker for the detection and enrichment of putative germ cells derived from ES cells as reported previously [56].

Not exact matches

His work indicates that this cell surface marker could serve as a target for a novel brain cancer vaccine or T - cell therapies engineered to recognize and kill tumors carrying that neoantigen.

For instance, LKB1 also helped to repress cell surface markers on immune cells called dendritic cells that fueled the allergic reaction.

The use of cell surface markers to isolate specific cell populations is one common method for separating cells; however, isolating live cells based on their RNA expression is a powerful new way enabling the study of small cell niches in nongenetically modified animal models and human tissue.

Researchers at Karolinska Institutet have identified cell surface markers specific for the very earliest stem cells in the human embryo.

The group was then able to sort the cells using markers expressed on the cell surface, to help pull out successfully edited cells for research, and eventually for therapeutic use.

«But the desired cells often lack a readily accessible surface marker, or that marker is not specific enough, as is the case for cardiac muscle cells.

The scientists also found that a protein known as CD29 acts as a cell - surface marker for precursor fat cells that can generate mature cells with high energy potential, as shown by their UCP1 expression.

But the new data reveals that oRGs bring a support group with them: The cells express genes for surface markers and molecular signals that enhance their own ability to proliferate, the researchers found.

There are no specific markers to identify them; however, they are negative for hematopoietic cell markers like CD34 / 45 / HLA - DR and express CD90 / 73/105 on their surface 2, 3, 4.

Asialoglycoprotein receptor 1 is a specific cell - surface marker for isolating hepatocytes derived from human pluripotent stem cells.

The authors used the cell surface marker podoplanin as a handle for isolating the progenitor cells from bone marrow.

Purified cells were surface stained for a variety of leukocyte markers and analyzed using flow cytometry.

Cells were stained with antibodies specific for human cell surface markers: CD326 / ESA - FITC, CD24 - PE, and CD44 - PE - Cy7 (BD Pharmingen, San Jose, CA, USA).

The B cell depleted fraction was then surface stained for lineage markers (CD3, CD19, CD14), CD127 and cells were sorted (Lin - CD127 +).

Cells were washed with 1 % BSA and stained with surface markers for ILC3.

(A) Flow cytometry of two independent HV clones (HV 5.1 and HV 16.1) cultured either under self - renewing conditions or in the absence of LIF show the presence of a subpopulation of cells positive for Venus and / or the ES cell surface marker SSEA - 1.

People who had a better antibody response to the vaccine after 28 days had higher levels of HLA - DR (a cell surface protein which is a marker for immune stimulation) on a specialised type of dendritic cell.

The success of marker - based approaches for dissecting haematopoiesis in mouse and human is reliant on the presence of well - defined cell surface markers specific for diverse progenitor populations.

Single cell Q - RTPCR for the genes indicated was carried out on cells separated by flow cytometry on the basis of cell surface marker expression.

Oct - 4 is most consistently expressed of the pluripotency genes that we have studied, and it is switched off only in populations that have lost other measurable features of pluripotency, such as stem cell surface marker expression and the capacity for self - renewal.

Haihui Lu, Ph.D., a CRI fellow at the Whitehead Institute for Biomedical Research, has identified a surface marker that distinguishes a population of breast cancer cells that are more prone to metastasis and demonstrate higher levels of «stemness,» the ability to seed other tumors.