Sentences with phrase «cell surface receptors»

This communication involves the release of chemicals from neurons that stimulate cell surface receptors on other neurons.

Another lab ran into a similar problem when it tried to replicate work by Stanford stem cell biologist Irving Weissman and his colleagues, who reported in 2012 in the Proceedings of the National Academy of Sciences that an antibody to a tumor cell surface receptor called CD47 can slow tumor growth in mice.

Not only did the cells churn out CRH, they also harbored cell surface receptors for the hormone.

In addition, exhausted CD8 T cells start to express inhibitory cell surface receptors that receive and feed inhibitory signals into the cell establishing a negative feedback loop.

To improve the safety of CAR - T treatment, researchers are now engineering «suicide switches» into the cells, genetically encoded cell surface receptors that trigger the cell to die when a small molecule drug binds them.

Through binding cell surface receptors [IFN receptor (IFNR)-RSB-, IFNα activates classic JAK - STAT pathway, which in turn leads to the formation of ISGF3 complex.

A given rise of [Ca2 +] i elicited by the chemotactic peptide formylmethionylleucylphenylalanine (FMLP) was associated with a much greater degree of superoxide generation and myeloperoxidase secretion than was the same or larger [Ca2 +] i produced by a specific calcium ionophore, ionomycin, which bypasses cell surface receptors.

The paper, by V. Hegenauer at University of Tübingen in Tübingen, Germany, and colleagues was titled, «Detection of the plant parasite Cuscuta reflexa by a tomato cell surface receptor.»

In the findings, published in the Journal of Clinical Investigation on December 11, researchers reveal that co-expression of cell surface receptor integrin αvβ3 and transcription factor Slug — a master regulator of a cell's ability to self - renew and differentiate — identifies rare stem - like cells in patient - derived tumor samples that are associated with metastasis.

Microbes that cause diseases like HIV, malaria, and hepatitis C exploit and often activate the same checkpoint pathways — cell surface receptors such as CTLA4 and PD - 1 — to slow immune cells and prevent their elimination by the host.

Current treatments focus on modulating cell surface receptor response, especially dopamine receptors.

Many of the lysosomal proteases are active at neutral pH and this would mean that they could potentially cleave cell surface receptors and cell adhesion molecules.

The Baird / Holowka laboratory employs a broad range of biochemical, biophysical, and imaging methods to investigate the structure and molecular mechanisms of cell surface receptors in the immune response.

Current studies focus mainly on two receptor systems - the mast cell surface receptor, FcεRI, and the receptor for epidermal growth factor that operate in immunological and cell proliferation responses.

Encapsulated with the PLGA are molecules of a 25 - amino acid peptide that acts to resolve inflammation through binding to important cell surface receptors.

Endocytosis has traditionally been viewed as a mechanism for achieving signal attenuation: activated cell surface receptors are internalised and trafficked through endocytic vesicles to lysosomes, where they are degraded.

At the heart of the pathway lies the daf - 2 gene, which encodes a member of the insulin family of cell surface receptors.

This affords safe passage to a theoretically unlimited selection of carriers targeting distinct cell surface receptors.»

«Cell surface receptors for signal transduction and ligand transport - a design principles study.»

In 1997, Ruvkun and his associates isolated and sequenced the daf - 2 gene from C. elegans and showed that it resembles human genes that encode cell surface receptors that bind insulin and insulin - like growth factor - 1.

Moreover, the intact mAb 5.91 was able to bind the free IgE to prevent it from binding cell surface receptors.

In my cell biology course, we investigate the biology and chemistry of a cell surface receptor that helps induce good feelings in us when it binds to a chemical compound found in incense; this may help explain why so many different cultures and religions have independently evolved the use of incense in their ceremonies and rituals.

A cell surface receptor called a Vasopressin Receptor [1] and its length seems to be solely responsible for whether or not men are naturally prone to monogamy or not.

Investigators linked the ability of regulatory T cells to dampen the Th2 response in part to the ability of LKB1 to restrain expression of the cell surface receptor PD - 1 and possibly other receptors.

These are proteins whose amino acid sequences show the structural hallmarks of cell surface receptors but whose triggering molecules are as yet undiscovered.

«Beta blockers may lead to new novel triple negative breast cancer treatments: New research suggests that adrenaline can act on tumor cells via a cell surface receptor called the beta2 - adrenoceptor and that changes in signaling within the cell make it highly invasive.»

In this study, we examined the effectiveness of a vaccination targeting tumors that produced IL - 15 and its cell surface receptor called IL - 15R - alpha -LRB--RRB- and examined their ability to up - regulate (or increase) immune responses to tumor antigens,» Morris says.

This in vivo reconstitution system provides a new approach for examining ligand binding and G protein coupling to cell surface receptors.

The experimental drug cediranib blocks the cell surface receptor VEGF, which stimulates the growth of new blood vessels to feed the growth of tumours,» explains study researcher Dr Paul Symonds, of the Department Cancer Studies & Molecular Medicine at the University of Leicester, UK.

The researchers have found that axons receive the message to die as a chemical signal via a cell surface receptor known as «death receptor 6.»

The mutation in ACVR1 (mACVR1) causes the ACVR1 protein, a cell surface receptor, to be mildly overactive, thereby stimulating the BMP pathway continuously, like a faucet that drips water when it should be turned off.

In man, the neurotransmitter NPY communicates with four well - known «cell surface receptors» in the brain (Y1, Y2, Y4 and Y5), which in turn trigger the system's effects.

A novel monkey study shows promise with a gene therapy that produces a protein fusing bits of antibodies and cell surface receptors

News of the patent on CCR5, a cell surface receptor that HIV uses to gain entry to a cell, gave HGS a big boost: Its stock, after declining a week before, skyrocketed on 16 February to a new high, $ 188 per share, gaining more than 21 % in a day.

If interactions between IL - 15 and IL - 15Rα were to occur strictly as a secreted cytokine binding to a cell surface receptor, then similar exercise and muscle phenotypes would have been observed in both IL - 15Rα — KO mice and IL - 15 — KO mice, since ligand - receptor binding would have been interrupted in both of these mouse strains.

The cell surface receptor HAESA (blue) is bound to the hormone IDA (magenta) and the helper protein SERK1 (orange).

We have compiled a large panel of proteins representing the cell surface receptor repertoire and secreted proteins from the blood stage of the malaria parasite.

Even before the lentiviral envelope protein attaches to cell surface receptors, other important binding events take place during the course of infection.

P2 receptors are a family of cell surface receptors that mediate a wide variety of physiologic effects in response to extracellular nucleotides.

Recognition of IL - 23 by its cell surface receptor on cells primarily activates JAK2 and the downstream transcription factor STAT3 [44].

One known function of AvrPtoB is to block the actions of the cell surface receptors that trigger PTI.

Microbial nucleic acids are generally not directly accessible to cell surface receptors.