Sentences with phrase «cell surface receptors for»

«Cell surface receptors for signal transduction and ligand transport - a design principles study.»

Not only did the cells churn out CRH, they also harbored cell surface receptors for the hormone.

Not exact matches

At the end of September, the European Commission approved a marketing application for Lutathera, a radioactive molecule that targets specific receptors found on the surface of neuroendocrine tumor cells.

When similar analysis was performed on the db mice, it was found that the disrupted db gene was responsible for encoding a protein that functions as a leptin receptor: When it binds circulating leptin at the cell surface, it sets in motion a biochemical cascade inside the cell.

Called TSH for short, this hormone attaches to a receptor on the thyroid cell surface, triggering a series of signals that provoke the gland to pump out thyroid hormones.

One key gene encodes the making of a receptor called TREM2, a docking site for molecules on the surface of microglia and other innate immune cells.

He determined that epithelial cells lining the brain's blood vessel walls contain a surface protein, or receptor, that can snag insulin, the hormone essential for metabolizing carbohydrates and fats.

Work is now continuing to study what transmitter substance and what receptor on the surface of the cell are responsible for the newly discovered timing mechanism.

A critical discovery in this research was finding that the novel progenitor has a receptor protein on its cell surface called KDR, or vascular endothelial growth factor receptor 2, which until now, was thought to be restricted to endothelial cells that form vessels, the progenitors for endothelial cells and the progenitors blood cells.

«Cell - surface receptor offers promising breakthrough for pancreatic cancer patients.»

They injected a mutant gene for a cell - surface receptor for bmp into the right legs of two - day - old chicken embryos.

«The NILR1 is the genetic code for a receptor protein that is localized to the surface of plant cells and is able to bind and recognize other molecules,» says Prof. Florian Grundler, chair at the Department of Molecular Phytomedicine at the University of Bonn.

Normally, antibodies that react to surface receptors unique to the desired cell are used for this purpose.

MERS CoV (CoV stands for coronavirus) has on its surface an array of spike - shaped proteins that bind to host cells — specifically to receptor proteins called DPP4 on the surface of cells that line human airways.

Most resistance genes, in wheat and other plants, code for protein receptors located inside cells; the Stb6 gene codes for a receptor protein on the cell's surface.

The networks provide structural integrity to tissues and serve as ligands for integrin cell - surface receptors.

This in vivo reconstitution system provides a new approach for examining ligand binding and G protein coupling to cell surface receptors.

Once they found the match, the researchers had the D - peptides synthesized and tested for their ability to activate their receptors on the cell's surface.

Over the past 30 years, scientists have found that strong input to a postsynaptic cell causes it to traffic more receptors for neurotransmitters to its surface, amplifying the signal it receives from the presynaptic cell.

Now a team of researchers led by Philip Kim, a professor of computer science and molecular genetics in the University of Toronto's Donnelly Centre for Cellular and Biomolecular Research, has developed a new technology for making mirror - image peptides, which bind and activate receptors on the surface of cells.

The scientists also found that endothelial cells themselves give the signal for their own death: To do this, the vascular wall cells have a receptor molecule called Death Receptor 6 (DR6) on their receptor molecule called Death Receptor 6 (DR6) on their Receptor 6 (DR6) on their surface.

Based on meta - analysis of over 100 studies of transmembrane cell - surface receptors, as well as his own research, Prof. Maruyama proposed a new model for receptor activation — the «rotation model.»

Dr. Shiloh and his team currently are working to discover the human cell - surface receptors for Mtb that are involved in the bacteria's M - cell translocation, as well as to determine the exact machinery used by the cell to move the bacteria from the surface to the bottom of the cell.

For example, Dr. Shiloh said, preventing Mtb from attaching to receptors on the M - cell surface — such as by vaccinating against a bacterial protein — could block the bacteria's entry, infection, and spread to other organs.

Both genes code for proteins that function as growth factor receptors, meaning they sit on the surface of cells and, when activated, can spur the rapid cell growth that is a hallmark of cancer.

For HIV to enter T cells, the virus first binds to a primary surface receptor CD4 and then to a coreceptor, either CCR5 or CXCR4.

The authors catalogued several co-stimulatory molecules and receptors present on the surfaces of the PD -1-responsive T cells, which possibly could be targets for drugs.

To devise a potential new therapy, the investigators engineered a population of neural stem cells to express a potent version of a gene called TRAIL, which codes for a molecule that activates cell - death - inducing receptors found only on the surface of cancer cells.

Receptors are proteins that are usually located on the external surface of the cell membrane; they provide specific recognition sites for messenger substances such as hormones, neurotransmitters and growth factors.

For example, T - cells have a receptor on their surface called PD - 1, which acts as an off switch.

In a major innovation reported last year, Lerner, Zhang and their colleagues developed a basic method for selecting antibodies that not only bind to a given target, such as a cell - surface receptor, but also have a desired biological function — such as activating the receptor on mammalian cells.

The team chose integrin receptors that control a variety of functions on the cell surface as a target for their peptides.

D'Oro, U., Vacchio, M.S., Weissman, A.M. & Ashwell, J.D. Activation of the Lck tyrosine kinase targets cell surface T cell antigen receptors for lysosomal degradation.

Byron B. Goldstein was recognized for his contributions in the field of mathematical immunology and cell biology, specifically in modeling cell signaling cascades, pursuing cutting - edge research in cell activation, cell - signaling, cell surface receptor - ligand interactions, and the generation of allergic responses.

The T4 glycoprotein is a cell - surface receptor for the AIDS virus.

Membrane cholesterol content accounts for developmental differences in surface B cell receptor compartmentalization and signaling.

A conserved motif for the transport of G protein - coupled receptors from the endoplasmic reticulum to the cell surface.

The Cell Surface Signalling Laboratory is interested in identifying new therapeutic targets for both genetic and infectious diseases by using large - scale systematic approaches to discover receptor - ligand interactions that are essential for cellular recognition processes.

The BMP protein acts as an activator for cell — surface receptors, and initiates cellular processes and signaling cascades.

Asialoglycoprotein receptor 1 is a specific cell - surface marker for isolating hepatocytes derived from human pluripotent stem cells.

Distinct Pathways for the Trafficking of Angiotensin II and Adrenergic Receptors from the Endoplasmic Reticulum to the Cell Surface.

Current studies focus mainly on two receptor systems - the mast cell surface receptor, FcεRI, and the receptor for epidermal growth factor that operate in immunological and cell proliferation responses.

Also, genes that code for receptor tyrosine kinases, a family of receptors on the surface of cells, may rearrange to form multiple distinct gene fusion partners, as evidenced in an article by Kulkarni, et al, on a translational study involving a patient who developed a BRAF fusion following treatment with a BRAF inhibitor1.

When testing for HER2, IHC assigns a score of 0 to 3 + to the amount of HER2 receptor protein on the surface of breast cancer cells.

Endocytosis has traditionally been viewed as a mechanism for achieving signal attenuation: activated cell surface receptors are internalised and trafficked through endocytic vesicles to lysosomes, where they are degraded.

Eventually this highly increase uptake for galactose coated NP is due to a specific galactose receptor on the surface of cells [23], [29].

For example, over 60 neuro - transmitters and hormonal receptors have been found on the surface of our disease - fighting immune cells.

This powerful nutrient - partitioning agent significantly improves the insulin sensitivity of active insulin receptors on the cells» surface for greater nutrient uptake and creatine saturation.

For example, fiber is metabolized by our gut flora into short - chain fatty acids, which bind to and activate receptors on the surface of our cells that alter our metabolism, for example, activating receptors on fat cells to increase the expression of the weight - reducing hormone, leptFor example, fiber is metabolized by our gut flora into short - chain fatty acids, which bind to and activate receptors on the surface of our cells that alter our metabolism, for example, activating receptors on fat cells to increase the expression of the weight - reducing hormone, leptfor example, activating receptors on fat cells to increase the expression of the weight - reducing hormone, leptin.

For insulin to work, it must bind to the insulin receptor on the surface of our cells.