Sentences with phrase «cell surface receptors in»

Not exact matches

In my cell biology course, we investigate the biology and chemistry of a cell surface receptor that helps induce good feelings in us when it binds to a chemical compound found in incense; this may help explain why so many different cultures and religions have independently evolved the use of incense in their ceremonies and ritualIn my cell biology course, we investigate the biology and chemistry of a cell surface receptor that helps induce good feelings in us when it binds to a chemical compound found in incense; this may help explain why so many different cultures and religions have independently evolved the use of incense in their ceremonies and ritualin us when it binds to a chemical compound found in incense; this may help explain why so many different cultures and religions have independently evolved the use of incense in their ceremonies and ritualin incense; this may help explain why so many different cultures and religions have independently evolved the use of incense in their ceremonies and ritualin their ceremonies and rituals.

In particular, the PTPRF gene, which is known to suppress intracellular signals that are usually triggered by insulin binding to its receptor on the cell surface, may serve as a biomarker linking insulin resistance with insufficient milk supply.

When similar analysis was performed on the db mice, it was found that the disrupted db gene was responsible for encoding a protein that functions as a leptin receptor: When it binds circulating leptin at the cell surface, it sets in motion a biochemical cascade inside the cell.

Like many drugs, beta blockers target receptors embedded in the surface of cells.

The investigators found that CCL28, which is over-produced in joints affected by rheumatoid arthritis, attracts the surface - lining cells that carry its receptor.

By hindering LMPTP, the drug reawakens insulin receptors on the surface of cells — especially in the liver — which normally absorb excess sugar from the blood when they detect insulin.

The paper, by V. Hegenauer at University of Tübingen in Tübingen, Germany, and colleagues was titled, «Detection of the plant parasite Cuscuta reflexa by a tomato cell surface receptor.»

This drug (vedolizumab) blocks a specific adhesion molecule on the surface of the T - cell and thereby inhibits immune cells from binding themselves to receptors present in the intestine, preventing the T - cells from penetrating the blood vessels in the intestinal tissue.

Investigators linked the ability of regulatory T cells to dampen the Th2 response in part to the ability of LKB1 to restrain expression of the cell surface receptor PD - 1 and possibly other receptors.

The team found that after exposure to chemotherapy, the cells began developing physical markings usually seen in CSCs, including receptors on the cell surface to which specific proteins can bind.

As SNX27 plays an important role in shuttling the AMPA - receptor to the brain cell surface, lower levels of SNX27 means fewer receptors are carried to the surface, which consequently interrupts the signal transmission and impairs memory.

In many very invasive forms of breast cancer, the cells have too much of the receptor HER2 on their surface.

Most cancer vaccines developed to date have been designed to recognize and attack a specific known molecule — such as a cell - surface receptor — that is likely to be found on cancerous cells in any patient with that type of tumor.

A critical discovery in this research was finding that the novel progenitor has a receptor protein on its cell surface called KDR, or vascular endothelial growth factor receptor 2, which until now, was thought to be restricted to endothelial cells that form vessels, the progenitors for endothelial cells and the progenitors blood cells.

Scientists have previously identified a number of mouse smell receptors, cell - surface proteins in the animals» noses that pick up everything from the fragrance of food to the scent of fear (ScienceNOW, 21 August 2008).

In normal cell function messenger chemicals, such as various growth factors and insulin, bind to protein receptors on the cell's surface.

The odorant receptor molecules sit on the surface of sensory nerve cells in our nose.

We would know the basic structure of every last one of its proteins: every enzyme in its metabolism, every signal - bearing hormone coursing through its body, every receptor poised to receive those signals on the surface of its cells.

The MSRs were then coated with lipids that formed a thin supported lipid bilayer (SLB), which resembles the outer membrane of APCs and that the researchers then functionalized with a pair of T cell - stimulating antibodies that remain mobile in the lipid layer and can bind to receptor / co-receptor molecules on the surface of T cells.

Most resistance genes, in wheat and other plants, code for protein receptors located inside cells; the Stb6 gene codes for a receptor protein on the cell's surface.

«Beta blockers may lead to new novel triple negative breast cancer treatments: New research suggests that adrenaline can act on tumor cells via a cell surface receptor called the beta2 - adrenoceptor and that changes in signaling within the cell make it highly invasive.»

In particular, Nguyen and Ehrenstein discovered that adalimumab increases the expression of TNF on the surface of patient monocytes and promotes the association of these TNF molecules with receptor proteins on the surface of regulatory T cells.

In this study, we examined the effectiveness of a vaccination targeting tumors that produced IL - 15 and its cell surface receptor called IL - 15R - alpha -LRB--RRB- and examined their ability to up - regulate (or increase) immune responses to tumor antigens,» Morris says.

This in vivo reconstitution system provides a new approach for examining ligand binding and G protein coupling to cell surface receptors.

Every cell in the body contains receptors — essentially tiny locks — on its surface.

In a new study, biomedical engineers found that by attaching microscopic beads to receptors on the cell's surface, they can produce the technique's cell - stretching, calcium - releasing effects much more safely.

They found that the mutated G1 and G2 variant did so particularly well on what's known as a receptor on the surface of kidney cells, in this case the suPAR activated receptor alphavbeta3 integrin.

In addition, exhausted CD8 T cells start to express inhibitory cell surface receptors that receive and feed inhibitory signals into the cell establishing a negative feedback loop.

Now a team of researchers led by Philip Kim, a professor of computer science and molecular genetics in the University of Toronto's Donnelly Centre for Cellular and Biomolecular Research, has developed a new technology for making mirror - image peptides, which bind and activate receptors on the surface of cells.

Once they are engineered with antibodies that bind to specific receptors on the surface of targeted cells, these nanoparticles also can, in principle, become highly specific to the disease they are designed to treat.

In this case, both teams designed their antibodies to clasp an HIV protein and CD3, a receptor found on the surface of white blood cells.

The mutation in ACVR1 (mACVR1) causes the ACVR1 protein, a cell surface receptor, to be mildly overactive, thereby stimulating the BMP pathway continuously, like a faucet that drips water when it should be turned off.

PDGFRα is a cell surface tyrosine kinase receptor involved in organ development and tumor progression, it is present in multiple cell types such as mesenchymal cells, neurons, astrocytes, megakaryocytes and oligodendrocyte progenitor.

A similar mutation, detected by S1 nuclease mapping of LDL receptor messenger RNA, occurred in a patient with familial hypercholesterolemia whose receptor also fails to be transported to the cell surface.

Cell - surface receptors are proteins embedded in the cell membrCell - surface receptors are proteins embedded in the cell membrcell membrane.

New findings published in the journal Nature Chemical Biology by UNC School of Medicine scientists show that MRGRPX2, a receptor protein on the surface of mast cells, can trigger the immune system response that leads to itching associated with some opioids.

«We were able to identify the receptor BAI3, a protein at the surface of myoblasts, as one of the crucial missing links in the fusion of muscle cells,» adds Dr. Côté.

In human medicine EGFR is frequently used as the target of cancer immunotherapy because many cancer cells bear this receptor on their surface.

Deletion in cysteine - rich region of LDL receptor impedes transport to cell surface in WHHL rabbit

The ccr5 receptor, a protein found on the surface of cd4 T - cell lymphocytes in the immune system (try saying that quickly), may hold the key to ending the aids pandemic (see «The End of AIDS»).

Now, Skehel, along with colleagues at Harvard, Yale, and Emory University in Atlanta, Georgia, has used that sequence to build the virus's hemagglutinin (HA)-- a protein that latches onto receptors on the host cell surface — and determine its structure.

A team of researchers from the Pasteur Institute in Paris has discovered a second receptor on the surface of cells that helps HIV to enter and infect them.

In 2006, researchers discovered the genetic defect behind FOP: A mutated version of the gene ACVR1, which in patients produces an overactive form of a cell surface protein called a transmembrane receptoIn 2006, researchers discovered the genetic defect behind FOP: A mutated version of the gene ACVR1, which in patients produces an overactive form of a cell surface protein called a transmembrane receptoin patients produces an overactive form of a cell surface protein called a transmembrane receptor.

In earlier research, Barbolina discovered that a fractalkine receptor — a protein found on the cell surface — is expressed in the majority of ovarian cancer caseIn earlier research, Barbolina discovered that a fractalkine receptor — a protein found on the cell surface — is expressed in the majority of ovarian cancer casein the majority of ovarian cancer cases.

Dr. Shiloh and his team currently are working to discover the human cell - surface receptors for Mtb that are involved in the bacteria's M - cell translocation, as well as to determine the exact machinery used by the cell to move the bacteria from the surface to the bottom of the cell.

«It took us around four years to discover that phthalocyanine, which is a blue paint used on the surface of the Japanese bullet trains and road signs, could bind competitively to the HasA protein,» adds Ms. Chikako Shirataki, a PhD student in her final year, «crystal structures of metal protein complexes helped us to show that the phthalocyanine - bound HasA protein blocks the receptors on the cell surface of the bacterium and thus, inhibits the uptake of heme.»

In the new work, the researchers added serum from Finnish narcolepsy patients who had received Pandemrix to cells that were engineered to display human hypo cretin receptor 2 on their surface.

Farzan and his team discovered in their work with monkeys that HIV can't invade cells if those cells» two surface receptors are blocked — like a keyhole jammed with gum.

The other end, known as the constant region, binds to receptors on the surface of cells that can direct the immune system to respond in a variety of ways, all in the hopes of eliminating the target on the variable end of the antibody.

The outer surface of many of our cells, including those in the airways, has a protein called the H1 receptor.