Sentences with phrase «cell surface receptors on»

This communication involves the release of chemicals from neurons that stimulate cell surface receptors on other neurons.

Recognition of IL - 23 by its cell surface receptor on cells primarily activates JAK2 and the downstream transcription factor STAT3 [44].

Not exact matches

At the end of September, the European Commission approved a marketing application for Lutathera, a radioactive molecule that targets specific receptors found on the surface of neuroendocrine tumor cells.

The human body has about 1,000 kinds of such receptors, structures on the surface of cells, which let the body respond to a wide variety of chemical signals, like adrenaline.

In particular, the PTPRF gene, which is known to suppress intracellular signals that are usually triggered by insulin binding to its receptor on the cell surface, may serve as a biomarker linking insulin resistance with insufficient milk supply.

When similar analysis was performed on the db mice, it was found that the disrupted db gene was responsible for encoding a protein that functions as a leptin receptor: When it binds circulating leptin at the cell surface, it sets in motion a biochemical cascade inside the cell.

The antibody binds to a protein on the surface of T cells called the PD - 1 receptor.

By hindering LMPTP, the drug reawakens insulin receptors on the surface of cells — especially in the liver — which normally absorb excess sugar from the blood when they detect insulin.

The immune system depends on molecules called T cell receptors on the surface of T cells to recognize and respond to foreign antigens from virus - infected cells, tumors and other threats.

«Myeloid - derived suppressor cells (MDSCs) produce reactive nitrogen radicals that alter the receptors on the surface of the tumour to hide it from cytotoxic lymphocytes that kill tumour cells.

This drug (vedolizumab) blocks a specific adhesion molecule on the surface of the T - cell and thereby inhibits immune cells from binding themselves to receptors present in the intestine, preventing the T - cells from penetrating the blood vessels in the intestinal tissue.

The team found that after exposure to chemotherapy, the cells began developing physical markings usually seen in CSCs, including receptors on the cell surface to which specific proteins can bind.

Not to science, though: the taste has recently been traced to a single receptor on the surface of cells on your tongue.

The scientists observed that transmission of chemical signals between the nerve cells are facilitated by AMPA - receptors and the activity occurs on the brain cell surface.

Called TSH for short, this hormone attaches to a receptor on the thyroid cell surface, triggering a series of signals that provoke the gland to pump out thyroid hormones.

One key gene encodes the making of a receptor called TREM2, a docking site for molecules on the surface of microglia and other innate immune cells.

In many very invasive forms of breast cancer, the cells have too much of the receptor HER2 on their surface.

Previous studies have found that brown fat can be coaxed into action by activating the β3 - adrenergic receptor, which is expressed on the surfaces of brown and white fat cells, as well as on cells of the urinary bladder and other tissues.

What they discovered was that an inflammatory factor known as TGF - beta (transforming growth factor - beta) can give cancer cells properties of immune cells by supplying the surface of the cancer cell with a receptor that normally only exists on the white blood cells that travel through the lymphatic system.

Work is now continuing to study what transmitter substance and what receptor on the surface of the cell are responsible for the newly discovered timing mechanism.

First, it latches onto a receptor on the cell surface.

The drug blocks CTLA - 4, a protein receptor on the surface of T - cells that serves as a molecular stop sign, preventing the immune system from going into overdrive.

Various receptors which can either activate or inhibit the cell have been identified on cell surface.

Endocannabinoids act on a group of cell - surface molecules called cannabinoid receptors that help to regulate appetite, mood and memory.

Previous research had shown that nicotine seems to have conflicting effects on different types of nicotinic acetylcholine receptors, proteins on the surface of brain cells that respond to nicotine and the naturally occurring neurotransmitter acetylcholine.

Most cancer vaccines developed to date have been designed to recognize and attack a specific known molecule — such as a cell - surface receptor — that is likely to be found on cancerous cells in any patient with that type of tumor.

A critical discovery in this research was finding that the novel progenitor has a receptor protein on its cell surface called KDR, or vascular endothelial growth factor receptor 2, which until now, was thought to be restricted to endothelial cells that form vessels, the progenitors for endothelial cells and the progenitors blood cells.

Atypical receptors appeared on the surfaces of neurons and allowed calcium ions inside the cells.

Both are loaded with opioid receptors — proteins that sit on the surface of cells and grab onto opioids.

These proteins latch onto their receptor on the surfaces of neighboring cells and kick - start the production of hundreds of other antiviral proteins.

By latching onto receptors on the surface of T lymphocytes, gp120 allows the virus to enter the cells and reproduce.

2) Protein binds to CD3 receptor on helper T cell, activating it so the helper T cell starts making HIV and displaying pieces of virus (red) on its surface.

The good news about the complex interconnectivity is that the scientists also were able to find a potential future point of intervention: When they gave a drug that increased AMPA receptor expression on the cell surface, the spines assumed a more healthy, mature state.

The engineered protein has two ends: one activates T cells by binding to a surface molecule called the CD3 receptor, and the other — based on an antibody called VRC07 — powerfully binds to more than 90 percent of HIV strains.

In normal cell function messenger chemicals, such as various growth factors and insulin, bind to protein receptors on the cell's surface.

The odorant receptor molecules sit on the surface of sensory nerve cells in our nose.

The key discovery made by the CSHL team is that FER is able to activate a receptor on the surface of ovarian cells «from below,» as it were — by interacting with a portion of the receptor that penetrates the cell membrane and plunges into the cytoplasm.

We would know the basic structure of every last one of its proteins: every enzyme in its metabolism, every signal - bearing hormone coursing through its body, every receptor poised to receive those signals on the surface of its cells.

pAPCs express toll - like receptors on their surfaces that recognize and trap molecular patterns called antigens on bacteria, food and our own cells.

They have also isolated specific receptors on the surfaces of cancer cells that green tea compounds may interact with.

The researchers found that POSTN acted through a specific integrin receptor that was present on the surface of many BLBC cells.

The MSRs were then coated with lipids that formed a thin supported lipid bilayer (SLB), which resembles the outer membrane of APCs and that the researchers then functionalized with a pair of T cell - stimulating antibodies that remain mobile in the lipid layer and can bind to receptor / co-receptor molecules on the surface of T cells.

MERS CoV (CoV stands for coronavirus) has on its surface an array of spike - shaped proteins that bind to host cells — specifically to receptor proteins called DPP4 on the surface of cells that line human airways.

Most resistance genes, in wheat and other plants, code for protein receptors located inside cells; the Stb6 gene codes for a receptor protein on the cell's surface.

«Beta blockers may lead to new novel triple negative breast cancer treatments: New research suggests that adrenaline can act on tumor cells via a cell surface receptor called the beta2 - adrenoceptor and that changes in signaling within the cell make it highly invasive.»

In particular, Nguyen and Ehrenstein discovered that adalimumab increases the expression of TNF on the surface of patient monocytes and promotes the association of these TNF molecules with receptor proteins on the surface of regulatory T cells.

A normal cell has chemical receptors on its surface that link up with specific molecules generated by the body and control the timing of such functions as eating and sleeping.

Hemagglutinin binds to glycan receptors found on the surface of respiratory cells, and the strength of that binding determines how effectively the virus can infect those cells.

Triple - negative breast cancers are those whose cells lack estrogen receptors and progesterone receptors, and do not have an excess of the HER2 protein on their surfaces.

Think of brain cells as rooms with locks called receptors on their surfaces and a hypocretin as a key that is also a stimulant.